Background: It is expected that affected people with diabetes will increase to 439 million in 2030, 15% of them are affected with chronic leg ulcer disease. Increasing number of researches implicate the positive influence of pentoxifylline (PTX) on the skin wound healing. Pentoxifylline is a xantin derivative that modifies or inhibits inflammatory factors, reduces blood viscosity, improves peripheral blood currency and increases oxygenation of tissues the In this study the effect of Pentoxifylline (PTX) on skin biomechanical indices in acute phase of skin wound healing in diabetic rat is in considerable interest.

Materials and Methods: It is an experimental- interventional study in which fourteen adult male wistar rats were divided into experimental group (n=7), receiving pentoxifyllineintraperitoneally and control group (n=7) receiving distilled water (DW). Diabeteswas induced by intraperitoneal administration of streptozotocin in both groups then full thickness incisional wound (20mm length) in identical pattern was made on the dorsum of rats. After 15 days a band of skin (4×60mm) containing wound was extracted and used to evaluate skin biomechanical indexes (work up to maximum force-Nm and Tensile strength= Rm-N/mm2). Results were analysed by SPSS software version 19 and K-S, Levens Test and Student SampleT-Test were used.

Results: Pentoxifylline administration improved skin biomechanical indices after 15 days after skin incisional wound. Differences between experimental and control’s indices were significant (p<0.05).

Conclusion: Pentoxifylline accelerated wound healing and improved tensile strength of skin in diabetic rats of experimental group.