fa مقایسه اثر بخشی مصرف روغن کرچک خوراکی و میزوپروستول واژینال با میزوپروستول واژینال به تنهایی در درمان سقط فراموش شده اطفال Pediatrics پژوهشي اصیل Original Atricle <p class="MsoNormal" dir="rtl" style="text-justify: kashida text-align: justify text-kashida: 0% margin: 0cm 28.9pt 0pt"><font size="3"><font color="#000000"><b><span lang="FA" style="font-family: 'B Mitra' letter-spacing: -0.3pt">زمینه و هدف:</span></b><span lang="FA" style="font-family: 'B Mitra' mso-no-proof: yes"> سقط فراموش شده به معنای باقی ماندن محصولات حاملگی مرده با سن کمتر از 20 هفته در رحم به مدت چندین هفته می‌باشد. این پژوهش به منظور بررسی اثر بخشی روغن کرچک بر آمادگی سرویکس در درمان سقط طراحی شد.</span></font></font></p> <p class="MsoNormal" dir="rtl" style="text-justify: kashida text-align: justify text-kashida: 0% margin: 0cm 28.9pt 0pt"><font size="3"><font color="#000000"><b><span lang="FA" style="font-family: 'B Mitra' letter-spacing: -0.3pt">مواد و روش‌ها:</span></b><span lang="FA" style="font-family: 'B Mitra' mso-no-proof: yes"> این کارآزمایی بالینی سه سوکور بر روی 72 زن باردار با سقط فراموش شده صورت گرفت که بر اساس زوج یا فرد بودن شماره پرونده به دو گروه 36 نفری تقسیم شدند. گروه مورد 800 میکروگرم میزوپروستول واژینال و 60 میلی</span><span lang="FA" style="font-family: 'B Mitra'">‌<span style="mso-no-proof: yes">لیتر روغن کرچک خوراکی توام با آب میوه و گروه شاهد 800 میکروگرم میزوپروستول واژینال و 60 میلی</span>‌<span style="mso-no-proof: yes">لیتر دارونما توام با آب میوه دریافت نمودند. در هر دو گروه ، در صورت نیاز، 3 دوز شیاف واژینال به میزان 800 میکروگرم و با فاصله حداقل 24 ساعت تکرار شد. پس از دفع محصولات بارداری، سونوگرافی صورت گرفت و در صورت لزوم کورتاژ انجام شد‌. </span></span></font></font></p> <p class="MsoNormal" dir="rtl" style="text-justify: kashida text-align: justify text-kashida: 0% margin: 0cm 28.9pt 0pt"><font color="#000000"><font size="3"><b><span lang="FA" style="font-family: 'B Mitra' letter-spacing: -0.3pt">یافته‌ها:</span></b><span lang="FA" style="font-family: 'B Mitra' mso-no-proof: yes"> در طول مداخله، مدت زمان باز شدن دهانه رحم در گروه مداخله نسبت به گروه شاهد کوتاه تر بود و اختلاف آماری معنی‌دار بود(032/0</span></font><span lang="FA" style="font-family: 'B Mitra' font-size: 11pt mso-no-proof: yes">=</span><font face="Times New Roman"><span dir="ltr" style="font-size: 11pt mso-bidi-font-family: 'B Mitra' mso-no-proof: yes">p</span></font><span lang="FA" style="font-family: 'B Mitra' mso-no-proof: yes"><font size="3">). هم</font></span><span lang="FA" style="font-family: 'B Mitra'"><font size="3">‌<span style="mso-no-proof: yes">چنین، گروه شاهد به تعداد دفعات تجویز میزوپروستول بیشتری نسبت به گروه مداخله نیاز داشتند و اختلاف آماری معنی</span>‌<span style="mso-no-proof: yes">دار بود(037/0</span></font></span><span lang="FA" style="font-family: 'B Mitra' font-size: 11pt mso-no-proof: yes">=</span><font face="Times New Roman"><span dir="ltr" style="font-size: 11pt mso-bidi-font-family: 'B Mitra' mso-no-proof: yes">p</span></font><span lang="FA" style="font-family: 'B Mitra' mso-no-proof: yes"><font size="3">). </font></span></font></p> <p class="MsoNormal" dir="rtl" style="text-justify: kashida text-align: justify text-kashida: 0% margin: 0cm 28.9pt 0pt"><font size="3"><font color="#000000"><b><span lang="FA" style="font-family: 'B Mitra' letter-spacing: -0.3pt">نتیجه گیری:</span></b><span lang="FA" style="font-family: 'B Mitra' mso-no-proof: yes"> به نظر می‌رسد که روغن کرچک بتواند بر آمادگی سرویکس در درمان سقط مؤثر باشد.</span></font></font></p> <p></p> <p class="MsoNormal" style="text-justify: kashida text-align: justify text-kashida: 0% text-indent: 36pt margin: 0cm 0cm 0pt unicode-bidi: embed direction: ltr"><font face="Times New Roman"><font color="#000000"><b><i><span style="font-size: 11pt mso-bidi-font-family: 'B Zar'">Background:</span></i></b><span style="font-size: 11pt mso-bidi-font-family: 'B Zar'"> </span><span class="hps"><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN">Missed abortion</span></span><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN"> <span class="hps">refers to</span> <span class="hps">pregnancy products</span> <span class="hps">remain</span> <span class="hps">dead</span> <span class="hps">with</span> <span class="hps">age</span> <span class="hps">less</span> <span class="hps">than 20</span> <span class="hps">weeks</span> <span class="hps">in the womb</span> <span class="hps">for</span> <span class="hps">several</span> <span class="hps">weeks. This</span> <span class="hps">study was designed to</span> <span class="hps">evaluate the efficacy of</span> <span class="hps">castor oil on</span> <span class="hps">cervical ripening in</span> <span class="hps">the</span> <span class="hps">treatment</span> <span class="hps">of abortion</span>.