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 Abstract Introduction: Demodex is a genous from family of Demodicidae, order of Prostigmata, Demodex is a genus of tiny parasitic mites that live in or near hair follicles of mammals. Two species living on humans have been identified: Demodex folliculorum that live in or near hair follicles of mammals and Demodex brevis. This diseas in women ocure more than men Case: The patient was a lady with 20 years old, who lives in a village urban of Arak. She was referred with sever itch and hyperkeratosis in cheek to dermatologist. She has referred to clinical pathology laboratory. Several slides have provided from skin of cheek.The density of Demodex was seen under the microscopic study in this patient. Conclusion: The study suggests that patients have referred with itch and hyperkeratosis in head and face may be suffered from demodex infection. Thus it is suggested that demodex diagnosis add to standard diagnosis paradigm.