---

Introduction: Saffron (crocus sativus L.), an important spice rich in carotenoids, is used in folk medicine to treat numerous diseases. This study examines the effects of saffron consumption on innate and humoral immunity of healthy male students.
Materials and Methods: 41 healthy volunteered university students in two control and case groups were included in this study and consumed respectively milk and milk containing saffron for 6 weeks. Blood samples were collected from the subjects at weeks 0, 3 and 6. Innate immunity was evaluated by determining the percentage and counts of monocytes, neutrophils, eosinophils, basophils, platelets and the total white cells, CRP concentration and C3 and C4 concentrations and humoral immunity was assessed by deterning the percentage of lymphocytes and the concentrations of IgG, IgM and IgA.
Results: Three weeks after saffron consumption, monocytes percentage and IgG concentration increased significantly (P<0.05, P=0.01). Total white blood cells and platelets count also reduced significantly (P<0.05). After 6 weeks, monocytes percentage and IgG concentration reduced significantly (P<0.05, P< 0.001) and platelets count increased significantly (P<0.05) as compared with week 3.
Conclusion: This investigation demonstrated that saffron consumption enhances innate and humoral immunity systems and has anti-inflammatory effects. These effects depending on the duration of saffron consumption.

---

Introduction: Infertility is an emotional crisis with physical, economic and psychosocial challenges, because it interferes with all personal life aspects. This event is a sever tension of life and produces strong emotional shock in the infertile couple. This study is done with the aim of comparison the psychiatric problems of infertile men and women referring to infertility clinic of Hamadan Fatemyeh Hospital. Materials and Methods: This is a cross-sectional analytical study. Sample size was 400 infertile men and women which were selected by convenience sampling. Data was collected by a demographic questionnaire and SCL90, and analyzed through descriptive statistics and independent T test. Results: Our study indicates that infertile women experience mental problem significantly more than men. With p<0.05 infertile women in 9 categorize of SCL90 including depression, anxiety, phobia, psychosomatic, interpersonal sensitivity, hostility, paranoid ideation and psychotics are significantly different from infertile men. Conclusion: It seems women experience more stress in personal, social and sexual life and women are more sensitive to infertility phenomena that probably is due to cultural problems, mental susceptibility and/or special forms of social communication

---

Introduction: The reason of infertility can have a direct influence on the plan and outcome of management. In this paper we intend to show the effect of tuberculosis (TB) history on female infertility among infertile couples attending to Rooyan infertility management center. Materials and methods: In this case-control study our cases were those who were diagnosed as infertile female and controls were those women whose husbands were infertile due to some male factor. We used logestic regression for analyzing the association of history of Tuberculosis and female infertility with attributable risk estimation. Results: 308 cases were compared to 314 controls. Considering the odds ratio and its 95% confidence interval, there was a significant difference between the history of TB and infertility (OR=4.7, 95% CI: 1.01-29.91). The attributable risk of TB for female infertility was 0.023±0.01 (which is significant at 5% level). Conclusion: These figures show that at least 2% of female infertility can be prevented by prevention and proper treatment of tuberculosis.

---

Background: Primary dismenorrhea or painful menstruation, in the absence of any specific pelvic diseases, is one of the most common complaints in women’s medicine. The main goal of this study is to examine the effect of isometric trainings on primary dismenorrhea. Materials and Methods: In this quasi-experimental Stud, 30 female students from Payame-noor and Azad Universities in Golpaygan were randomly assigned into two exercise and non-exercise groups. The exercise group did 8 weeks of isometric exercises under the supervision of a physical education expert. The trainees were examined based on the intensity and duration of pain, the amount of bleeding, and consumption of drugs in the first period of menstruation (pre-test), the second period of menstruation (mid-test) and the third period of menstruation ( post-test ). Results: Intensity of pain in the exercise group decreased after 4 weeks (p<0.05) while the duration of pain declined after 4 weeks (p<0.05) and 8 weeks (p<0.01). Also, the amount of taken drugs decreased after 8 weeks of exercise (p<0.05), but the degree of bleeding did not change significantly (p>0.05). Conclusion: Isometric exercises decreased intensity and duration of pain, and the amount of drugs taken in primary dismenorrhea. Therefore, such exercises can probably be used in the treatment of primary dismenorrhea.

