Showing 13 results for Type 2 Diabetes
Afsane Talaei, Saber Jabari, Mohammad Hassan Bigdeli, Heidar Farahani,
Volume 10, Issue 4 (12-2007)
Abstract
Introduction: Diabetes is the most important metabolic disease in human. The prevalence of both types of diabetes is rapidly increasing ocross the world. Diabetes causes many complications including End Stage Renal Disease (ESRD). Diabetes is responsible for 30% of ESRD. The prevalence of diabetic nephropathy in Iran is also high. Many of these patients are becoming dialysis dependent. Many studies have shown the changes of trace metals’ levels in diabetic patients including Copper, Zinc, Manganese and Chromium. This study evaluates the correlation between urinary Copper and diabetic nephropathy Materials and Methods: This is a case-control study. Samples were selected among type 2 diabetic patients attending to diabetes clinic in Vali-e-Asr hospital in Arak. Diabetic patients were divided in two groups based on microalbuminuria, 42 patients in case and 40 patients in control group. Then the patients were classified based on duration of diabetes into 4 groups and based on the HbA1c into two groups. Then urinary Copper was determined with atomic absorption spectophotometry and compared. Independent t-test was used to analyze data. Results: Patients were 28.1% male and 69.9% female in case group and 37.5% male and 62.5% female in control group. The mean Copper level was 36.14µg /L (14.54-57.74) in case group and 14.77% µg /L (10.17-19.37) in control group. There was a statistically significant difference between the two groups (p=0.003). Conclusion: The results show a positive relation between urinary Copper and diabetic nephropathy and confirmed the results of other studies that reported the elevation of Copper in microalbuminuria. This study also showed that age, gender, duration of diabetes and HbA1c level have no effect on urinary Copper.
Narjes Najibi, Ahmad Reza Dorosty Motlagh, Haleh Sadrzadeh Yeganeh, Mohammad Reza Eshraghian, Milad Daneshi, Samaneh Azizi,
Volume 16, Issue 1 (4-2013)
Abstract
Background: Food insecurity is defined as the limited or uncertain availability of enough food for an always active and healthy life. Diabetes mellitus, one of the most common metabolic diseases, has been associated with significant morbidity and mortality and it is considered a health priority in Iran. Recent studies indicate the widespread prevalence of food insecurity and diabetes mellitus in Iranian society. This study reviews the status of food insecurity and effective socio-economic factors in people with type 2 diabetes.
Materials and Methods: This cross-sectional study was performed on 135 patients, aged between 30 and 55, who had recently been diagnosed with type 2 diabetes. Demographic and socioeconomic characteristics and food insecurity status were assessed using demographic and the 18-item USDA household food security questionnaires, respectively. Physical activity also was evaluated by MET, physical activity questionnaire. Data were analyzed by Chi-square, t-test, and logistic regression.
Results: Prevalence of food insecurity was 66.7%. Food insecurity was significantly associated with economic status, education level, income, having child under 18 years of age, family size, and number of children (p<0.05) however, there was not a significant relationship between food insecurity and occupation, marital status, family history of diabetes, high blood pressure and heart disease, age, and the amount of physical activity.
Conclusion: Considering the higher prevalence of food insecurity in diabetic patients, it can be said that it is likely that the incidence of diabetes is higher in food insecure people.
Bahram Pourghassem Gargari, Parvin Dehghan, Elham Mirtaheri, Zeynab Faghfouri, Pouran Karimi,
Volume 16, Issue 8 (11-2013)
Abstract
Background: Considering the high prevalence of diabetes and developing cardiovascular diseases via dyslipidemia and inflammation in type 2 diabetic patients, the aim of the present study was to investigate the effects of Oligofructose-enriched inulin on serum lipid concentrations and inflammation in type2 diabetic patients.
