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Introduction: Impressive research demonstrate the importance of essential fatty acids for many physiological and behavioral mechanisms in both humans and animals. Essential fatty acids must be supplied via the diet. In this study the dietary effect of cis and trans fatty acids on seizures induced by Pentylenetetrazol (PTZ) in second generation of rats is studied. Materials and Methods: In this experimental study animals were divided into four groups. In the three case groups cis, trans, or cis+trans fatty acids were added to the standard food of rats and in control group only standard food was dietary administrated. After one month, kindling was established in rats with PTZ in subconvulsive dose (45mg/kg i.p.). Convulsing activities were monitored for 20 minutes. Five stages of convulsing activities were observed. If after three consecutive sessions the animal was in the fifth stage, it was considered as a kindled animal. Data was analyzed using K-S, t, Tukey tests and analysis of variance. Results: Results showed that the convulsion stage in trans group was significantly more than the others. Also it was found that duration of the fifth stage in trans group was significantly more than control and cis groups. Conclusion: Results suggest that, administering sis and trans fatty acids have some effects on PTZ induced kindling in second generation of the rats who were kindled before. More severe seizure and longer duration of seizure was seen in trans group comparing to cis

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Introduction: Many research demonstrate the effect of margarine trans fatty acids on many physiological mechanisms in both human and animals. The purpose of this research was to evaluate the effects of margarine oil on reproduction in Wistar rat. Materials and Methods: ‏This is an experimental study in which 46 Wistar female and male rats were divided into 4 groups. Male and female rats in group 1 were fed by 3% Margarine oil and standard food, in group 2 only female rats and in group 3 only male rats had Margarine oil with the standard food. Male and female rats in group 4 (as control group) had only standard food. Administration was started one month pre mating and continued during mating, gestation and lactation periods. After delivery, the pups were assessed for overall number, sex ratio, body weight, and mortality. One way analysis of variance was used for data avalysis. Results: ‏Results showed that weight and female ratio of pups were significantly increased in group 2 as compared to group 1 and control. Also the comparison of pups’ mortality in the four groups showed that pups mortality was increased in group 2 as compared to the other groups. On the other hand there was no significant difference in number of pups in the four groups. Conclusion: The results showed that dietary Margarine oil administration to female rats can significantly increase weight, ratio of female pups and mortality of pups.