Showing 22 results for Lipid
Akram Ranjbar, Parvin Pasalar, Ali Reza Sedighi , Mohammad Abdollahi , Jamileh Danesh-Nia ,
Volume 6, Issue 2 (7-2003)
Abstract
Introduction: Production of free radicals and reactive oxygen species is an integral part of aerobic metabolism. Disturbance of the balance between the production of free radicals and antioxidant system against them produces oxidative stress. Paraquat toxicity is induction of oxidative stress. However, the aim of our study was to evaluate oxidative stress in blood samples of workers in a pesticide factory formulating paraquat.
Materials and Methods: In this study we measured lipid peroxidation (LPO) with thiobarbituric assay (TBARS), total antioxident power (FRAP) and SH groups between workers in pesticide factories (case group) and health subjects (control group).
Results: Oxidative stress was significantly higher (p<0.001) in LPO, significantly lower (p<0.001) in TBARS and significantly lower (p<0.001) in SH groups in the case group compared to control group
Conclusion: It is concluded that chronic exposure of workers in their workplace to paraquat producess oxidative stress that could be prevented by well known nutritional antioxidant supplements.
Touba Kazemi, Hossain Panahi Shahri, Maryam Hossaini Farash, Mahdi Darabi, Mohsen Kashanian, Hossain Akbari,
Volume 8, Issue 3 (1-2006)
Abstract
Introduction: Hyperlipidemia is one of the main known risk factors for coronary artery disease. Regarding the undesirable consequences of hyperlipidemia and its long-term treatment, it is important to use drugs with lesser complications during the long period of treatment.
Materials and Methods: This study was a double-blind randomized clinical trail that carried out on 65 patients with hyperlipidemia. Patients were divided into two groups. Case groups took dill pearl, and control group took placebo pearl for one month. Serum lipids of both groups were measured before and one month after interference. Data was analysed with t-test and p<0.05 was considered significant.
Results: In this study , differences between mean level of cholesterol, triglyseride, HDL and LDL in case group before and after interference were statistically significant (P<0/05) but in control group only difference between HDL before and after interference was significant .
Conclusion: Regarding the result of the study dill pearl can be a useful drug for treatment of hyperlipidemia.
Rezvan Ansari, Manije Kahbazi, Morteza Abdare Esfahani,
Volume 10, Issue 1 (3-2007)
Abstract
Introduction: Studies have shown that there is a relationship between metabolic syndrome and coronary heart disease. Hypertension is a common risk factor of both cardiovascular diseases and metabolic syndrome. The aim of this study is to determine the prevalence of metabolic syndrome phenotypes in patients with hypertension in Isfahan and Markazi provinces in center areas of Iran. Materials and Methods: This cross-sectional study was implemented in Isfahan and Markazi provinces in year 2001. Sampling method was random-clustering. 12514 people from both sexes who were above 19 years old were considered which based on ATP III, 1936 person of them had metabolic syndrome. Based on the definition, these people were those who at least had three of the following factors abnormally: HTN, FBS, TG, HDL and WC. Also hypertension was considered for all groups. Data was analyzed using Chi square test and Odds ratio. Results: The prevalence of metabolic syndrome was 0.6% to 7.5% in central areas of Iran. The most prevalent of metabolic syndrome was in hypertensive women with high TG and WC and the least prevalent was in hypertensive men with these two phenotypes: 1-high FBS and WC, and 2-high FBS and low HDL (p<0.05). Overall prevalence of metabolic syndrome in hypertensive people in the most of urban population was more than rural population. Conclusion: Results showed that hypertension is associated with different metabolic syndromes, especially in women with central obesity and dyslipidemia which necessitates more attention in preventing and treatment of the disease in this high risk group.
