Volume 20, Issue 7 (10-2017)
J Arak Uni Med Sci 2017, 20(7): 77-88 |
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Anbara H, Morovvati H, Adib Moradi M, Shahrooz R. Histological and Biochemical Analyses of the Effects of Royal Jelly and Vitamin C against Phenylhydrazine-Induced Cardiotoxicity in Mice. J Arak Uni Med Sci 2017; 20 (7) :77-88
URL: http://jams.arakmu.ac.ir/article-1-5170-en.html
URL: http://jams.arakmu.ac.ir/article-1-5170-en.html
1- Department of Comparative Histology& Embryology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran , hojat.anbara@ut.ac.ir
2- Department of Comparative Histology & Embryology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3- Department of Comparative Histology & Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
2- Department of Comparative Histology & Embryology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3- Department of Comparative Histology & Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Abstract: (4010 Views)
Abstract
Background: Phenylhydrazine (PHZ) as a strong oxidant agent causes variety of toxic effects including alterations in the biochemical and cardiac tissue. The aim of the present study was to investigate the effects of royal jelly (RJ) and vitamin C (vit C) against PHZ-induced cardiotoxicity in mice.
Materials and Methods: Adult male mice were randomly assigned to eight groups of eight mice each. PHZ was administered to four groups of mice at a dose of 60 mg/kg per 48 hours intraperitoneally for 35 days. Three of these groups received vit C (250 mg/kg per day) intraperitoneally, RJ (100 mg/kg per day) orally and vit C+RJ with same doses four hours before PHZ administration, respectively. A vehicle-treated control group and vit C, RJ and vit C+RJ control groups were also included.
Results: RJ and vit C significantly decreased (p< 0.05) the serum level of malondialdehyde and creatine kinase (CK-BM) that had been increased by PHZ. Also, RJ and vit C increased the total antioxidant capacity and supraxoid dismutase serum that had been decreased by induced PHZ. Moreover, RJ and vit C could improve the tissue damages induced by PHZ such as diffused edema, hemorrhage, congestion, hyaline exudates, necrosis and also fibrosis tissue in heart tissue.
Conclusion: It seems that Vit C and RJ can minimize PHZ-induced cardiotoxicity in mouse through oxidative reactions inhibition.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2017/06/9 | Accepted: 2017/09/13
Received: 2017/06/9 | Accepted: 2017/09/13
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