BACKGROUND: Acne vulgaris is chronic  inflamatory disease  of the pilosebaceous unit.Patients  experience  psychological  burdens like depression ,anxiety , and low self-esteem. Isotretinoin  is used in the treatment of  severe ,recalcitrant acne ;however,treatment  commonly results in associated   with  a  number  of  adverse effects that treatment stopped  consequent  this side effects. The aim of this study is to evaluate  the effect of oral  omega 3 on  side-effects of  isotretinoin .

METHODS:One  hundred eighteen  patients with sever acne vulgaris  were  randomized to two groups. Control group recived  isotretinoin (0.5 mg∕kg) alone and case  group received  isotretinoin (0.5 mg∕kg)  combined  with omega 3 (2 capsuls) daily.the treatment duration was 16 weeks.Mucocutaneous  side-effects  were assessed(4,8,12,16th wk).

RESULTS:Lip  dryness (4,8,12th wk)  and  dryness of nose, skin ,eye  in the 4 th week in the patients treated with isotretinoin and omega3 was lesser than in the patients treated with isotretinoin  (P value < 0.001).

CONCLUSION:Omega 3 decreased  the  mucocutaneous side effects in the patients  with acne   vulgaris   who received  isotretinoin.