Showing 3 results for Major Depression
Bahman Salehi, Saeid Jafari, Fardin Faraji,
Volume 10, Issue 1 (3-2007)
Abstract
Introduction: Nowadays, depression is one of the most prevalent psychological disorders and is a prevalent mood disorder. Recently researches about depression etiology, show that in addition to different neurotransmitters and life events, internal stressors such as serum cholesterol, triglyceride and some coagulation factors can have an effect. This study was focused on the relationship between major depressive disorder and serum cholesterol level. Materials and Methods: This research is a case control study that was performed in the year 2006. Case group were 62 patients referred to Hashemi Senejani psychiatric medical center and control group were chosen from ENT ward patients of Amir-Kabir hospital. Both groups were paired match for age, gender and education. In order to determine serum cholesterol level, 5cc blood sample was taken of each person from both groups. Data was analyzed using K-S and Mann-Witheny U tests. Results: The mean age of samples was 35.5±9.9 years. 77% were female, 67.2% married, 25.8% single and 6.5% divorced. Average serum cholesterol level in case group (215.6 ± 47.6 mg/dl) in comparison to control group (183.1 ± 31.2 mg/dl) was significantly higher (p<0.05). Conclusion: Regarding the results, it seems that serum cholesterol is an internal stressor for depressive disorder so everyone with high serum cholesterol level must be evaluated for depressive disorder.
Azam Davoodi, Hamid Taher Neshat Dust, Hasan Pasha Sharifi,
Volume 14, Issue 4 (9-2011)
Abstract
Background: Different studies have proposed the cognitive deficits as one of the main aspects of schizophrenia furthermore, the presence of psychosis in these patients can influence the degree of deficiency in executive functions .The purpose of this study is to compare the executive function in patients with schizophrenia, non-psychotic major depression and normal individuals.
Materials and Methods: In this cross-sectional study, 28 patients with schizophrenia, 28 patients with non-psychotic major depression and 28 normal subjects were selected from hospitals in Tehran through available sampling method which were matched according to age, sex, and level of education. The executive functions of subjects were evaluated using Wisconsin Card Sorting Test, and data were analyzed using one-way ANOVA and Turkey post-hoc test.
Results: Schizophrenic patients had poorer performance in comparison with non-psychotic depressives and normal individuals in all variables of Wisconsin test (P<0.001). Also, depressive patients showed more preservative error than normal subjects (P<0.001), but no significant difference was found between the two groups in the number of categories and specific error variables.
Conclusion: Greater impairment in the executive functions in the Wisconsin card sorting test is mainly associated with psychosis which might be introduced as a special profile of schizophrenia. Noticing the amount of deficiency in executive functions in each group of patients, the positive or negative prognosis can be diagnosed initially.
Mahbobe Ebadi, Fatemeh Hoseini, Fateme Pahlevan, Mohammad Esmaeilzade Akhoundi, Vahid Farhadi, Roqaye Asqari,
Volume 20, Issue 5 (8-2017)
Abstract
Abstract
Background: The aim of this study was to evaluate the effectiveness of of transcranial direct current stimulation (tDCS) on working memory in patients with major depression.
Materials and Methods: The research method was quasi-experimental with pretest and post-test and follow-up with control group. The research population comprised female outpatient referrals to private psychiatric centers and psychological counseling centers in Tehran in the first half of 2016, They had received a diagnosis of depression by a psychiatrist at least once. Of these, 30 females were selected as a sample group with convenience sampling method and based on the criteria of inclusion and exclusion and were divided randomly into two groups , experimental (n = 15) and control (n = 15) group. The experimental group received transcranial direct current stimulation (tDCS) in 10 sessions, While this intervention was not provided to the control group. The data were collected by N-BACK. Analysis of variance with repeated measurments was used to test the research hypothesis.
Results: The results showed that transcranial direct current stimulation (tDCS) had a significant effect on increasing working memory and the impact will continue to follow up.
Conclusion: Therefore, this approach can be used to improve working memory in people with major depression.
