Volume 7, Issue 1 (Spring 2004)
J Arak Uni Med Sci 2004, 7(1): 47-53 |
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Honarkar Z, Alaviyan M, Samiei S, Saeedfar K, Baladast M, Aghazadeh R et al . Serological and Molecular Evidence of Hepatitis B in Patients With Chronic Hepatitis C. J Arak Uni Med Sci 2004; 7 (1) :47-53
URL: http://jams.arakmu.ac.ir/article-1-6780-en.html
URL: http://jams.arakmu.ac.ir/article-1-6780-en.html
Zahra Honarkar 
, Moayed Alaviyan , Shahram Samiei , Keyvan Saeedfar , Mahnaz Baladast , Rahim Aghazadeh , Mohammad Reza Zali
, Moayed Alaviyan , Shahram Samiei , Keyvan Saeedfar , Mahnaz Baladast , Rahim Aghazadeh , Mohammad Reza Zali
Abstract: (1368 Views)
Introduction: Hidden hepatitis B is a condition in which the surface antigen of hepatitis B in the patient's serum is negative but the DNA of the hepatitis B virus is detected in the serum or liver tissue. In this study, the prevalence of latent hepatitis B in chronic hepatitis C patients and their biochemical and histological changes were investigated.
method: In this descriptive study, target sampling was performed so that 27 chronic hepatitis C patients whose HBsAg was negative and during 2001 and 2002 to two hepatitis centers of Tehran and Research Center for Gastrointestinal and Liver Diseases of Shahid University of Medical Sciences Beheshti came in and underwent liver sampling. On the hepatic paraffinic block of these patients, polymerase chain reaction tests were performed for the presence of HBVDNA, as well as immunohistochemical tests for the presence and detection of HBsAg and central hepatitis B antigen.
Results: Of the 27 PCR samples examined, patients reported positive HBVDNA in 5 cases (19%). In all of these patients, IHC tests were reported to be negative for HBsAg and HBcAg. Histological changes of cirrhosis and irreversible cirrhosis symptoms were seen only in the HBVDNA group.
Conclusion: The prevalence of latent hepatitis B is relatively high in patients with hepatitis C. In these patients, latent hepatitis B can exacerbate liver damage and accelerate the progression of cirrhosis.
method: In this descriptive study, target sampling was performed so that 27 chronic hepatitis C patients whose HBsAg was negative and during 2001 and 2002 to two hepatitis centers of Tehran and Research Center for Gastrointestinal and Liver Diseases of Shahid University of Medical Sciences Beheshti came in and underwent liver sampling. On the hepatic paraffinic block of these patients, polymerase chain reaction tests were performed for the presence of HBVDNA, as well as immunohistochemical tests for the presence and detection of HBsAg and central hepatitis B antigen.
Results: Of the 27 PCR samples examined, patients reported positive HBVDNA in 5 cases (19%). In all of these patients, IHC tests were reported to be negative for HBsAg and HBcAg. Histological changes of cirrhosis and irreversible cirrhosis symptoms were seen only in the HBVDNA group.
Conclusion: The prevalence of latent hepatitis B is relatively high in patients with hepatitis C. In these patients, latent hepatitis B can exacerbate liver damage and accelerate the progression of cirrhosis.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2021/01/27 | Accepted: 2004/03/29
Received: 2021/01/27 | Accepted: 2004/03/29
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