Materials and Methods: In this clinical trial, 52 patients with type 2 diabetes were assigned to one of two groups. Experimental group (n=27) received 10g/d oligofructose-enriched inulin and control group (n=25) received 10 g/d maltodextrin for 8 weeks. Dietary intakes, anthropometric measurements, hs-CRP and serum lipids concentrations were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11.5). Paired, independent t-test and ANCOVA were used to compare comparison of quantitative variables.
Results: At the end of study, we observed significant decrease in total cholesterol (28.00 mg/dL, 14.10%), LDL-c (22.00 mg/dL, 21.7%), TC/HDL-c ratio (-0.73, 20.7%) and LDL-c/HDL-c ratio (-0.55, 27.5%) in oligofructose-enriched inulin compared with the maltodextrin group (p<0.05). Changes in concentrations of triglycerides and high-density lipoprotein were not significant in oligofructose-enriched inulin compared to maltodextrin group.
Conclusion: Oligofructose-enriched inulin supplementation with improving in inflammtion and lipid profile help in management of type 2 diabetes and its complications.
Fahimeh Kazemi, Saleh Zahedi Asl,
Volume 18, Issue 6 (9-2015)
Abstract
Background: The physiological role of apelin, an adipokine secreted by adipose tissue , in insulin resistance and type 2 diabetes has been identified . The aim of this study was to determine t he correlation of plasma level s of apelin-13 with insulin resistance index (HOMA-IR) and plasma leptin of diabetic male rats after 8-week aerobic exercise .
Materials and Methods: Peresent study was an experimental study with animal model. Twenty eight diabetic male Wistar rats were divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by intraperitoneal injection of nicotinamide and streptozotocin. The trained diabetic rat ran 8-week on treadmill progressively. After the training period, plasma levels of glucose, insulin, leptin and apelin-13 were measured and HOMA-IR was calculated. One-way analysis of variance (ANOVA) and Pearson’s correlation were used for analyzing data. p<0.05 was considered to be statistically significant.
Results: A significant decrease in plasma levels of glucose, insulin and leptin and HOMA-IR in trained diabetic vs control diabetic rats, a significant increase in plasma levels of apelin in trained diabetic vs non-diabetic and control diabetic rats and a significant negative correlation of plasma levels of apelin with HOMA-IR and plasma leptin in trained diabetic rats was observed.
Conclusion: In present study, 8-week aerobic training by improvement of insulin sensitivity (decrease of HOMA-IR and plasma leptin) increased plasma levels of apelin-13 in diabetic male rats.
Mozhgan Aghamohammadi, Abdolhamid Habibi, Roohollah Ranjbar,
Volume 18, Issue 11 (2-2016)
Abstract
Background: Irisin, a recently identified myokine that seems had important role in hemostasis regulatation and improving insulin resistance. The effect of exercise training on serum irisin levels in type 2 diabates (T2D) is controversial. This study aims to investigate the effect of 6 weeks selective aerobic training on serum irisn levels and insulin resistance in women with T2D.
Materials and Methods: This research is a semi experimental study with pre-and post-test design. Research subjects were 20 women with T2D (mean age 47.4±5.6 years and BMI 29.92±3.42). Subjects were randomly divided into 2 groups: exercise group (n=12) and control group (n=8). Training protocol performed in 6 weeks (4 times a weeks, 40-65 min per session) and main training intencity and time were increased per week (50%-80% Hrmax). Main aerobic training was performed in 6 blocks, each block consisted of 32. Blood sample was collected before the and after end of training protocol.
Results: The results showed significant decrease in blood glucose, insulin and insulin resistance index and significant increase in serum irisin levels in exercise group compared with the control group (p≤0.05), but there is no significant correlation between serum irisin levels and insulin resistance.
Conclusion: It seems that aerobic training can have considerable impact on serum irisin levels, fasting blood glucos and insulin resistance index in women with T2D.
Mousa Khalafi, Fatemeh Shabkhiz, Karim Azali Alamdari, Afarin Bakhtiyari,
Volume 19, Issue 6 (9-2016)
Abstract
Background: Irisin is an exercise-induced myokine that is reduced with type 2 diabetes and improves insulin resistance via the browning of white adipose tissues. However, irisin response to two types of exercise in patients with type 2 diabetes is unknown.
