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Introduction: Oculogyric crisis which is a dystonic reaction, is commonly caused by neuroleptics and rarely occurs with atypical antipsychotics specially Clozapine. In this article a case of Clozapine induced oculogyric crisis is reported. Case: The patient was a 25 years old woman with auditory hallucination, loosening of association and persecutory delusion that was admitted and treated. Because of poor response to typical antipsychotics, Clozapine was prescribed. Then she experienced multiple episodes of oculogyric crisis and was treated successfully with anticholinergic medication (Artane). Conclusion: In this special case, Clozapine caused oculogyric crisis. This side effect is rare but should be considered as a possible adverse effect of Clozapine. On the basis of this report, Clozapine induced oculogyric crisis may be treated successfully with Artane

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Background: Focal dystonia is a chronic disease with unwanted side effects. In addition to physical symptoms, some psychological problems, particularly depression, anxiety and stress are common in patients with focal dystonia. The aim of this study was investigating the effectiveness of medication in comparison to medication plus EMG biofeedback on depression, anxiety and stress in females with chronic focal dystonia.

Materials and Methods: This was an experimental/interventional study with pre, post, and follow-up phases. The sample was consisted of 20 female patients with spasmodic torticollis and 10 patients with blepharospasm. All of the patients have been already diagnosed by neurologist They were randomly selected and assigned into medication and medication plus EMG biofeedback groups. Both of the groups were treated with botulinum toxin type A and the second group in addition to receiving the drug for 10 weeks also participated in 20 sessions of EMG biofeedback treatment. Data were collected through the DASS-42 questionnaire which was completed in the pre-test, post-test, and follow-up phases.

Results: The mean of DASS-42 score in the Medication plus EMG biofeedback group showed a significantly higher decrease compared to the medication group (p<0.05).

Conclusion: The results suggested that medication plus EMG was more effective than medication alone in decreasing depression, anxiety and stress in females with chronic focal dystonia.