<span class="hps"></span></span></font></font></p> <p class="MsoNormal" style="text-justify: kashida text-align: justify text-kashida: 0% text-indent: 36pt margin: 0cm 0cm 0pt unicode-bidi: embed direction: ltr"><font color="#000000"><font face="Times New Roman"><b><span style="font-size: 11pt mso-bidi-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman'"><em>Materials and Methods:</em></span></b><span class="hps"><span style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN"> <span lang="EN">This</span></span></span><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN"> <span class="hps">triple blind clinical trial was done</span> <span class="hps">on</span> <span class="hps">72</span> <span class="hps">women</span> <span class="hps">with</span> <span class="hps">missed abortion</span> who <span class="hps">were divided</span> <span class="hps">into two groups of</span> <span class="hps">36</span> <span class="hps">patients based on odd or even numberd of cases. The case groups received 800 </span></span></font><span class="hps"><span lang="EN" style="font-family: Symbol font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN mso-ascii-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol">m</span></span></span><font face="Times New Roman"><span class="hps"><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN">g vaginal misoprostol and 60 ml castor oil mixed with fruit juice and control </span></span><span class="hps"><span style="font-size: 11pt mso-bidi-font-family: 'B Zar'">groups received</span></span><span class="hps"><span style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN"> <span lang="EN">800 </span></span></span></font><span class="hps"><span lang="EN" style="font-family: Symbol font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN mso-ascii-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol">m</span></span></span><font face="Times New Roman"><span class="hps"><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN">g vaginal misoprostol and 60 ml placebo with fruit juice, respectively. In both groups,</span></span><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN"> <span class="hps">if needed</span>, 3 doses of <span class="hps">vaginal suppository</span> <span class="hps">800</span> </span></font><span class="hps"><span lang="EN" style="font-family: Symbol font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN mso-ascii-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol">m</span></span></span><font face="Times New Roman"><span class="hps"><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN">g</span></span><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN"> <span class="hps">were repeated</span> <span class="hps">with</span> <span class="hps">at least</span> <span class="hps">24</span> <span class="hps">hours</span>.<span class="hps"> After the</span> <span class="hps">disposal</span> <span class="hps">of pregnancy</span> <span class="hps">products, sonography</span> <span class="hps">and</span> <span class="hps">curettage</span> <span class="hps">were performed</span> <span class="hps">if necessary</span>.</span><span class="hps"><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar'"> </span></span><span class="hps"><span style="font-size: 11pt mso-bidi-font-family: 'B Zar'"></span></span></font></font></p> <p class="MsoNormal" style="text-justify: kashida text-align: justify text-kashida: 0% text-indent: 36pt margin: 0cm 0cm 0pt unicode-bidi: embed direction: ltr"><font color="#000000"><font face="Times New Roman"><b><span style="font-size: 11pt mso-bidi-font-family: 'B Zar'"><em>Results:</em></span></b><span class="hps"><span style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN"> <span lang="EN">During the</span></span></span><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN"> <span class="hps">intervening</span> <span class="hps">period</span>, <span class="hps">the time of the opening of the cervix in the intervention group was shorter than control group and there was a statistically significant difference (p=0.032). Also, the control group required a higher</span> <span class="hps">frequency of</span> <span class="hps">administration of</span> <span class="hps">misoprostol than intervention group</span> <span class="hps">and the</span> <span class="hps">difference</span> <span class="hps">was statistically significant</span> <span class="hps">(p = 0.037)</span></span><span class="hps"><span style="font-size: 11pt mso-bidi-font-family: 'B Zar'">.</span></span></font></font></p> <p class="MsoNormal" style="text-justify: kashida text-align: justify text-kashida: 0% text-indent: 36pt margin: 0cm 0cm 0pt unicode-bidi: embed direction: ltr"><font color="#000000"><font face="Times New Roman"><b><i><span style="font-size: 11pt mso-bidi-font-family: 'B Zar'">Conclusion:</span></i></b><span class="hps"><span style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN"> <span lang="EN">It seems that the</span></span></span><span lang="EN" style="font-size: 11pt mso-bidi-font-family: 'B Zar' mso-ansi-language: EN"> <span class="hps">castor oil</span> <span class="hps">can</span> <span class="hps">be effective</span> <span class="hps">on cervical ripening for treatment of</span> <span class="hps">abortion</span>.<span class="hps"></span></span></font></font></p> <p></p> روغن کرچک, سقط فراموش شده, میزوپروستول Castor oil, Missed abortion, Misoprostol 30 38 http://jams.arakmu.ac.ir/browse.php?a_code=A-10-3582-1&slc_lang=fa&sid=1 Mehri Jamilian مهری جمیلیان Mjamilian@yahoo.com 4600319475328460068069 4600319475328460068069 Yes Department of Gynecology, Arak University of medical science, Arak, Iran. گروه زنان، دانشگاه علوم پزشکی اراک، اراک، ایران. Masoomeh Heydari معصومه حیدری 4600319475328460068070 4600319475328460068070 No Department of Gynecology, Arak University of medical science, Arak, Iran. گروه زنان، دانشگاه علوم پزشکی اراک، اراک، ایران