Mehrdad Roghani, Tourandokht Balouchnejad, Maryam Falahmohamadi,
Volume 10, Issue 2 (6-2007)
Abstract
Introduction: Use of medicinal plants for decreasing blood glucose and lipids to normal level is clinically important. In this respect, Silybum marianum (SM) is a plant that can lower lipid peroxidation and lipids in an experimental model of hyperlipidemia. Therefore, the effect of chronic oral administration of this plant on serum glucose, triglyceride, total cholesterol, and HDL and LDL cholesterol level of diabetic rats was investigated. Materials and Methods: In this experimental study, female rats (n=36) were randomly divided into 4 groups, including control, SM-treated control, diabetic, and SM-treated diabetic groups. The treatment groups received oral administration of plant-mixed pelleted food (6.25%) for 4 weeks. Serum glucose, triglyceride, total cholesterol, LDL and HDL cholesterol levels were determined before the intervention, and at 2nd and 4th weeks after the intervention. Data was analyzed using repeated measure ANOVA, One way ANOVA, student and pairt T and Tukey tests. Results: Serum glucose level in diabetic group was increased in seond and 4th weeks after the intervention as compared to one week before that (p<0.001) and SM treated diabetic rats only had a mild non-significant effect. In addition, triglyceride level in diabetic group increased 4 weeks after the intervention in comparison to related data one week before that (p<0.05) and there was a significant lower level of triglyceride in SM-treated diabetic rats (p<0.05). Furthermore, a similar significant reduction was obtained for treated-diabetic group as compared to diabetic group regarding serum cholesterol level (p<0.05). On the other hand, HDL- and LDL- cholesterol levels were significantly higher (p<0.05) and lower (p<0.05) in SM-treated diabetic group as compared to untreated diabetic group respectively. Conclusion: Oral chronic administration of SM had no significant hypoglycemic effect and led to appropriate changes in blood lipid profile.
Mahsa Yousefinia, Ahmad Amani,
Volume 10, Issue 2 (6-2007)
Abstract
Introduction:Hyperlipidemia is one of the major risk factors of cardiovascular diseases. This study was done to assess lipid profiles according to sex and place of residence in the urban and rural area of Arak for controlling cardiovascular diseases. Materials and Methods:This descriptive study is the first phase of healthy heart program which was done in Arak. Sampling was randomized cluster. A questionnaire was used to collect demographic data and paraclinical test results (total cholesterol, LDL-c, HDL-c ,and Triglyceride). Data was analyzed using T-student, Kolmogorov-Smirnov, Mann-Whitney and Chi-square tests. Results: Of 4303 individuals over 30 years, 51.6% were female. Total cholesterol, LDL-c and HDL-c disturbances were more in female (p<0.05) but there was not a sigmifiant difference between male and female in triglyceride disturbance. The increase in serum lipids was signfiantly different in urban and rural areas, in which total cholesterol and LDL-c disturbances were more in rural and triglyceride disturbance was more in urban areas (p<0.0001). Conclusion: High prevalence of dyslipidemia in the studied region can be related to unhealthy life style, nutrition and inadequate physical activity, so dyslipidemia and cadiovascular diseases could be decreased by changing lifestyle.
Saeid Sadrnia, Ali Chehrei,
Volume 11, Issue 1 (3-2008)
Abstract
Introduction: Left ventriculor hypertrephy (LVH) is one of the complicotions of systemic hypertension. LVH increases probabiltis of cardiac arrhytmia and cardiovasculer event in hypertensive patiants. In addition to hypertension other factors such as dyslipidemia, hyperglicemia and renal failure can cause LVH. This study was designed to investigate the effects of Body Mass Index (BMI) and some laboratory factors on LVH. Materials and Methods: This is a case-control study in which patients in case group (hypertensive patients with LVH) and patients in control group (hypertensive patients without LVH) were compared for BMI, dyslipidemia, hyperglycemia, and elevated Blood Urea Nitrogen (BUN) and Creatinin. Data was analyzed using Chi square test and logistic regression. Results: BMI with, high blood glucose with, high BUN and Creatinin signiticant affect in LVH presentation in hypertensive patiants. Dyslipidemia had not signiticant affect. Conclusion: In this study BMI, hyperglicemia, high BUN and Creatinin affected LVH presention in hypertensive patiant. So it is recommended that these factors be carfuly monitored and and treated.
