Showing 10 results for Cortisol
Bahram Aminmansour, Kambiz Eslami,
Volume 8, Issue 2 (7-2005)
Abstract
Introduction: Different hormonal responses may appear in severe head injured patients (including increase in serum Cortisol & GH level). These changes can also be seen in recovery and rehabilitation periods, so influencing the patients, outcome.
Materials and Methods: Forty severely head injured patients, referred to emergency units of Alzahra & Kashani hospitals were studied in a cohort study (selected by convenient sampling) after dividing into two equal groups. Craniotomy was performed for one group and conservative (non-surgical) therapy for the other. In the first and seventh day of admission serum Cortisol and growth hormone were checked (using RIA method). Data was analyzed by paired and student t tests.
Results: There were significant differences between mean of GH in the first and also in the seventh day(both with P<0.05) and between mean of GH and Cortisol from first to seventh day in two study groups(P<0.05). But there were no significant differences between mean of Cortisol in the first or seventh day in two study groups.
Conclusion: Results of this study showed that craniotomy as an independent factor can raise serum GH and Cortisol levels in severely head injured patients.
Masoud Motamedi, Abbas Atari, Mansour Siavash, Fereshte Shakibaii, Mohamad Masoud Azhar,
Volume 10, Issue 4 (12-2007)
Abstract
Association between biological factors and disruptive behaviors in children and adolescents is important to investigate. Antisocial, aggressive and delinquent behaviors in adults often begin early in life. Basal cortisol is a valuable biological characteristic of children with disruptive behavior disorder (DBD). In this study the effect of family training on basal salivary cortisol in children with DBD was investigated. Materials and Methods: This is a clinical trial study. Basal salivary cortisol levels were studied in 19 children between 8-13 years old with DBD, before and 2 months after intervention (family training). The disruptive behavior of the child was assessed with child behavior checklist (CBCL). Cortisol levels and score of behavior were compared before and after intervention. Data was analyzed using descriptive statistics, paired t-test and pearson correlation. Results: Salivary cortisol before family training was 7.9±4.6 nmol/L and after that was 10.46±3.84 nmol/L which was significantly different (p<0.001). Behavior score before intervention was 72.05±10.10 and after that was 49.361±1.89 that was also significantly different (p<0.0001). Children with lower basal salivary cortisol had a better response to intervention. Conclusion: Parent training is an effective method for behavioral modification in DBD. Salivary cortisol can be considered as a predictive factor for severity of disruptive behavior, also a factor to assess the response to parent training in children with DBD.
Seyed Mohhamad Ali Shariat Zadeh, Ahmad Hamta, Ali Akbar Malekirad, Shariat Zadeh,
Volume 13, Issue 5 (2-2011)
Abstract
Sleep is one of the basic needs of human and any disorder in its natural flow in addition to creating psychological problems can reduce the individual performance. There are descriptions and references about sleep and its features in Quran. In Naba Surش sleep has been referred to as a weakness that indicates a disease state. However, the conditions for the occurrence of sleep can be inferred from Kahf Sura, verse 11, which states: “a major quality of sleep is that one cannot estimate its duration”. In several other verses, sleep is said to be similar to temporary death. Substances such as endorphins, cortisol, and encephalin cause euphoria and have direct impacts on different parts of the body including skeletal muscles that lead to muscle comfort during the day. The amount of secretion of these materials into the body in the morning hours significantly increases. Therefore, waking up early in the morning can bring about euphoria and can have positive impacts which last till the end of the day. According to the findings released by the International Agency for Research on Cancer World Health Organization, men and women who work night shifts are at a greater risk of developing breast cancer and prostate cancer, respectively. Night sleep is a divine blessing that God has endowed people and God in verse 23 of Rome Sura refers to sleep as “one of the signs revealed to people” and asks people to search and investigate about it so as to realize to what extent night sleep can contribute to human perfection and success
Shahnaz Shahrjerdi, Sedighe Darvish Shafighi,
Volume 16, Issue 9 (12-2013)
Abstract
Background: Breast cancer is the most common cancer among women. An important goal for cancer patients is to improve the quality of life (QOL) by maximizing functions affected by the disease and its therapy. This study examined the effects of massage therapy on quality of life in women with breast cancer after surgery.
Materials and Methods: The study was quasi-experimental. Among the 53 women with breast cancer surgery and oncology clinic of Arak, 30 were randomly allocated in two groups of massage therapy (n=15) and 5 weeks (30 min, 2 sessions per week) and control (15 cases). Cortisol levels and quality of life questionnaire (SF36) was redirected and mental health groups. Data analysis software SPSS version 16 using paired t-test and one-way analysis of variance and a confidence level of 95% (p<0.05) was performed.
Results: The results showed a significant increase in the experimental group improved after the massage, physical (p=0.001) and psycho-social (p=0.002) were compared with control subjects. Massage also improves quality of life and mental health in breast cancer patients after surgery was (p<0.05). However, serum cortisol levels between the experimental and control groups were not significant (p>0.05).
Conclusion: The overall results of this study showed that massage therapy can be an effective intervention to improve quality of life and mental health in patients with breast cancer during radiotherapy is used.
