fa بررسی ارتباط سطح سرمی ویتامینD با رخداد و شدت پنومونی در بیماران با پنومونی اکتسابی از جامعه:یک مطالعه مورد شاهدی عفونی Infection پژوهشي اصیل Original Atricle <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span style="font-family:"B Nazanin""></span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">چکیده ی مقاله:</span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black">مقدمه:</span></span></span></span></b><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black"> پنومونی </span></span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">CAP</span></span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black"> یکی از شایع ترین بیماری های عفونی می باشد که منجر به بستری بیماران می شود، هم چنین تاثیرات کمبود ویتامین </span></span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">D</span></span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black"> بر عملکرد سیستم ایمنی بدن و ارتباط آن با بیماری های عفونی از جمله پنومونی </span></span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">CAP</span></span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black"> در سال های اخیر مورد توجه بسیار قرار گرفته است. در نتیجه بر آن شدیم تا ارتباط سطح سرمی ویتامین </span></span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">D</span></span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black"> را با رخداد و شدت پنومونی </span></span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">CAP</span></span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black"> در این مطالعه بررسی کنیم.</span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black">روش مطالعه: </span></span></span></span></b><b><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black">در این مطالعه مورد-شاهدی 75 نفر از بیماران مبتلا به پنومونی </span></span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">CAP</span></span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black"> و 75 افراد سالم مورد بررسی قرار گرفتند و سطح سرمی ویتامین </span></span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">D</span></span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black"> در این دو گروه سنجیده شد و مورد مقایسه قرار گرفت.</span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black">یافته ها:</span></span></span></span></b><b> </b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">مطالعه حاضر نشان می&shy;دهد به ازای هر یک واحد افزایش در سطح سرمی ویتامین </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">D</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">، نیاز به بستری در </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">ICU</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> طبق معیار </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">IDSA</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> هفت درصد کاهش و طبق معیار </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">CURB65</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> نیاز به بستری در بخش و </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">ICU</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> پانزده درصد کاهش می یابد.</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">هم چنین کمبود ویتامین </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">D</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> در مقابل کافی بودن آن شانس رخداد پنومونی اکتسابی</span></span></span> <span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">از جامعه را 08/3 برابر می&shy;کند. و به ازای هر یک واحد افزایش در ویتامین </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">D</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">، شانش رخداد پنومونی اکتسابی از جامعه 4 درصد کاهش می یابد.</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black">نتیجه گیری: </span></span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black">در مجموع بر اساس نتایج حاصل از این مطالعه چنین استنباط می شود که کمبود ویتامین </span></span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">D</span></span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black"> با افزایش رخداد و هم چنین شدت بیشتر پنومونی </span></span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">CAP</span></span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"><span style="color:black"> همراهی دارد.</span></span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Abstract:</span></span></span></b></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Background</span></span></span></b></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">CAP ( community acquired pneumonia ) is one of the most common infectious diseases that leads to hospitalization of patients. Also, the effects of vitamin D deficiency on the functioning of the immune system and its association with infectious diseases such as CAP have received much attention in recent years. Therefore, we decided to investigate the relationship between serum vitamin D levels and the incidence and severity of CAP pneumonia in this study.</span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Methods</span></span></span></b></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">In this case-control study, 75 patients with CAP &nbsp;and 75 healthy individuals were evaluated and serum levels of vitamin D in these two groups were measured and compared.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Results</span></span></span></b></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">The present study shows that for each unit increase in serum vitamin D level, the need for hospitalization in the ICU according to the IDSA criterion is reduced by seven percent and according to the CURB65 criterion, the need for hospitalization in the ward and ICU is reduced by fifteen percent. Vitamin D deficiency also increases the chance of developing community-acquired pneumonia by 3.08 times. And for every unit increase in vitamin D, the chance of developing community-acquired pneumonia decreases by 4 percent. And in people with vitamin D deficiency, the chance of being admitted to the ICU according to IDSA is 2.05 times and according to CURB65 is 2.84 times.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Conclusions</span></span></span></b></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Overall, based on the results of this study, it is concluded that vitamin D deficiency is associated with an increased incidence as well as a greater severity of community acquired pneumonia.</span></span></span></span></span></span><br> &nbsp; پنومونی CAP - ویتامین D - معیار IDSA-ATS - معیار CURB65 CAP ( community acquired pneumonia) , Vitamin D , IDSA-ATS criterion , CURB65 criterion 0 0 http://jams.arakmu.ac.ir/browse.php?a_code=A-10-7512-1&slc_lang=fa&sid=1 behrooz ghanbari بهروز قنبری g.behrooz@gmail.com 4600319475328460087198 4600319475328460087198 Yes mojtaba hedayat taghavi مجتبی هدایت تقوی daneshjo.b@gmail.com 4600319475328460087199 4600319475328460087199 No behamin astani بهامین آستانی tokito.ir@gmail.com 4600319475328460087200 4600319475328460087200 No mahmoud bakhtiari محمود بختیاری tokito.niavaran@gmail.com 4600319475328460087201 4600319475328460087201 No mohsen yadegari محسن یادگاری tokitofood@gmail.com 4600319475328460087202 4600319475328460087202 No yazdan shafikhani یزدان شفی خانی yazdan.shafikhani@gmail.com 4600319475328460087203 4600319475328460087203 No