---

Background: There is growing evidence that damage to spermatozoa by reactive oxygen species (ROS) plays a key role in male infertility. This study was done to review the role of oxidative stress in male infertility. Materials and Methods: In this review article, PubMed, Scopus, and EBSCO-CINAHL databases were used for finding the relevant studies. Results: Under physiological conditions, a certain level of ROS is necessary for normal sperm function. However, an excessive level of ROS produced by leucocytes and immature sperms can cause damages to spermatozoa. Oxidative stress develops when there is an imbalance between ROS production and antioxidant defense system in male reproductive tract. High levels of ROS have been detected in the semen samples of 25-40% of infertile men. Oxidative stress can induce detrimental effects on standard seminal parameters and fertilizing capacity of spermatozoa. Conclusion: Oxidative stress can induce impaired sperm function that results in poor pregnancy rate in natural conditions and assisted reproduction.

---

Background: Urinary incontinence is a very common problem affecting the quality of life of many people, especially women. Hence, this study was done to investigate the results obtained from intravaginal slingplasty (IVS) method in treating stress urinary incontinence (SUI) in patients.

Materials and Methods: This retrospective study was carried out as census on female patients suffering from SUI who had been treated using IVS method in Najmieh Subespeciality Hospital, Tehran, during 2004-2009 years. Data were extracted through interviews and from patients’ medical records. Descriptive statistics (mean and percent) and inferential statistics (independent t-test and its exact version, Bootstrap, Chi-square test, and Fisher’s exat test) were utilized and data were analyzed using SPSS software.

Results: A total of 357 women with mean age of 45.18±8.78 years participated in this study. Recovery rate of emergency and stress-related SUI by IVS method were 80.1% and 98%, respectively. In addition, urgency SUI had statistically significant correlations with diabetes, blood pressure, age, total number of deliveries, and normal vaginal delivery (NVD). Also, stress-related SUI had significant correlations with post-void residue (PVR), total number of delivery, NVD, and cesarean section.

Conclusion: Generally, it can be concluded that treatment response of IVS in this study is comparable and even better than other existing and customary modes of treatment

---

Background: Heat shock proteins (HSP) are from proteins family playing crucial role in maintaining cellular hemostats and protecting cells in an acute and chronic stressful conditions. The object of this study is to investigate the alternation of heat shock proteins (HSP70) levels after Wingate and Strand tests in female students.

Materials and Methods: In this semi- experimental study, 40 female (20 athletics and 20 non-athletics) with the mean age 22.3±3 & 23.2±2, Height 159.2±5 & 161.2±4 cm and mean weight of 59.3±3 & 65.4±2 kg (respectively) were selected randomly and underwent training protocols of Wingate and Strand tests with 3 days intervals. 5 cc brachial vein blood samples were taken immediately before and after performing tests in order to analyze the data using repeated measure method.

Results: The findings showed significant increase after aerobic Strand test between athletics and non-athletics Female (p<0.01). But, after aerobic Wingate test, a significant increased was observed only in Athletes' group (p>0.05). But there was an insignificant reduction in non-athlete group.

Conclusion: The results showed that exercise duration is more important than exercise intensity in HSP70 production.

---

Background: Fluoxetine or Prozac is a serotonin reuptake inhibitor (SSRI). Considering the importance of this drug for the treatment of neurological disorder, such as anorexia and depression its side effects on the endocrine axis of body are of significance. Hence, the present study was conducted to evaluate the effects of fluoxetine on cortisol and thyroid hormone levels and body weight in male rates.

Materials and Methods: In this experimental study, 30 adult male rats (230±20 gr BW) were randomly divided into 3 equal groups: sham, control and treatment. Rats in the control group were kept in normal conditions in animal house, whereas treatment and sham groups were, respectively, injected 32 mg/kg BW of fluoxetine and 0.9 ml of normal saline (i.p) for 35 days. During this time, body weight of all animal was measured and after 35 days, blood was collected by heart puncture and separation of serums to evaluate T3, T4, fT3, fT4, and cortisol hormones through RIA method. The results were statisticaly evaluated by one-way ANOVA test.

Results: Taking fluoxetine for 35 days significantly decreased the level (p&le0.05) in serum concentrations of Ft3, fT4, T4 and cortisol hormones compared to the control and sham groups. However, no significant differences were observed in the serum concentration of T3 hormone in treatment group compared to the the control group. The drug also caused a significant decrease in the average weight of rats in the treatment group compared to the control group (p&le 0.05).