Materials and Methods: In this study, 22 diabetic Wistar rats (Induced by high-fat diet and injections Stz) were randomly assigned to 3 groups: high intensity interval exercise (HIIT), low intensity continuous training (LICT) and control (C). Both HIIT and LICT groups trained on the treadmill 5 sessions per week for 8 weeks. Blood samples were taken 24 hours after the last training session and plasma irisin, insulin and glucose levels were measured. ANOVA and Tukey post hoc tests were used to analyze data and the level of significance has been considered at p≤0.05.
Results: Data analysis showed that plasma irisin levels in the HIIT group were significantly increased compared to the control group (p<0.05). However, there was no significant difference between other groups (p>0.05). Plasma glucose in both HIIT and LICT groups was significantly decreased compared to the control group (p<0.05). But plasma insulin levels and insulin resistance index were not different between groups (p>0.05).
Conclusion: The results of this study showed that exercise training can increase plasma irisin in rats with type 2 diabetes. However, these changes are partially dependent on the type of exercise training.
Abbas Saremi, Shahnaz Shahrjerdi, Atefe Kavyani,
Volume 19, Issue 9 (12-2016)
Abstract
Abstract
Background: Sirtuin-1 regulates important cellular processes, including apoptosis, cellular senescence, and metabolism. Therefore, sirtuin-1 may be a novel therapeutic target for type 2 diabetes. The aim of this study was to investigate the effect of 8 weeks aerobic training on sirtuin-1 level and cardiometabolic parameters in women with type 2 diabetes.
Materials and Methods: In this semi-experimental study with pretest – posttest design, twenty diabetic women (aged 43.92±5.2 y) were randomly assigned to aerobic training or non-exercising control groups. Aerobic training program was performed 50-60 min/d, 3d/wk, for 2 months. Serum levels of sirtuin-1, body composition and metabolic parameters were assessed before and after the training period. Data were analyzed by paired T test.
Results: Adiposity indices, total cholesterol, triglyceride, LDL- cholesterol,blood glucose and insulin resistance index were significantly reduced in the intervention group compared to the control (p<0.05). Also, sirtuin-1 level was increased in the intervention group compared to the control (p<0.05).
Conclusion: These findings show that aerobic exercise is associated with an improvement in siruin-1 levels and metabolic indices in women with type 2 diabetes.
Seyyed Payam Shariatpanahi, Danial Habibi, Mohammad Rafiei, Yazdan Ghandi, Mehdi Anvari,
Volume 20, Issue 12 (3-2018)
Abstract
Abstract
Background: Today, the high prevalence of diabetes and its complications are one of the most important public health issues worldwide. For this reason, finding relations between diabetes risk factors is very effective in preventing and reducing complications. For discovering these relations, the data mining methods can be used. By extracting association rules, which is one of the data mining techniques, we can discover the relations between a large numbers of variables in a disease.
Materials and Methods: The population of this study was 1046 patients with type 2 diabetes, whose data had recorded between 2011 and 2014 at the Special Clinic for Diabetes in Tehran's Imam Khomeini Hospital. After pre-processing step with SPSS19 software, 573 people entered the analysis phase. The FP-Growth algorithm was applied to the data set to discover the relations between heart attack and other risk factors using Rapid miner5 software. Relations, after extraction, were given to the doctor to confirm clinical validation.
Results: The obtained results of studying these 573 people (Including 292 (51%) women and 281 (49%) men, with age range 27 to 82 years) showed that the lack of blood pressure, creatinine and diastolic blood pressure at its normal level, despite higher systolic blood pressure level than normal, doesn't increase the probability of heart attack.
Conclusion: Using association rules is a good way of identifying relations between the risk factors of a disease. Also, it can provide new hypotheses to do epidemiological studies for researchers.