Hossein Sarmadian, Nader Zarinfar, Ali Fani, Fateme Marjan Mousavi, Farshideh Didgar, Mohsen Khaki, Azadeh Mohammad Bagheri, Maryam Karimi,
Volume 11, Issue 3 (9-2008)
Abstract
Background: Metronidazole has antibacterial and antiparasitic action. Therefore it can use for treatment inflammatory diseases as Crohn. The effect of metronidazole on human’s blood lipids to reducing levels of LDL and VLDL and increasing level of HDL is under investigation. Target of this research is consideration effect of metronidazole on hyperlipidemia case of death such as coronary artry disrase. Methods and Materials: This study is a triple blind clinical trial was done on 100 voluntaries between 25-65 years old. with hyperlipidemia. Samples divided in two equal groups. The first group received metronidazol, 500mg, BID, for 10 days, and control group received placebo with the same dose. Lipids of serum were measured before and after using drugs, then data analyzed by SPSS software. Results: In metronidazol group amount of total cholesterol, LDL and Triglyceride were significantly less than placebo group. HDL’s amount in metronidazole group was significantly more than placebo group. Conclusion: Significant effect of metronidazole on reducing harmful blood lipids and increasing useful blood lipids. It can be suggested a probable candidate in treatment of hyperlipidemia. Maybe it can use with this application. Although it needs to more study by meta analysis to validate this effect.
Iraj Salehi, Mostafa Mohammad,
Volume 12, Issue 3 (10-2009)
Abstract
Abstract Background: Oxidative stress is strongly related to diabetes and its complications. The aim of this study is to evaluate the effect of experimental diabetes on oxidative stress indexes in the heart tissue and effect of regular swimming on it. Materials and Methods: In experimental-practical study, 40 male Wister rats divided to four groups (n=10): control, control with exercise, diabetic, diabetic with exercise. Diabetes was induced by a single dose injection of Streptozotocin (50mg/Kg, i.p). Study time was 8 weeks. At the end of period, rats were anesthetized by Sodium Pentobarbital (50mg/Kg, i.p) and left ventricle dissociated and maintenance in -80 ºC. Super oxide Dismutase (SOD), Glutathione Peroxides (GPX), Glutathione Reductase (GR) and Catalase (CAT) activities as enzymatic antioxidant status and Malonyl Dealdehyde (MDA) level as index of lipid peroxidation of the tissue in superior layer of tissue homogenization were measured. Results: Diabetes induction significantly reduced CAT and GR activities in heart tissue of diabetic rats compared with control. Also MDA level increased significantly in diabetic-non exercised rats compared with control. Total Glutathione level was similar in all groups. Conclusion: Swimming by preventing in reduction of CAT and GR activities and MDA level of heart tissue has beneficial effects in prevention of cardiovascular complications caused by oxidative stress in diabetes mellitus.
Karon Shah Ebrahimi, Azam Sharifi, Afshin Almasi, Ronak Taliei, Babak Izadi , Mohammad Karimi,
Volume 16, Issue 4 (7-2013)
Abstract
Background: Subclinical hypothyroidism is the compensatory stage before overt hypothyroidism. In overt hypothyroidism, risk of ischemic heart disease increases due to elevation of lipoprotein (a) as atherogenic agent, but evidence for subclinical hypothyroidism is one of the controversial issues in researches. According to the atherogenic lipoprotein (a) and other serum lipids, this study is conducted to compare the serum lipoprotein (a) and other serum lipids in patients with subclinical hypothyroidism and euthyroidism.
Materials and Methods: In this descriptive - analytic study, 90 persons (60 with subclinical hypothyroidism and 30 euthyroid state) are participated and these referred to Imam Reza and Taleghani Hospitals which are located in Kermanshah. The sampling method is selected with available sampling methods. After differentiating data by age, sex and underlying disease (liver, kidney, drugs), then they were subjected to determination lipoprotein (a) and other serum lipids profile tests.
Results: In both cases and controls, 16/7% were men and 83/3% were women. Based on results, there is no significant difference between serum lipoprotein (a), triglycerides, cholesterol, HDL and LDL in both statistical groups (p>0.05). Also there is no association between lipoprotein (a) and other serum lipids (p>0.05).
Conclusion: Serum levels of lipoprotein (a) and other serum lipids in young patients with normal weight with subclinical hypothyroidism is not increase, thus it can be concluded early treatment is not necessary for them.
Keyhan Ghatreh Samani, Effat Farrokhi, Morteza Hashemzadeh, Esfandyar Heidarian,
Volume 16, Issue 5 (8-2013)
Abstract
Background: Paraoxonase1 activity shows decline in patients with coronary artery disease. The C to T change in the -107 position of promoter is the most important genetic determinant of serum levels of paraoxonase 1. Study of this polymorphism and its relationship with the type of fatty acid composition of phospholipids in HDL particles can be found in the common pursuit of better medicines and considered in drug treatment.
