Showing 9 results for Vitamin C
Nader Zarin Far, Hosein Sarmadian, Ali Cyrus, Mohammadali Daneshmand, Shadi Pirasteh,
Volume 12, Issue 1 (5-2009)
Abstract
Background: Pyelonephrities is the urinary tract infection. Using supplemental dugs may decrease duration of treatment and hospitalization. We studied the effect of vitamin C on the recovery of symptoms due to pyelonephrities Methods and Materials: In this clinical trial, double blind, study, 64 patients with uncomplicated pyelonephrities were assessed in 2 groups randomly. Case group took vitamin C capsules, and control group took placebo capsules. In both groups, primary treatment was ceftriaxon capsules during hospitalization and they took ciprofloxacin capsules for 14 days after discharging. Symptoms and Urinary analysis were assessed in the first day of administration and then on the 7th and 14th days after discharging. Data were analyzed with Chi-Square test. Results: Mean of fever duration in vitamin C group (1.130.34 SD day) and placebo group (1.560.62 SD day) significantly decrease (p=0.001). There was a significant difference in dysuria duration in vitamin C group 2.191.06 SD day with placebo group (2.971.06 SD day) (p =0.007). In flank pain, nausea and vomiting duration difference was not significantly (p≥ 0.05). Conclusion: It seems vitamin C, as a supplemental drug improves some pyelonephrities symptoms, such as fever and dysuria, decreases of the hospitalization period
Yahya Bigdeli , Ali Heidarianpour,
Volume 15, Issue 4 (9-2012)
Abstract
Background: Peripheral neuropathy is a common complication associated with diabetes mellitus. It has been shown that oxidative stress is an important etiological factor in neuropathy which contributes to its development however, the exact pathophysiology underlying this complication is not fully understood. This study was designed to examine the effect of regular exercise and vitamin C administration on pain threshold in rats. Materials and Methods: In this experimental study, 36 male Wistar rats (220±10 g) were allocated to control and diabetic (control, vitamin C, exercise, and exercise+ vitamin C) groups. Diabetes was induced by the subcutaneous administration of streptozotocin (60 mg/kg). A week after the induction of diabetes, the rats were subjected to swimming training and vitamin C treatment for 8 weeks. At the end of weeks 3, 5, and 8, Tail-Flick test was done on the rats to assess pain threshold. Data were analyzed using SPSS software. Results: Diabetes significantly decreased pain threshold in the rats. Diabetes-induced hyperalgesia was significantly decreased by training and vitamin C. Concurrent effects of training and vitamin C on thermal pain threshold were significantly higher than each of them alone. Conclusion: Regular exercise together with vitamin C administration can be a proper method for preventing thermal hyperalgesia associated with diabetes. Therefore, they can be effective in the treatment and management of pain
Maryam Keiry, Mahnaz Kesmati, Hossein Najaf Zadeh, Seyed Reza Fatemi,
Volume 17, Issue 10 (1-2015)
Abstract
Background: With the increasing use of nanoparticles of zinc Oxide (nZnO) in the industry, the pharmaceutical and chemical industry, the effects of the nanoparticles on opioid dependence and its possible interaction with vitamin C (as an antioxidant agent) has not been indicated. This study aimed to clarify the effect of ZnO nanoparticles on morphine dependence in the presence and absence of vitamin C in CPP method.
Materials and Methods: In this study, adult male mice weighing 25±3 g were used in the groups which received different doses of morphine(2/5, 5, 10 mg/kg, Sc), Nano ZnO (1, 2.5, 5, 10 mg/kg, IP), vitamin C (1, 5, 25 mg/kg, IP) and groups which receiving combination of vitamin C and nano ZnO. All categories received morphine 5 mg / kg, for induction and diagnosis of dependence in CPP.
Results: Nano ZnO concentrations (2.5, 5, 10 mg/kg, IP) caused a significant decrease in morphine CPP (p <0.01, p <0.001) and the 1 mg/kg of nano was ineffective. Vitamin C in doses of 5 and 25 mg/kg decreased the expression of morphine-induced conditioned place preference (p<0.01) and a value of 1 mg/kg had no effects. All doses of ZnO in the presence of ineffective dose of vitamin C showed a stronger inhibitory effect than to alone nZnO in morphine CCP.
Conclusion: The combination of vitamin C and Nano ZnO are more effective to deal with the psychological dependence to morphin and probably can provide a new approach to addiction treatment.
