Background: Depression is one of the common psychiatric disorders which are more common in women in the reproductive ages. So this study is to investigate the effect of Depo-Provera on depression.

Materials and Methods: This cross-sectional study was performed on 70 women who had chosen Depo-Provera as contraception. Beck test was done at arrival and repeated 3 months later, and the scores obtained were compared by paired t test.

Results: The participants BDI scores at baseline were equal to 7.89±3.85 while 3 months after treatment with the scores were equal to 7.09±3.63 which were significantly decreased.

Conclusion: Since Depo-Provera reduces depressive symptoms in women who take it and does not increase these symptoms in women with a history of depression, it seems that Depo-Provera is an appropriate choice as contraception.