Materials and Methods: In this descriptive study 265 Patients were selected and divided in two groups based on LDL level (131 in case and 134 in control). Information of subjects were collected from questionnaire and the results of biochemistry and molecular tests. Fatty acids of HDL phospholipids were measured with Gas chromatography technic .
Results: PON1aryl esterase activity, had no significant changes after treatment with lovastatin but paraoxonase activity had more significant increases in the CC genitype of -C/T107 polymorphism. Percent of oleic acid, linoleic acid and icosapentanioc acid in HDL phospholipids were increased by lovastatin.
Conclusion: Treatment with lovastatin in the CC genotype is probably more protective effect against cardiovascular disease. Following treatment, in patients with higher paraoxanase 1 activity Oleic acid and linoleic acid have also increased in HDL phospholipids.
Atefeh Babaei, Javad Arshami, Ali Reza Haghparast, Mohsen Danesh Mesgaran,
Volume 16, Issue 6 (9-2013)
Abstract
Background: Saffron (Crocus Sativus) petals consist of, glycosides, flavonoids, and anthocyanins. Due to the increasing use of medicinal plants in treatment of diseases and identifying their side effects on various organs, this study is to evaluate the effects of Crocus Sativus petals on biochemical blood parameters in male rats.
Materials and Methods: In this experimental study, 30 male Wistar rats with the mean body weight of 215±15 g were randomly assigned into five groups of 6 animals each. Control group received normal saline (10 ml/kg) and treatment groups received 75, 150, 220 and 450 mg/kg body weight of saffron petals extract, for 14 days. Body weight measured in days 0, 7, and 14. At the end of experiment, serum levels of liver function marker enzymes such as AST and ALT, total proteins, albumin, creatinine, cholesterol and triglyceride were assessed.
Results: Compared to control group, ethanol extract of saffron petals significantly increased serum albumin and also significantly decreased levels of serum cholesterol and AST (p<0.05). No significant changes were observed on serum total proteins, creatinine, ALT, triglyceride levels and body weight in control and saffron groups (p>0.05).
Conclusion: Increase in levels of albumin and decrease in liver enzymes may indicate the lack of liver damage. Reduction in cholesterol which is probably due to flavonoid extracts of saffron and no effect on body weight can be beneficial in the use of saffron petals.
Bahram Pourghassem Gargari, Parvin Dehghan, Elham Mirtaheri, Zeynab Faghfouri, Pouran Karimi,
Volume 16, Issue 8 (11-2013)
Abstract
Background: Considering the high prevalence of diabetes and developing cardiovascular diseases via dyslipidemia and inflammation in type 2 diabetic patients, the aim of the present study was to investigate the effects of Oligofructose-enriched inulin on serum lipid concentrations and inflammation in type2 diabetic patients.
Materials and Methods: In this clinical trial, 52 patients with type 2 diabetes were assigned to one of two groups. Experimental group (n=27) received 10g/d oligofructose-enriched inulin and control group (n=25) received 10 g/d maltodextrin for 8 weeks. Dietary intakes, anthropometric measurements, hs-CRP and serum lipids concentrations were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11.5). Paired, independent t-test and ANCOVA were used to compare comparison of quantitative variables.
Results: At the end of study, we observed significant decrease in total cholesterol (28.00 mg/dL, 14.10%), LDL-c (22.00 mg/dL, 21.7%), TC/HDL-c ratio (-0.73, 20.7%) and LDL-c/HDL-c ratio (-0.55, 27.5%) in oligofructose-enriched inulin compared with the maltodextrin group (p<0.05). Changes in concentrations of triglycerides and high-density lipoprotein were not significant in oligofructose-enriched inulin compared to maltodextrin group.
Conclusion: Oligofructose-enriched inulin supplementation with improving in inflammtion and lipid profile help in management of type 2 diabetes and its complications.
Zahra Eslamirad, Reza Hajihossein, Behzad Gorbanzadeh, Amir Almasi Hashianee,
Volume 16, Issue 12 (3-2014)
Abstract
Background: Toxoplasma gondii is an important pathogenic protozoan. This parasite can cause severe infection and may lead to abortion. Abnormal levels of cholesterol and other lipids in blood samples of infected persons have raised some questions on the role of these factors in the pathogenesis of Toxoplasma.This study aimed to measure and compare lipid and testosterone levels and the relationship between them among a selected group of men with and without Toxoplasma gondii IgG antibody.