Seyyedeh Sara Hashemi, Gholam Ali Jelodar, Alireza Rafati,
Volume 17, Issue 2 (5-2014)
Abstract
Background: Fluoxetine or Prozac is a serotonin reuptake inhibitor (SSRI). Considering the importance of this drug for the treatment of neurological disorder, such as anorexia and depression its side effects on the endocrine axis of body are of significance. Hence, the present study was conducted to evaluate the effects of fluoxetine on cortisol and thyroid hormone levels and body weight in male rates.
Materials and Methods: In this experimental study, 30 adult male rats (230±20 gr BW) were randomly divided into 3 equal groups: sham, control and treatment. Rats in the control group were kept in normal conditions in animal house, whereas treatment and sham groups were, respectively, injected 32 mg/kg BW of fluoxetine and 0.9 ml of normal saline (i.p) for 35 days. During this time, body weight of all animal was measured and after 35 days, blood was collected by heart puncture and separation of serums to evaluate T3, T4, fT3, fT4, and cortisol hormones through RIA method. The results were statisticaly evaluated by one-way ANOVA test.
Results: Taking fluoxetine for 35 days significantly decreased the level (p&le0.05) in serum concentrations of Ft3, fT4, T4 and cortisol hormones compared to the control and sham groups. However, no significant differences were observed in the serum concentration of T3 hormone in treatment group compared to the the control group. The drug also caused a significant decrease in the average weight of rats in the treatment group compared to the control group (p&le 0.05).
Conclusion: By affecting the activity of different levels of hypothalamus-pituitary-adrenal hormones axis, fluoxetin decreases the level of cortisol hormones. It also reduces the activity of the thyroid gland this is probably due to the increased prolactin secretion through inhibiting TRH secretion and reducing the production of TSH and thyroid hormones
Mohammad Mehdi Rafiei, Nader Shavandi, Abbas Saremi, Abbas Shavandi,
Volume 17, Issue 4 (7-2014)
Abstract
Background: There are few studies related to effects of exercise training, including concurrent training, on hormonal changes in children. Hence, the aim of this study was to Compare theeffects of 6 weeks of resistance training and concurrent resistance and endurance training on aerobic power (VO2peak) and resting levels of growth hormone and cortisol in healthy children.
Materials and Methods: The subjects ofthis quasi-experimental study were 35 healthy boys between 9-11 years old, which were randomly divided into three groups of concurrent training (n=12), resistance training (n=11), control (n=12). Experimental groups were trained during 6 weeks 3 times a week.Control group were performed only their routine activities. VO2peak test was taken 48 hours before and after implementation of 6-weeks protocols and samples were selected from all subjects.Measurement of resting levels of GH and cortical was performed with ELISA method. For data analysis, one way ANOVA and paired t-test were used.
Results: The results showed that VO2peak and resting levels of GH increased significantly in concurrenttraining group (p=0.001, p=0.003, respectively). Resting level of cortisol in concurrent group was significantly lower than the other groups (p<0.05) and it was reducedsignificantlyin concurrent training and resistance training groups (p=0.001, p=0.036).
Conclusion: It seems a concurrent training period has greater benefits on VO2peak and resting levels of GH and cortical in children in comparison with resistance training.
Sajad Karami, Majid Kashef, Yaghob Mehri Alvar,
Volume 17, Issue 10 (1-2015)
Abstract
Background: Heat shock proteins (HSP) can act as a cellular protection by facilitating reconstruction of denatured proteins. The aim of this study is evaluation of protective effects of glutamine consumption on HSP70 and cortisol response.
Materials and Methods: In this experimental study, 28 soccer players divided into 4 groups: control (n=7), supplement (n=7), exercise (n=7) and exercise supplement (n=7). Supplements (glutamine) and placebo (Dextrin) to a 0.5 gram per kg of body weight and volume of 5 ml per kg of body weight one hour prior to the exercise protocol was used. exercise protocol include a 3-stage 20-minute run at 80% of maximum heart rate and rest 5 minutes. Blood samples of basal (after 12-14 hour overnight fasting), post exercise, and 90 minutes after exercise were gathered and HSP70 of serum and cortisol were measured with Elisa and RIA respectively. Data were analyzed with multivariate repeated measures (MANOVA) at p&le0.05 level.
Results: There was significant difference in HSP70 amounts between supplement group and exercise supplement group compared to the control group (p&le0.09, p&le0.019) and also supplement group with exercise supplement group (p&le0.032). Also there was significant difference Between post exercise and 90 min after exercise stages compared to basal stage (p&le0.08, p&le0.06) and between post exercise and 90 min after exercise (p&le0.030). In cortisol amounts between basal and 90 min after exercise stages (p&le0.026) there was significant difference.
Conclusion: Glutamine sitimulate of HSP70 induction and combination of supplement with exercise has a great HSP70 response thus athletes who wish to compete or have intense exercise, glutamine consumption is recommended.