Saeed Esmaeili, Vazgen Minasian, Mohammad Bayat, Hadi Karami,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: Type 2 diabetes is one of the effective and inhibiting factors in controlling blood glucose and vascular disorders. The aim of this study was to investigate the changes in the gene expression of vascular endothelial growth factor and its type 1 receptor in cardiac tissue of type 2 diabetic rats following three different training methods.
Materials and Methods: In this study, 60 rats were randomly divided into 5 equal groups: healthy control, diabetic control, and diabetic groups with endurance, resistance, and combined exercise training. Type 2 diabetes mellitus was induced by intraperitoneal injection of streptozotocin and exercises were performed 5 sessions per week for 8 weeks. Evaluation of the levels of gene expression of vascular endothelial growth factor and its receptor 1 was performed by RT-qPCR.
Findings: The results showed a significant reduction in the expression of vascular endothelial growth factor in diabetic control, endurance training and resistance training groups, as well as a significant increase in expression of its receptor in diabetic control group and all training groups compared to healthy control group (p <0.001). Comparisons with the diabetic control group showed that in all training groups, the vascular endothelial growth factor gene expression increased, but in the its receptor 1 it was significantly decreased (p <0.001).
Conclusion: The findings suggest that different training exercises are effective in improving angiogenesis, but combined exercises have a certain superiority compared to other exercises.
Jalil Fathabadi, Maryam Haji Ghorbani Dolabi, Ali Akbar Arjmandnia, Saeid Sadeghi,
Volume 21, Issue 7 (2-2019)
Abstract
Background and Aim: Diabetes is a chronic disease that physiological, cognitive, behavioral, emotional and social factors play a role in preventing, risk and regulating it. This research aimed to predict blood glucose control by the use of irrational health beliefs and health locus of control in patients with type 2 diabetes.
Materials and Methods: The research population consisted of all type 2 diabetic patients referring to the two centers of Alzahra School of Charity Hospital and Diabetes Research Institute of Tehran University of Medical Sciences that 300 patients were chosen as sample by convenience sampling method. Data were gathered by using Multidimensional Health Locus of Control Scale (MHLC) and Irrational Health Belief Scale (IHBS) and analyzed by regression.
Ethical Considerations: This study was approved in Research Ethics Committee of biomedical researches in Tehran Universiry with the code IR.ut.Rec.1395.030.
Findings: There is a significant correlation between the predictive variables of irrational health beliefs (p <0.05), inner locus of control and others (p <0.05), and chance locus of control (p <0.01). The results also indicate that the health locus of control and Irrational beliefs predict significantly the changes in the amount of glucose (R=19, R2=0.037, F(4. 293)=2.80, p<0.05).
Conclusion: Based on the findings of this study, we can say that by identifying the health locus of control and irrational health beliefs, it is possible that blood glucose level can be predicted in patients with type 2 diabetes and reduced the consequences of diabetes in people with it. |
Esmail Asadpour, Saied Veisi,
Volume 21, Issue 7 (2-2019)
Abstract
Background and Aim: Marital and sexual problems of chronic patients, especially diabetes, that often are ignored, need special attention to proper treatment. The aim of this study was to investigate the effectiveness of acceptance and commitment therapy on marital satisfaction, sexual self-esteem and burnout martial among women with type 2 diabetes.
Materials and Methods: This study was a quasi-experimental research design with pretest-posttest and control group. The statistical population included women with type 2 diabetes in the city of Tehran. 30 patients were chosen as samples and randomly were divided into two groups of individuals as control and experimental. The experimental groups practiced the acceptance and commitment therapy 8 sessions and 60 minutes in each session. Then, post-test was performed for them. For data collecting, the marital satisfaction scale of Enrich (1993), sexual self-esteem scale of Doyle, Zeanah and Schwarz (1996) and burnout martial questionnaire of Pines (1993) were used. Data analysis was done by using multivariate analysis of multi covariance.