Conclusion: By affecting the activity of different levels of hypothalamus-pituitary-adrenal hormones axis, fluoxetin decreases the level of cortisol hormones. It also reduces the activity of the thyroid gland this is probably due to the increased prolactin secretion through inhibiting TRH secretion and reducing the production of TSH and thyroid hormones

---

Background: Human &beta-defensin 126 (12kDa) is a small cationic glycoprotein that is highly rich of cysteine. DEFB126 gene is located on the subtelomeric end of 20p1.3 in human. High expression of this protein is reported in epididymis. This polypeptide coats the plasma membrane of sperm during epididy‌mal transit. It is likely that &beta -defensin 126 might have role in unexplained male infertility since it involves in sperm maturation and capacitation. The current research designed to investigate if there is relation between &beta-defensin 126 gene mutation and unexplained male infertility.

Materials and Methods: In this case-control study we followed a two cytosine nucleotides deletion of &beta-defensin 126 gene in 35 Iranian men with unexplained infertility and 40 fertile men with normal spermogeram as control group. Standard PCR, SSCP(Single strand conformational polymorphism), and sequencing were used to detect genetic alteration of &beta-defensin 126. ELISA was performed for the assessment of the protein expression on sperm cells.

Results: Analysis of genetic data revealed 28.6% homozygote deletion in unexplained infertile men while this deletion was detected in 7.5% of controls. The deletion frequency was statistically higher in infertile patients than normal control group (p<0.05). The protein expression was less in men with del/del genotype compare to the other genotypes (p<0.005).

Conclusion: Our study shows that this common sequence variation of &beta-defensin 126 takes part in impairment of male reproductive function. Consequently, men with the del/del genotype are significantly less fertile than men who carry the wild type allele.

---

Background: Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months of regular unprotected sexual intercourse. Male infertility affecting 15% of couples. Environmental and genetic factors are involved in male infertility. Paraoxonase (PON) is an antioxidant enzyme which plays an important role in various diseases and is associated with oxidative stress and lipid metabolism. The PON gene family consists of 3 genes, PON1, PON2, and PON3, that located on the long arm of chromosome 7. In this study, the association of PON1 gene polymorphism at position 192 Q/R with idiopathic male infertility were investigated.

Materials and Methods: Blood Samples were collected from 120 patients diagnosed with idiopathic male infertility and 124 control subjects, and genotyped by PCR-RFLP method. To estimate the association between genotype and allele frequencies in cases and controls, P-values were assessed by Chi-square (&chi2) analysis.

Results: We observed a significant difference in genotype distributions of PON1 192 Q/R polymorphism between patients and controls (P= 0.0001). Our findings revealed individuals with the variant QR and RR had a significant decrease risk of idiopathic male infertility (RR: OR= 0.057, 95%CI=0.003-1.08, P= 0.05. QR: OR= 0.288, 95%CI= 0.132-0.394, P= 0.0001).

Conclusion: Our data indicate that the PON1 192 Q/R polymorphism maybe associated with decreased risk of idiopathic male infertility. Although more studies should be considered with larger number of patient and control subjects to confirm our results.

---

Background: Nowadays, the decline in birth rate is one of the most important social problems in developing societies. Infertility is defined as a failure to conceive in a couple trying to reproduce after one year of regular intercourse without contraception. Leptin have been implicated in maintaining normal female reproductive functions, including lactation, folliculogenesis, ovarian steroidogenesis, the maintenance of mammary gland morphology, the development of dominant follicles and oocytes, the maturation of the uterus endometrium, and menstrual cycle regulation. Sinyle-nucleotide polymorphism T>C found in exon 3 leads to substitution of Arg>Trp at codon 1.5 (R105W). In this case-control study, we aimed to evaluate the association of this polymorphism and the risk of female infertility in the population of Guilan.

Materials and Methods: Blood Samples were collected from 86 patients diagnosed with female infertility and 60 control subjects, and genotyped by allele-specific PCR (AS-PCR). To estimate the association between genotype and allele frequencies in cases and controls, Chi-Square analysis was used.

Results: Analysis revealed no significant differences were found in genotype and allele distributions of LEP Arg105Trp between infertility cases and controls (p=0.21, p=0.2) in this population.