Ali Reza Rostami, Mehrzad Sharifi, Ali Reza Kamali, Masoomeh Kalantari,
Volume 18, Issue 10 (1-2016)
Abstract
Background: Post ischemic myocardial reperfusion can impair CABG outcomes and cause increased mortality, hospital stay and costs. Then, increased oxygen free radicals lead to lipid peroxidation and sulfhydryl group oxidation. The aim of this study is to evaluate whether N-acetylcysteine and Vitamin C as antioxidants could effect postoperative outcomes of on-pump CABG.
Materials and Methods: In this clinical trial, patients who had undergone CABG were studied in 4 groups receiving Vitamin C, N-acetylcysteine, Vitamin C & N-acetylcysteine and traditional drugs. The study population consisted of 50 patients in each group. Data were recorded in a checklist and analyzed by using SPSS 20.
Results: Mean pump time, ICU stay, hospital stay, the distribution of troponin positive serum, arrhythmia and need for reoperation were significantly different between groups. Gender distribution, mean cross-clamp time, serum creatinine level before and after surgery, the need for inotropic drugs and required dose level of it, showed no significant differences between groups.
Conclusion: It seems that the combination of N-acetylcysteine and Vitamin C had a stronger effect on the defference between the mean of pump time, hospital length stay and length of ICU stay versus the administration of N-acetylcysteine or Vitamin C alone.
Hojat Anbara, Hassan Morovvati, Masoud Adib Moradi, Rasoul Shahrooz,
Volume 20, Issue 7 (10-2017)
Abstract
Abstract
Background: Phenylhydrazine (PHZ) as a strong oxidant agent causes variety of toxic effects including alterations in the biochemical and cardiac tissue. The aim of the present study was to investigate the effects of royal jelly (RJ) and vitamin C (vit C) against PHZ-induced cardiotoxicity in mice.
Materials and Methods: Adult male mice were randomly assigned to eight groups of eight mice each. PHZ was administered to four groups of mice at a dose of 60 mg/kg per 48 hours intraperitoneally for 35 days. Three of these groups received vit C (250 mg/kg per day) intraperitoneally, RJ (100 mg/kg per day) orally and vit C+RJ with same doses four hours before PHZ administration, respectively. A vehicle-treated control group and vit C, RJ and vit C+RJ control groups were also included.
Results: RJ and vit C significantly decreased (p< 0.05) the serum level of malondialdehyde and creatine kinase (CK-BM) that had been increased by PHZ. Also, RJ and vit C increased the total antioxidant capacity and supraxoid dismutase serum that had been decreased by induced PHZ. Moreover, RJ and vit C could improve the tissue damages induced by PHZ such as diffused edema, hemorrhage, congestion, hyaline exudates, necrosis and also fibrosis tissue in heart tissue.
Conclusion: It seems that Vit C and RJ can minimize PHZ-induced cardiotoxicity in mouse through oxidative reactions inhibition.
Sana Alboghobeysh, Lotfollah Khajehpour, Mahnaz Kesmati,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: Anxiety is an adaptation response that is created in response to multiple physiological and environmental stresses. It is clear that involvement of various neurotransmitter systems has important role in the anxiety process. Vitamin C is a water-soluble antioxidant that plays a role in many physiological reactions in the body. On the other hand, nicotine, which increases with tobacco intake, has an anxiogenic effect. Naloxone, as an opioid receptor antagonist, also plays an important role in the development of anxiety behavior. The aim of this study was to investigate the role of naloxone-co-administered vitamin C on anxiety induced nicotine.
Materials and Methods: 84 male mice (30 ± 2 gr) were randomly divided into 12 groups. Anxiety test was performed 30 minutes after intraperitoneal injection of drugs by an elevated plus maze apparatus for 5 minutes. Anxiety indices such as percentage of open arm entry (OAE%) and percentage of time staying in the open arm (OAT%) were recorded and evaluated.
Findings: In this research, injection of nicotine (0.8 mg/kg, ip) increased anxiety behaviors. Vitamin C (80 mg/kg, ip) improved the nicotine-induced anxiety. This effect of vitamin C was inhibited by ineffective dose of naloxone (4 mg/kg, ip).
