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Showing 2 results for Zinc Oxide Nanoparticles
Study on the Toxicity Effects of Zinc Oxide Nanoparticles on Hematological and Serum Parameters in Mice
Parvin Sheydaei, Abolfazl Bayrami, Yashar Azizian, Shadi Parvinroo,
Volume 19, Issue 10 (1-2017)
Abstract

Abstract

Background: Nanoparticles are used in various applications due to unique mechanical and physicochemical properties such as their increased surface area to volume ratio and quantum effects. This study was designed to investigate the cytotoxic effects of zinc oxide nanopaticles on hematological and biochemical parameters BALB/c mice.

Materials and Methods: In this experimental study, 28 adult male mice BALB/c, were divided into four groups (one control group and three experimental groups). The mice in the experimental groups orally received Zinc Oxide nanoparticles with doses of 50, 100 and 300 mg/kg for 14 days. The control group received distillated water only. On 15th day, some hematological and biochemical parameters were studied on the blood samples collected.

Results: Results showed that Zinc Oxide nanoparticles cause changes in blood cells. In high concentration, nanoparticles increased some of factors such as white blood cells, hemoglubin, MCV and neutrophil and besides decreased amount of RBCs, pLTs, hematocrit, lymphocytes, glucose and kratenin significantly (p<0.05).

Conclusion: The findings showed that zinc oxide nanoparticles cause harmful effects due to the considerable variations in hematological and serum parameters in mice  in a dose-dependent way.


Evaluation of Serum Biochemical and Histopathological Changes in Mice-Diabetic Kidney Followed by Simultaneous Injection of Nanoparticles of Zinc oxide and Thiamine
Ahmad Khaje Gandomani, Rahmat Allah Fatahian Dehkordi, Mohamad Saeed Heidarnejad, Mohsen Jafarian Dehkordi,
Volume 20, Issue 5 (8-2017)
Abstract
Abstract
Background: In this study, the effects of zinc oxide nanoparticles (ZnO NPs) and thiamine on the blood biochemical markers and kidney histopathological changes after experimental diabetes in mice was investigated.
Materials and Methods: For this purpose, 56 mice were randomly divided into 8 groups of 7 each. Two groups of animals as controls (A) and thiamine (G) were considered. Other groups were diabetic by alloxan at a dose of 180 mg/kg. Group B mice were considered as diabetic group. To diabetic mice into Group C and D , ZnO NPs in concentrations of 0.1 and 0.5 mg/kg were intraperitoneally injected. Groups E and F; to these groups of diabetic mice, ZnO NPs in concentration of 0.1 and 0.5 mg/kg along with thiamin (30 mg/l) was injected. ZnO NPs in concentration of 0.1 was injected to group H mice. Changes in renal tissue along with some biochemical parameters were measured.
Results: The results showed that diabetes induced changes in some of the serum biochemical factors (GGT, BUN and creatinine) in rats (p<0.05). However, the administration of nanoparticles and thiamine reduced these negative effects. Exposure to diabetes causes changes in the kidney tissue of the mouse, in the disturbance of scaffolds for tissue integrity clutter, fragmentation of some convoluted tubules and congestion within the connective tissue.
Conclusion: Treatment of the diabetes mice by ZnO NPs and thiamine improves renal histopathologic structure and blood biochemistry levels.

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