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Introduction: Staphylococcus Aureus is one of the most important pathogenes in human. Regarding the ability of this bacterium in nasal colonization, carriers can increase the incidence of many nosocomial infections. This study was designed to compare the efficacy of two antimicrobial regimens (topical nasal Mupirocin and oral Ciprofloxacin) in treatment of Staphylococcus Aureus carriers and its recurrence. Materials and Methods: This study is a triple blind clinical trial that was performed on 366 cases of Vali-e-asr hospital personnel. Nasal cultures were prepared from all these cases. Among them, 45 cases were carriers which were divided in two groups (A and B). Group A were treated by single dose of oral Ciprofloxacin (1500 mg) and Vit A+D ointment as placebo for 5 days (twice a day) and group B were treated by single dose of oral placebo and nasal Mupirocin ointmdent for 5 days (twice a day). After this period, nasal cultures were repeated in the two groups to evaluate the efficacy of treatment. Also after 5 weeks the last cultures were performed in order to determine the prevalence of reinfection. Results were analyzed using Chi-square test. Results: Results showed that, 12.9% of Vali-e-asr hospital personnels were nasal carriers of Staphylococcus Aureus. Also the efficacy of topical nasal Mupirocin regimen (89.5%) was significantly higher than single dose of oral Ciprofloxacin regimen (55%) (p=0.019). But there was no significant difference between prevalence of reinfection in topical (13.3%) and oral regiment (20%). Conclusion: According to the present data, it seems that topical Mupirocin therapy is more effective than single dose of oral Ciprofloxacin in treating Staphylococcus Aureus carriers. However there is no significant difference in the prevalence of reinfection between the two methods.

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Background: The Infections that are related to vascular access, are regarded as Important factor in mortality and morbidity in the patients with immune deficiency including hemodialysis patients. Staphylococcus aureus is the most common and most Important organism involved in this regard and it cause bacteremia and its complications in the patients is important. This organism can cause carriage states and its most frequent carriage source is in the nose. The aim of this study is determination of staphylococcal carriage states in the Zanjan hemodialysis patients and control group.

Materials and Methods: This cross sectional study is designed in the patients with chronic renal disease who were referred to the hemodialysis wards. Nasal samples were collected with sterile swabs. Then they were inoculated in the blood agar culture media and incubated at (35-37) degree for (24-48) hours. This method was taken for control group too. The collected data were analyzed with SPSS and Chi-Square statistically methods.

Results: Based on this study, 7.4 percent of patients and 11.1 percent of the control group were nasal carriers of staphylococcus aureus. The results did not show any meaningful statistically difference between the cases and control groups. But a meaningful statistically difference was observed in the Staphylococcus hemolyticus carriages and the nasal carriage of this organism was more common in the women of case group.

Conclusion: Based on our study, we don't find high prevalence rate of nasal staphylococcus aureus carriage among our case group, and It seems this organism isnot an important agent in our hemodialysis wards.