Ethical Considerations: This study with research ethics code IR.KHU.REC.1397.5 has been approved by research ethics committee at Kharazmi university of Tehran, Iran.
Findings: Results illustrated that after acceptance and commitment therapy, amounts of marital satisfaction and sexual self-esteem were significantly increased in experimental than control group (p<0.05). Also, acceptance and commitment therapy decreased burnout martial among women with type 2 diabetes significantly (p<0.05).
Conclusion: Acceptance and commitment therapy can be used as an effective psychological intervention on marital satisfaction, sexual self-esteem and burnout martial among women with type 2 diabetes.
Dr Minoo Motaghi, Dr Behzad Hamedani, Dr Parvaneh Khorasani, Mr Ahmad Bahrami,
Volume 26, Issue 1 (4-2023)
Abstract
Introduction: Today, the increasing prevalence of diabetes and its complications in the elderly is one of the most challenging problems in the health sector. One of the most important strategies for managing diabetes in the elderly is teaching self-care behaviors, which requires competent nurses in the field of diabetes education. The present study was conducted with the aim of determining the effect of empowering nurses on self-care and HbA1c control of elderly people with type 2 diabetes living in nursing homes.
Methods: This quasi-experimental study was conducted as a single group on 32 nurses and 30 elderly people with type 2 diabetes residing in nursing homes by convenience sampling. Nurses participated in a one-day empowerment workshop on type 2 diabetes. Data collection tools were a researcher-made questionnaire of workshop content to measure nurses' empowerment, Tobert and Glasgow self-care questionnaire and laboratory index HbA1c for the elderly. Data were analyzed using Spss version 20 at the 0.05 level. The present research has been registered with the ethics code IR.IAU.KHUISF.REC.1398.190 in the Ethics Committee of Islamic Azad University - Isfahan Branch (Khorasgan).
Results: Based on the findings, there was a significant difference between nurses' empowerment after the workshop compared to before (P=0.001). The mean scores of elderly before and three months after nurses' empowerment were significant in terms of self-care behaviors (P=0.000) and HbA1c index (P=0.000).
Conclusions: The results showed that the empowerment of nurses has desirable potential to change the outcomes of self-care in elderly people with type 2 diabetes resident in nursing homes, and by focusing on the approach of empowering nurses, positive steps can be taken in the management of diabetes and HbA1c of this group.
Amir Najafi, Mohammad Amin Momeni-Moghaddam, Dr Davoud Salarbashi, Narges Amini Beidokhti, Marziye Rahmani, Milad Khorasani,
Volume 27, Issue 3 (7-2024)
Abstract
Introduction: Type 2 diabetes is a non-communicable disease that imposes a significant financial burden on the healthcare system each year. Numerous studies have demonstrated the involvement of inflammatory factors in the initiation and progression of this condition. The primary goal of this study is to compare the polymorphism of the interleukin 1 receptor antagonist gene among individuals with type 2 diabetes and those in the control group.
Methods: Following approval from the Ethics Committee of Gonabad University of Medical Sciences, blood samples were collected from 100 participants at Bohlool Hospital in Gonabad. These individuals were categorized into two groups: cases (individuals with type 2 diabetes) and controls (healthy individuals). DNA extraction was carried out using the salting out method. To examine the polymorphism, the specific segment was initially amplified through PCR with designated primers and then identified via gel electrophoresis. The data were analyzed using subjected to the Chi-square test at a significance level below 5%.
Results: Findings from the polymorphism analysis revealed a notable contrast in the genotype 2/1 (P = 0.001) and 2/2 (P = 0.004) within the case group when compared to the healthy participants. Specifically, individuals with genotype 2/1 exhibited a heightened risk of developing type 2 diabetes by up to 15 times.
Conclusions: Within the examined population, the polymorphism of the interleukin 1 receptor antagonist gene substantially influenced the predisposition to type 2 diabetes, amplifying the likelihood of developing this ailment. Individuals harboring allele 2 are at an increased susceptibility to type 2 diabetes.
