Volume 13, Issue 4 (1-2011)
J Arak Uni Med Sci 2011, 13(4): 8-14 |
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amini M, hosseini S A, jand Y, zandbaf T, eshrati B, alizadeh S, et al . The diagnostic value of blood antioxidants in the diagnosis of acute appendicitis. J Arak Uni Med Sci 2011; 13 (4) :8-14
URL: http://jams.arakmu.ac.ir/article-1-688-en.html
URL: http://jams.arakmu.ac.ir/article-1-688-en.html
Mahmood Amini 
1, Seid alireza Hosseini , Yahya Jand , Tooraj Zandbaf , Babak Eshrati , Shabanali Alizadeh , Ghasem Mosayebi , Ali Ghazavi , Ali Cyrus
1, Seid alireza Hosseini , Yahya Jand , Tooraj Zandbaf , Babak Eshrati , Shabanali Alizadeh , Ghasem Mosayebi , Ali Ghazavi , Ali Cyrus
1- , yahya_jand@yahoo.com
Abstract: (17221 Views)
Background: Nowadays, the use of inflammatory biomarkers in the diagnosis of appendicitis is on the rise. On the other hand, the role of oxygen free radicals in various inflammatory states has been verified. Noticing the high prevalence of negative appendectomy (9.3-22.2%), the aim of this study was to investigate the level of blood total antioxidant capacity (TAC) as a biomarker for early diagnosis of acute appendicitis. Materials and Methods: In this prospective analytical trial, over a one-year period, 407 patients, with preoperative diagnosis of acute appendicitis who had undergone operation, were studied. After measuring the TAC level, data were analyzed through the analytic ROC curve and parametric mean comparison tests. Results: Of all the patients, 298 were identified with appendicitis. TAC levels in adult female and male groups were respectively 663.9±164.75 and 752.58±167.37 µm/L which revealed a significant difference (p<0.0001). Also, in children, the mean of TAC level in perforated appendicitis sub-group was significantly greater than those in gangrenous and suppurative groups. Conclusion: TAC level can be used as a predictive factor for the diagnosis of perforated appendicitis in children however, it cannot be used as a biomarker for the diagnosis of appendicitis. Because of the significant difference existing between the level of TAC in male and female patients, further studies are suggested to investigate the level of inflammatory biomarkers with respect to menstrual cycle in women.
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