Conclusion: Our findings indicated no significant association between the Arg105Trp polymorphism and female infertility risk (p=0.21). While, more studies are needed to confirm the results.

---

  Background: Approximately, 50% of male infertility causes have remained unknown. It seems that genetic disorders may lead to many cases of idiopathic infertility. XRCC1 ( X-ray Repair Cross Complementing group 1) acts as a scaffolding protein in the base excision repair (BER) and single strand break repair (SSBR). Single nucleotide polymorphisms (SNP) of XRCC1 may influence DNA repair capacity. Thus, they had been considered as a risk factor for infertility. XRCC1 Arg399Gln polymorphism was located on p rotected domain , BRCT1 . The aim of this study was to explore the p ossibility of association between XRCC1 Arg399Gln polymorphism and susceptibility to idiopathic male infertility.

  Materials and Methods: In this case-control study, the genotype and allele frequencies of Arg399Gln polymorphism were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) on a Guilanian population consisting of 144 men with idiopathic infertility and 166 healthy men. Statistical analysis was performed using the MedCalc 12 software.

  Results: According to our results, compared with Arg/Arg genotype, the Arg/Gln , Gln/Gln and Arg/Gln + Gln/Gln genotypes showed a significant association with an increased risk of idiopathic male infertility ( OR=4.19 95%CI 2.37-7.41, p<0.0001 ), (OR=3.42 95%CI 1.50-7.81, p<0.0034), (OR=4.06 95%CI 2.32-7.09, P<0.0001) , respectively. In addition, the Gln allele frequency in patients was significantly higher than that in controls(p=0.0004).

  Conclusion: In total, Arg399Gln polymorphism of XRCC1 gene can be associated with male infertility and Gln allele might be a risk factor of idiopathic male infertility in in this sample population. Larger population and different ethnicities should be studied to achieve a definitive conclusion.

---

---

---

Background and Aim: Food restriction (FR) affects on depression and anxiety behavior. Previous studies have pointed to the role of sulpiride in the treatment of depression and anxiety. The purpose of this study was to determine the role of dopaminergic system and food restriction on depression and anxiety. Materials and Methods: Forty two adult male Wistar rats (180-220g) were divided into 7 groups including: control, sham, 25%, 50%, 75% FR, 75% FR with sulpiride and sulpiride(50µg/rat). The treatment period was 21 days. Day 19 surgery and cannulation was performed and Sulpiride was injected intracrebroventricularly (icv) on the 21st day. Depression and anxiety tests (Tail suspension test and Elevated Plus Maze), was taken from the rats on the 21st day. Data were analyzed by ANOVA test. Ethical Considerations: Ethical points were observed according to the declaration of Helsinki and acts of Bioethics Committee at Urmia University (Ref No: AECVU-180-2018). Findings: Mobility time in FR groups and sulpiride compared to control and in 75% with sulpiride compared to 75% had significant increase. immobility time in FR and sulpiride had significant decrease compared to control. Open arm entry in 75% FR had significantly decreased compared to control and in 75% FR with sulpiride had significantly increased compared to 75%. Open arm spend time in 75% FR with sulpiride had significant increase compared to 75%. Motor activity was reduced in FR groups and injection sulpiride. Conclusion: It seems that sulpride and FR play a role in improving semi-depression circumstances. Sulpiride also play a role in controlling the anxiety behavior induced by FR.