Touhid Khanvari, Faramarz Sardari, Babak Rezaei,
Volume 23, Issue 3 (8-2020)
Abstract
Background and Aim: Exercise aerobic is associated with increased creatine kinase and blood lactate immediately after exercise, leading to increased muscle damage and undesirable changes in many cellular markers including serum creatine kinase. In such situations, consuming nutrients and supplements such as coenzyme Q10 may prevent metabolic stress damage by increasing buffering power. However, comprehensive studies have not been performed on the effects of this nutrient on the index of muscle injury and fatigue caused by exercise.
Methods & Materials: For this purpose, 20 inactive volunteer men were randomly divided into two groups of 10-person Coenzyme Q10 supplement (2.5 mg/kg body weight) and quasi-drug (2.5 mg/kg body weight Dextrose). All subjects participated in the Bruce test exercise contract after 14 days of supplementation. Blood sampling was performed in four stages including baseline, after supplementation, immediately after exercise and two hours after exercise. Creatine kinase, lactate and cortisol indices of both groups were measured during these four stages. Data were analyzed by means of standard deviation and repeated measures ANOVA, Bonferroni post hoc and Independent T-test using SPSS V. 17 at the significant level of 0.05.
Ethical Considerations: This article has been approved by the ethics committee of Tabriz School of Medical Sciences with the ethics code IRCT 201203104663N8.
Results: The results showed that 14 days of Coenzyme Q10 supplementation had a significant effect on cortisol level (P<0.05). In addition, one session of exhausting aerobic activity increased creatinine kinase and lactate (P<0.05). On the other hand, creatinine kinase did not differ significantly after exercise (P>0.05).
Conclusion: According to the results of the present study, 14-day supplementation of Coenzyme Q10 may reduce the cellular damage induced by exhaustive aerobic activity in inactive men and prevent an increase in blood lactate levels.
Mr Ali Bazgir, Dr Mohammad Fathi, Dr Rahim Mirnasouri, Ms Rezvan Afshar, Dr Raziyeh Rezaei,
Volume 26, Issue 4 (11-2023)
Abstract
Abstract
Introduction: Insomnia and sleep disorders are related to a decrease in physical and mental health and quality of life. The purpose of this study was to investigate the effect of sleep deprivation on blood sugar, cortisol and insulin levels in athletes compared to non-athletes.
Methods: In this semi-experimental study, 14 healthy men participated in two groups of athletes (7 people) and non-athletes (7 people). One night of sleeplessness (8 hours) was applied to the subjects of both groups. According to the objectives of the research, blood samples were taken from all the subjects in two stages. The data were analyzed using the dependent t test for intra-group comparison and independent t test for inter-group comparison at a significance level of 5%. In conducting the research, the principles of the Declaration of Helsinki, the general guidelines for ethics in research with human subjects and the regulations governing it were observed and the code of ethics was issued by the ethics committee of Lorestan University.
Findings: Insomnia did not lead to a significant difference between the blood sugar and insulin levels of athletes and non-athletes when faced with a (p≤0.05). Also, insomnia did not cause a significant difference in the amount of cortisol between two groups of athletes and non-athletes (p≤0.05). Conclusion: It seems that changes in blood sugar, cortisol and insulin are related to the duration of insomnia and are not affected in short-term and intermittent insomnia.
Keywords: Insomnia, blood sugar, cortisol, insulin, athlete, non-athlete
Toktam Masomi, Doctor Gholamreza Manshaee, Doctor Hadi Farhadi,
Volume 26, Issue 5 (12-2023)
Abstract
Introduction: This research aimed to investigate the effectiveness of combined treatment based on virtual reality and mindfulness on cortisol levels in individuals with generalized anxiety disorder.
Methods: The study employed a semi-experimental design with a pre-test-post-test control group and a two-month follow-up period. The study population included all individuals with symptoms of generalized anxiety disorder who referred to the clinics of the Psychological Services Center and Counseling in Region 3, the Counseling and Psychological Services Center of Welfare in Region 6, and the Aryaz Counseling and Psychological Services of Region 6, Tehran, from April 2022 to the end of autumn 2022.
Results: The sample consisted of 30 individuals (10 males and 20 females) with generalized anxiety disorder, selected purposefully and randomly assigned to a treatment group based on virtual reality and mindfulness (15 individuals) and a control group (15 individuals). Pre-test, post-test, and follow-up cortisol levels were measured, and the Generalized Anxiety Disorder 7-item scale (GAD-7) was used as the entry criterion. Subsequently, the experimental group received an eight-session, 17-minute weekly treatment based on virtual reality and mindfulness. Participants in this group, while immersed in a virtual environment, watched 360-degree virtual reality videos, "Walking by the Beach" and "Pebbles in the Lake," accompanied by mindfulness audio contemplation, "Being Present and Breathing," and "Wise Mind," using a VR headset and VR-ARBOX. The control group received no treatment.
Conclusions: After completing the interventions, post-tests and two-month follow-ups were conducted. The data were analyzed using repeated measures analysis of variance (ANOVA) with SPSS23 software, revealing that the combined treatment based on virtual reality and mindfulness was effective in reducing cortisol levels. It is suggested that this combined method is used as a clinical intervention in order to reduce the level of anxiety and cortisol of people suffering from generalized anxiety disorder alone or along with other psychological and pharmaceutical interventions.
