Shahin Ramazi, Majid Motovalibashi, Morteza Hashemzade Chaleshtori, Hamidreza Khazraei,
Volume 17, Issue 2 (5-2014)
Abstract
Background: Allergy is regarded as a multifactorial condition that its onset and severity are influenced by both genetic and environmental factors. Hence, identification of genetic factors involved in allergic rhinitis development and its related phenotypes is a major task in understanding the genetic background of allergic rhinitis. This study was designed to examine the association between IL-18 -607 A/C promoter polymorphism on chromosome 11q22 and allergic rhinitis.
Materials and Methods: In this analytic study, genomic DNA was obtained from the blood samples of 293 patients with allergic rhinitis and 218 healthy controls by standard phenol chloroform method. The IL-18/-607 A/C polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. To analyze the association between genotypes and alleles and the disease in the case group compared with the control group, X2 test was used.
Results: The frequency of the AC genotype of the IL-18/-607 A/C gene polymorphism was significantly greater in allergic rhinitis patients than in controls (p<0.05). By comparing the frequency of AA genotype with other genotypes, OR was calculated as 2.03.
Conclusion: The results suggest that IL-18/-607 A/C polymorphism gene may be one of the factors participating in the pathogenesis of AR or its intermediary phenotypes.
Ali Asghar Ghalenoei, Hossein Ansari, Abolfazl Payandeh, Azizollah Arbabi Sarjou, Gholamreza Soleimani, Ali Meshkinian,
Volume 24, Issue 3 (8-2021)
Abstract
Background and Aim: Genetic and environmental factors are known to be related to the development of childhood Eczema. We aimed to assess the ecological factors associated with the prevalence of Eczema among children using the ISAAC questionnaire.
Methods & Materials: A total of 1600 primary school girls and boys were selected and examined by multistage random sampling in this cross-sectional study. Data were collected and completed using the International ISAAC Questionnaire, including demographic questions and risk factors through interviews with parents, especially the student’s mother. The data were analyzed in SPSS v. 19 software using the Chi-square test and multiple logistic regression.
Ethical Considerations: This study was approved by the Ethics Committee of Zahedan University of Medical Sciences (Code: REC.1397.481).
Results: The prevalence of current Eczema was 10.4% (95%CI: 8.9-11.9). Co-morbidity with Asthma and Rhinitis was 82.8% and 74.5%, respectively. In multiple logistic regression models, history of allergies in family members (OR: 2.35, 95%CI: 1.53-3.59), father snoring (OR: 3.00, CI95%: 1.98-4.55), Keeping any animal in (OR: 1.6, 95%CI: 1.002-2.58), family size (OR: 0.85, 95%CI: 0.68-0.95), exposure to tobacco smoke at home (OR: 2.84, 95%CI: 1.18-6.81), showed a significant relationship with the occurrence of students’ Eczema.
Conclusion: Exposure to tobacco smoke at home, keeping any animal at home are effective factors in the prevalence of Eczema in children. By eliminating these factors, the prevalence of this disease can be reduced. However, the mothers have the most crucial role in screening and early diagnosis of Eczema in school children regarding determinants in this study. According to the results of this study, it is suggested that parents’ education, especially mothers, be emphasized by paying attention to these favorable factors.