---

---

Extended Abstract
Introduction
Nurses, as the main force and the most important bearers of the health system, have a fundamental role in continuing care. Married female nurses, in addition to taking jobs full of stress and high burnout, should play other roles such as mating and motherhood. Therefore, this pressure, stress and exhaustion is more evident. Therefore, in order to reduce these problems, the increase of resilience in this group is more than before. In recent years, the positive psychology approach, with the slogan of attention to human talents and abilities, has been considered by researchers. The factors that make the human more compatible with the needs and threats of life are referred to as resilience; resilience is the most fundamental constructs under research in this approach which has a special place, especially in the field of developmental psychology, family psychology and mental health.
Method
The present study is based on the fundamental purpose and in terms of the method of collecting descriptive data of correlation type with structural equation model. The statistical population of the study included all married female nurses in public hospitals and medical centers of Alborz province in 1401. A sample of 400 people was selected through multistage cluster sampling. Questionnaire of Resilience of Connor and Davidson (2003),Cognitive emotion regulation questionnaire of Granfsky et al. (2001) and Bagaroozi's Marital Intimacy Questionnaire (2001) were used.In this research, frequency distribution table (to study the characteristics of subjects, descriptive statistics (frequency, mean, standard deviation, minimum, maximum, skewness, elongation) and structural equation modeling (measurement model and structural equation model) have been used using SPSS 26 and Amos24 software.
Results
the results of demographic information based on age (20-25) year, 152 people) 38%; In terms of education (bachelor's degree 265 people, 66.25 percent, based on the number of children, no children with 144 people). 36%, employment history (up to 5 years of experience, 198 people, 49.5% based on the duration of marriage, up to 5 years of marriage, 166 people, 41.5%) as well as the highest number of cohabitation differences (382 people). 95.5% constituted the largest percentage of participants. Cronbach's alpha, cognitive emotion regulation was 0.84, marital intimacy was 0.87, and resilience was 0.81. Also, the variables of standard deviation, skewness and kurtosis, the variable of cognitive regulation of emotion - 0.680, - 0.195 and - 0.905, the variable of marital intimacy 89.597, - 0.887 and - 0.019, and the variables of resilience, respectively - 0.055, 202 -0.0 and 1.131 were obtained. Also, the correlation matrix between the variables of cognitive emotional regulation, marital intimacy and resilience was obtained at 0.01 (, 0.729 and 0.796) and a positive and significant relationship was obtained between the variables, so it was possible to check the research model.
Structural model path coefficients of pathways (cognitive flexibility to marital adjustment, cognitive flexibility to resiliency 0.986, cognitive emotion regulation to marital adjustment, cognitive emotion adjustment to resiliency 0.875, self-differentiation to marital adjustment, self-differentiation to resiliency 0.842 and marital adjustment to resiliency 0.578) all of which were more than 0.5. The standard error of the above paths was 0.091, 0.025, 0.202, 0.253, respectively. 0.035, 0.155, 0.049, 0.035 and 0.049 were obtained. Critical ratios were 5.734, 3.944, 9.810, 3.458, -4.539, 2.450 and 11.795, respectively.  In order to evaluate mediation or mediator relationships in the second model, bootstrap test and for mediation status of mediation analysis was used by bootstrapping method The relationship between cognitive emotion regulation and resilience with mediation of marital adjustment with direct and indirect effects and total effects of which were 0.671, 1.228 and 1.899, respectively. The relationship between self-differentiation and resilience mediated by marital adjustment with direct and indirect effects and total effects of which were 0.479, 0.899 and 0.420, respectively.
Conclusion
The aim of this study was to investigate the modeling of resilience based on cognitive flexibility, cognitive emotion regulation and self-differentiation with the mediating role of marital intimacy. The results showed that direct path coefficient of cognitive flexibility, cognitive emotion regulation, self-differentiation and marital intimacy were directly and mediated by marital intimacy were significant on resiliency (2,5,3). It can be argued that the more couples have control over their emotional leaders, the more they can acquire a positive self-concept and act independently, and in different individual, social and occupational situations, the more able to control their emotions, and they can also establish their own position in these situations and take into account the undependency and in their relationships with others about their emotions and Their emotions are more controllable. (4(Therefore, the more decisions people make based on logic, reasoning, comprehensive view of circumstances, rationality and free from false emotions and emotions, and in their choices different cognitive, emotional, emotional and behavioral factors are more appropriate and free from excesses and considering the interests of the family, rather than individual ones, the more they can tolerate problems. Therefore, in explaining the results of the research, it can be stated that marital intimacy can be the connecting link to increase resilience of flexible couples, differentiated and with more emotional regulation. Limitations of this study can be mentioned to long administrative hierarchy for obtaining permission for sampling and also caution in generalizability of the findings.
Compliance with research ethics
Participants in the study were assured that their information would be preserved. The informed consent form was given to everyone and the participants signed the form. This research has an IR ethics committee code. ZUMS. REC.1401.297 is from Alborz University of Medical Sciences.
Sponsor
According to the authors, there was no financial support for the research. 
Conflicts of interest
According to the authors, this article does not conflict of interest
Thank you and Appreciate
The authors of the article are sincerely grateful to the research deputy of Islamic Azad University of Saveh, the authorities of Alborz University of Medical Sciences, colleagues of health centers in Karaj and all female nurses participating in this research.

