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Background: Studies in different species indicate that a variety of different inhibitors may influence myometrium during pregnancy and withdrawal of one or more of them leads to the onset of labor pain. Hence, this study was done to investigate the association between parathyroid hormone-related peptide1-34 (PTH-rp1-34) and labor pain. Materials and Methods: This study was a case-control one. Plasma PTH-rp1-34, PTH, total calcium, phosphorous, magnesium, and alkaline phosphatase concentrations were quantified for 152 normal pregnant women at term (76 women at the onset of labor pain, as the case group and 76 women without labor pain, as the control group). The subjects had no pregnancy related complications. Results: The mean of plasma PTHrp concentrations in the group with labor pain (12.36±0.60 ng/ml) did not differ from that in the group without labor pain (13.57±0.63 ng/ml). The means of plasma PTHrp concentration amounts in the group with labor pain and the group without labor pain were 28.92±1.66 pg/ml and 31.88±1.64 pg/ml, respectively and there was no significant difference between the two groups. There were no significant difference in plasma calcium, phosphorus, magnesium, and alkaline phosphatase concentrations in the two groups too. Conclusion: In this study, the endocrinal role of PTHrp and the onset of labor pain was not confirmed.

Keywords: Parturition, PTHrp, uterine contraction

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