Materials and Methods: This case – control study was conducted on a group of 20 to 29 years old men referred to the pre-marital clinics in Arak city in 2012. After completing a questionnaire, a blood sample (5 ml) was taken from each subject. Then, required diagnostic tests for toxoplasmosis was conducted. According to diagnostic results, 100 men with Toxoplasma antibodies were defined as cases and another group with equal number but without antibodies was defined as controls. Then, levels of testosterone and lipids in serum of these two groups were measured and compared.
Results: Findings showed that testosterone levels were in normal range in both cases and controls, but the hormone level was significantly lower among cases. There was no significant difference in terms of serum lipid levels.
Conclusion: Examination of relationship between blood testosterone and lipids levels among cases and controls showed that there was a significant negative correlation between testosterone and triglyceride levels. Also, there was a significant positive correlation between testosterone and HDL levels.
Elnaz Vaghef Mehrabani, Leila Vaghef Mehrabani, Sharareh Norouzi, Somayyeh Ziyadi, Aziz Homayouni Rad,
Volume 18, Issue 9 (12-2015)
Abstract
Background: Metabolic syndrome, a concurrence of overweight and abdominal fat distribution, disturbed glucose and insulin metabolism, mild dyslipidemia and hypertension is among the most important issues that man deals with, in today's world. Probiotics are live microorganisms which, when administered in adequate amounts, can confer a health benefit on the host. The aim of the present study was to review the clinical evidence available regarding the role of probiotics in improvement of disorders associated with metabolic syndrome.
Materials and Methods: In this research, clinical trials performed between 2000-2014 were searched in two databases, Pubmed and ScienceDirect. In both databases “Probiotics”, “metabolic syndrome” and each of its elements were used as the key words.
Results: Probiotics may reduce body weight through manipulating the gut flora. Through reducing inflammation and immune-regulation, probiotics decrease insulin resistance. They also improve lipid profile through reducing cholesterol absorption and producing short chain fatty acids, as well as deconjugating bile acids and converting cholesterol to coprostanol. Moreover, probiotics have been suggested to have a hypotensive effect through release of angiotensin-converting enzyme inhibitory peptides, through proteolytic action.
Conclusion: Although some clinical trials have failed to obtain beneficial effects of probiotics on metabolic syndrome related situations, a majority of the studies have shown positive results for these microorganisms in this regard. Thus, probiotics can be looked upon as a novel approach when either prevention or alleviation of metabolic syndrome is aimed.
Leila Vesaliakbarpour, Mohammad Ali Samavatisharif,
Volume 19, Issue 4 (7-2016)
Abstract
Background: Endurance training can lead to tissue damage and destruction by creating oxidative stress. But, it seems that exhaustive and endurance swimming indicated different results with each other. The purpose of this research was to compare two kinds of endurance swimming training on levels of LDH, CK and MDA in male Wistar rats.
Materials and Methods: 18 male Wistar rats with 12 weeks old, weighting 250 to 300 g, were randomly divided into three groups (6 in each): 1) endurance swimming (EN), 2) exhaustive swimming (EX) and 3) Control (C). Both groups swam for 1 h/d and 5 d/w for 10 weeks. Swimming duration in EX groups was increased progressively by fiveth weeks, by 30 min/week, reaching 3 h/d by final 3 weeks of traninig protocol. In this duration, C group didn't receive any intervention. One day after the end of training protocol, blood samples of rats were obtained on vena cava. The activity of lactate dehydrogenase (LDH) and creatine kinase (CK) was measured with DGKC method and malondialdehyde (MDA) through reaction with TBA. Results were analyzed using the one- way ANOVA followed by a Tukey test. Significant level was 0.05.
Results: EN groups significantly increased the levels of CK compared with EX and C groups (p=0.001), when indicated significantly lesser levels of MDA than C group (p=0.011). But, no significantly difference observed in the levels of LDH.
Conclusion: It seems that endurance swimming creates more muscle damage, while were generates lesser lipid peroxidation.