Conclusion: It seems that vitamin C decreases anxiety behavior of nicotine in the presence of opioid receptors. |
Saeed Changizi-Ashtiyani, Majid Ramezani, Hossein Poorcheraghi, Seyed Mohammad Afzali, Parand Pirouzi, Sina Atashi, Ali Zarei,
Volume 22, Issue 5 (11-2019)
Abstract
Background and Aim Among the plants with multiple healing properties and a long and common history of use in Iranian traditional medicine, is dog-rose plant with the scientific name of “Rosa canina” that belongs to the Rosaceae family. This study aimed to review the effectiveness of Rosa canina in treatment of different body organs and tissues and emphasizes its therapeutic mechanism.
Methods & Materials This is a review study. About 176 papers published from 2010 to 2018 were extracted from PubMed, Science Direct, Scopus, Google Scholar, Ovid, MagIran, and SID databases using related keywords and entered into study.
Ethical Considerations Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors.
Results Different studies had indicated the importance of Rosa canina as a medicinal plant protecting liver, lowering glucose and lipid levels, and having antioxidant and anti-inflammatory properties. The highest flavonoid activity in the Rosaceae family is related to Rosa canina. The use of herbal extracts in the treatment of common diseases, such as diabetes, fatty liver, urinary tract and Alzheimer's, has been recommended.
Conclusion High qualitative and quantitative diversity of effective ingredients, ease of access, absence of adverse effects of consumption and endemic nature of Rosa canina plant make it necessary to use it for the control and treatment of common human diseases.
Taha Fereydouni, Saeed Hajihashemi, Parsa Yousefichaijan, Ali Rahbari,
Volume 23, Issue 6 (11-2020)
Abstract
Background and Aim: Deferasirox (Exjade) is an iron-chelating drug used in patients with beta-thalassemia major. Oxidative stress is among f the major causes of nephrotoxicity and its progression. Deferasirox, due to oxidative stress and increased cell apoptosis causes the dysfunction of renal tubules and renal toxicity. According to its antioxidant and anti-inflammatory properties, the present study explored the effect of vitamin C on deferasirox-induced kidney damage.
Methods & Materials: This study was performed on 30 Wistar rats in 3 groups of control, deferasirox, and deferasirox plus vitamin C. To induce the nephrotoxicity, the intra-peritoneum injection of deferasirox (75 mg/kg/day) was used. After taking plasma from the blood samples of the explored rats, we determined the values of Cr, Na+, K+, Mg+, osmolality, and BUN in the obtained plasma and urine samples. The creatinine clearance, as well as the relative and absolute excretion of sodium and potassium, were also calculated. After separating the two kidneys, they were used for the histologic study with Hematoxylin and Eosin (H&E) staining, as well as Malondialdehyde (MDA) and Ferric Reducing Antioxidant Power (FRAP) biochemical studies.
Ethical Considerations This study was approved by the Research Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1396.309).
Results: Cotreatment with deferasirox and vitamin C reduced renal tissue MDA and relative and absolute Na and K excretion and urine osmolarity; this method also increased creatinine clearance and renal tissue FRAP.
Conclusion: The co-administration of vitamin C presented a significant protective effect on the renal toxicity induced by deferasirox. The protective property of deferasirox is because of the antioxidant impacts of vitamin C in reducing oxidative stress and lipid peroxidation.
Mohammad Haddadi, Davood Movahedzadeh, Elaheh Jaghouri, Hamid Robat Sarpooshi,
Volume 24, Issue 2 (5-2021)
Abstract
Background and Aim: Topical supplements and vitamins have often been used to accelerate the healing of burn wounds. This study investigated the effects of topical application of vitamin C solution on burn wounds.
Methods & Materials: This research was performed on 30 patients with extensive second-degree burns on one or two organs with similar burns. The study subjects were randomly divided into the intervention and control groups. The intervention group received topical application of vitamin C solution in addition to silver sulfadiazine ointment in the burn area; however, only silver sulfadiazine ointment was applied in the burn area in the control group. The wounds were examined and scored on days 1, 3, 7, and 14 using the Bates-Jensen Wound Assessment Tool. The collected data were analyzed in SPSS using repeated-measures Analysis of Variance (ANOVA).
Ethical Considerations: This study was approved by the ethics committee of sabzevar university medical sciences. (Code: IR.MEDSAB.REC.1394.60).
Results Eighteen of the 30 examined patients were male and 12 were female. Their Mean±SD age and body mass index were 43.03±11.90 years and 27.82±4.08 kg/m2, respectively.
Conclusion: The repeated-measures ANOVA data indicated that the study groups were significantly different concerning the final mean scores given to the wounds (P=0.047). In other words, the research groups significantly differed in wound healing; thus, topical application of vitamin C significantly improved wound healing in the study participants.