 

---

Introduction: Resilience is a component that plays a meaningful role in enduring the hardships of the work and marriage environment. Therefore, it is identified as the main structure of personality, so it is influential to identify variables that can predict resilience.
Methods: The current research is based on the fundamental goal and the descriptive data collection method of the structural equation model correlation. The statistical population of the research consists of all married female nurses of hospitals and government treatment centers in Alborz province in 1401, who were selected by a multi-stage cluster sampling method of 400 people from different treatment units and departments. In this research, the Conner and Davidson resilience questionnaire (2003), Dennis and Vanderwaal cognitive flexibility scale (2001), and Bagaroozi marital intimacy scale (2001) were used to analyze data from Amos version 24 software.
Results: For cognitive flexibility leading to marital intimacy, the value was 2.023. The value for the path of mental flexibility to resilience was 0.986, and for marital intimacy to resilience, it was 0.909. The critical ratio between cognitive flexibility (r= 0.767) and marital intimacy
(r = 0.796) had a positive and significant relationship with resilience at a significance level
of 0.01.
Conclusions: The results showed that the data fit the conceptual model of the research. Also, the mediating role of marital intimacy between cognitive flexibility and resilience was confirmed. According to the results obtained, to increase the resilience of married female nurses, it is suggested to health officials to Different cognitive, emotional and emotional variables of this group should be given special attention.

---

Introduction: Physical activity causes cardiac hypertrophy by a non-pathological change in cardiac structure, called physiological hypertrophy. Several molecular changes are involved in this process. Insulin-like growth hormone-1 (IGF-1) is an important hormone involved in hypertrophy of cardiomyocytes. Also, the role of GATA4 as a possible gene involved in cardiac hypertrophy is controversial. Therefore, the present study was conducted to find the effect of aerobic and interval training on IGF-1, GATA4 gene, and cardiac tissue.
Methods: Eighteen male Wistar rats (243.72 ± 23.41 g) were randomly divided into control, aerobic, and interval training groups (n = 6). The aerobic group trained for 8 weeks/4 days a week/38 minutes/ 65% of maximum oxygen consumption (VO2 max). The intermittent group trained 8 weeks/4 days a week/5 set/4 minutes/85-90% of VO2 max running with 2 minutes rest between the sets. The weight of the heart and left ventricle, IGF-1 concentration, and GATA4 gene expression were measured 48 hours after the training. The evaluation was conducted with a one-way analysis of variance and Tukey's post hoc test at a significance level of 0.05.
Results: The weight of the heart and left ventricle increased significantly in trained groups. IGF-1 and GATA4 gene expression increased in both the training groups than the control group.
Conclusions: Aerobic and Interval training increases IGF-1, GATA4 gene, left ventricle, and heart weight. Considering the shorter time interval training takes, it seems that interval training is more beneficial than aerobic training.

---

Introduction: Resilience is an influential component of various psychological, emotional, and emotional variables and is substantial in occupational, individual, and family issues research.
Methods: The present study is fundamental in its purpose and descriptive in collecting data; it is a correlational type with a structural equation model. The statistical population of the study also includes all married female nurses in government medical centers and hospitals in Alborz province who were working in 2022, from which 400 people were selected as a sample using a multi-stage cluster sampling method. Connor and Davidson's (2003) resilience questionnaire, the revised short form of the Skorn-Smith Self-Differentiation Questionnaire (2003), and Bagarozzi's (2001) Marital Intimacy Questionnaire were used to collect data.
Results: There is a positive and significant relationship between self-differentiation (r = 0.732,
P > 0.01) and marital intimacy (r = 0.856, P > 0.01) with resilience. Also, the standard deviation, skewness, and kurtosis of the self-differentiation variable were 20.686, 0.212, and -0.941; the marital intimacy variable was 89.597, 887, and -0.019; and the resilience variable was 30.055, 0.202, and -1.131.
Conclusions: The results showed that the data fit the research's conceptual model and also confirmed the mediating role of marital intimacy in the relationship between self-differentiation and resilience. Therefore, it is recommended that healthcare professionals pay special attention to the cognitive, emotional, and affective variables of this group to increase the strength of married female nurses.