Mojtaba Asgari, Masoumeh Asle-Rousta, Mohammad Sofiabadi,
Volume 20, Issue 5 (8-2017)
Abstract
Abstract
Background: Diabetes is the most common endocrine disorder that leads to hyperglycemia and hyperlipidemia. Royal jelly is as a bee-collected natural product has diverse biological properties and that is rich in natural antioxidants. The aim of this study was to investigate the effects of royal jelly on serum glucose and lipids profile in streptozotocin induced type 1 diabetic rats.
Materials and Methods: In this experimental study, 40male Wistar rats were divided into 5 groups(8 in each): control, diabetic rats, Glibenclamide, and two groups of royal jelly- treated diabetic. Diabetes was induced in the rats by injection of streptozotocin (60 mg/kg b.w) intraperitoneally. The royal jelly was gavaged at doses of 100 and 200 mg/kg after streptozotocin injection for30 days. At the end of this period, levels of glucose, cholesterol, triglyceride, LDL and HDL in serum were measured.
Results: Royal jelly and Glibenclamide significantly decreased the levels of glucose, cholesterol, triglyceride and LDL in diabetic rats (p<0.01). In addition, significant increase (p<0.01) in HDL level was observed in royal jelly-treating rats in comparison to the diabetic rats.
Conclusion: The results indicated that royal jelly may be used effectively in controlling and attenuating the complications of diabetes. The hypoglycemic and hypolipidemic effects of royal jelly may be due to the presence of antioxidants.
Mohsen Salesi, Mohammad Mehrtash, Farhad Daryanoosh, Nader Tanide,
Volume 21, Issue 5 (10-2018)
Abstract
Background and Aim: Excessive fat accumulation is one of the most important mechanisms of type 2 diabetes and insulin resistance. Accordingly, in this study, we will examine the effect of caloric restriction on lipid coat proteins that prevent lipolysis of the adipose tissue.
Materials and Methods: In this study, 30 adult male Sprague-Dawley rats (200 ± 20 weight) were used. First, rats were divided into 2 groups (standard and high-calorie diet). After 8 weeks, the high-calorie diet group was randomly assigned to two subgroups: caloric restriction and high-fat diet. Finally, the amount of perilipin 1 and 5 genes expression evaluated by Pcr and insulin resistance evaluated by HOMA index.
Findings: The weight and insulin resistance of the high-fat diet group was significantly higher than the standard and calorie restriction group (p≤0.005). Insulin resistance was not significantly different between the caloric restriction and standard group (p = 0.394). The expression of perilipin 1 in the adipose tissue of the high-fat diet was significantly higher than the caloric restriction group (p ≤0.005). The expression of perilipin 1 gene in skeletal muscle in the high-fat diet group was significantly higher than the calorie restriction and standard diet groups (p≤0.005). The calorie restriction group had more perilipin 5 expressions than the high-fat diet and the standard group (p ≤0.005).
Conclusion: The caloric restriction may be due to the effect on lipid coat proteins and, as a result, a decrease in fat accumulation, that it can prevent insulin resistance.
Saeed Changizi-Ashtiyani, Majid Ramezani, Hossein Poorcheraghi, Seyed Mohammad Afzali, Parand Pirouzi, Sina Atashi, Ali Zarei,
Volume 22, Issue 5 (11-2019)
Abstract
Background and Aim Among the plants with multiple healing properties and a long and common history of use in Iranian traditional medicine, is dog-rose plant with the scientific name of “Rosa canina” that belongs to the Rosaceae family. This study aimed to review the effectiveness of Rosa canina in treatment of different body organs and tissues and emphasizes its therapeutic mechanism.
Methods & Materials This is a review study. About 176 papers published from 2010 to 2018 were extracted from PubMed, Science Direct, Scopus, Google Scholar, Ovid, MagIran, and SID databases using related keywords and entered into study.
Ethical Considerations Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors.
Results Different studies had indicated the importance of Rosa canina as a medicinal plant protecting liver, lowering glucose and lipid levels, and having antioxidant and anti-inflammatory properties. The highest flavonoid activity in the Rosaceae family is related to Rosa canina. The use of herbal extracts in the treatment of common diseases, such as diabetes, fatty liver, urinary tract and Alzheimer's, has been recommended.
Conclusion High qualitative and quantitative diversity of effective ingredients, ease of access, absence of adverse effects of consumption and endemic nature of Rosa canina plant make it necessary to use it for the control and treatment of common human diseases.
Azadeh Safari, Mehdi Moradi, Mojtaba Khansooz,
Volume 23, Issue 2 (5-2020)
Abstract
Background and Aim: The purpose of this study was to investigate the effect of eight weeks of aerobic exercise and the consumption of kefir dough on anthropometric indices, plasma lipid profile and blood pressure in overweight non-athletic women.
Methods & Materials: This quasi-experimental study was performed on 32 non-athletic women with overweight in Arak, Iran (mean age= 33.94±8.58 years, mean height= 1.59±0.05 cm, mean weight= 70.15±6.88 kg, and body mass index= 27.35±1.50 kg/m2) who were voluntarily selected and randomly divided into four groups of 8 (control, exercise, exercise + supplement, and supplement). The control group had a normal diet without exercise; the supplement group received 100 ml kefir dough three meals a day for 8 weeks; the exercise group performed aerobic exercise for 8 weeks, 3 sessions per week, each for 50 minutes. The exercise + supplement group received both aerobic exercise and kefir dough. Blood and anthropometric variables were measured at the beginning and at the end of the intervention. Paired t-test was used to examine the within-group variations and one-way ANOVA to examine the between-group variations. All statistical tests were performed at the significant level of P<0.05.
Ethical Considerations: This study has obtained its ethical approval from the Research Ethics Committee of Qom University (Code: IR.QOM.REC.1398.01).
Results: The combination of kefir dough supplementation and aerobic exercise significantly reduced the mean blood pressure (P=0.003) and BMI (P=0.03) but had no significant effect on total cholesterol (P=0.27), triglycerides (P=0.61), high-density lipoprotein (P=0.16), low-density lipoprotein (P=0.30) and waist-to-hip ratio (P=0.24).
Conclusion: Overweight women can benefit from the aerobic exercise combined with kefir dough supplementation to reduce their blood pressure and BMI. Further studies are recommended to determine the effect of aerobic exercise and kefir supplementation on serum total cholesterol, triglyceride, low- and high-density lipoproteins, and waist-to-hip ratio.
Fatemeh Shahrestan, Parvaneh Jafari, Aram Gharebaghi, Iman Khani Farahani, Esmaeil Shahrestan,
Volume 23, Issue 2 (5-2020)
Abstract
Background and Aim: Diabetes mellitus is one of the leading causes of death, and its prevalence is increasing annually because of the change in lifestyle. Increased blood glucose level and dyslipidemia are the major symptoms of this metabolic disease. Currently, the main and effective treatment for diabetes is the use of medication such as insulin. Its control by using herbal products has received a lot of attention in the world. The aim of this study is to evaluate the effects of bioflora (a probiotic supplement) and aqueous extract of cinnamon in improvement of blood glucose level, dyslipidemia, and reduction of cardiovascular diseases in diabetic rats.
Methods & Materials: Thirty-five male Wistar rats were prepared and randomly divided into five groups of negative control, positive control, probiotic (treated with bioflora 3.2×108 CFUs/day for 30 days), cinnamon (treated with 200 mg/kg of cinnamon aqueous extract for 30 days), and probiotic + cinnamon. Diabetes was induced by intra-peritoneally injection of streptozotocin. The rats’ weight, blood glucose level, lipid profile, high sensitivity C-Reactive Protein (hs-CRP) and Atherogenic Index (AI) were measured at the end of experiment to predict the risk of cardiovascular diseases.
Ethical Considerations: This study ethically approved in Research Centre of Islamic Azad University of Arak (Code: IR.IAU.ARAKREC1397.005). All interventions performed in accordance with the Guide for Care and Use of Laboratory Animals prepared by the Institute of Laboratory Animal Resources.
Results: Induction of diabetes caused severe weight lost in rats, but the weight loss was lower in groups treated with probiotic. The blood glucose level in probiotic + cinnamon group was significantly reduced. Bioflora reduced triglyceride, cholesterol, and Low-Density Lipoprotein Cholesterol (LDL-C) levels, while cinnamon extract significantly reduced triglyceride and LDL-C levels compared to the positive control group. AI and hs-CRP values were reduced in the probiotic group compared to control groups. There was no synergistic effect by combined use of bioflora and cinnamon extract.
Conclusion: Bioflora effectively prevented dyslipidemia by improving intestinal microbiota, lowering blood glucose level, and improving lipid profile and, therefore, reduced the risk of cardiovascular diseases.
