Fatemeh Samimi, Maryam Baazm, Ebrahim Eftekhar, Farideh Jalali Mashayekh,
Volume 22, Issue 4 (9-2019)
Abstract
Background and Aim Oxidative stress is the main factor in the development and progression of diabetes and its related complications. There is growing evidence that antioxidants supplementation can improve oxidative stress induced in diabetes. The present investigation was conducted to study the effects of Coenzyme Q10 (CoQ10) on the Oxidative Stress Index (OSI) in diabetic rats.
Methods and Materials A total of 30 male rats were divided into five groups: saline, sesame oil (as a vehicle), CoQ10-treated (10 mg/kg/day), diabetic (induced with streptozotocin: 55 mg/kg), and CoQ10-treated diabetic (10 mg/kg/d). Then, we measured the Malondialdehyde (MDA), Total Oxidant Status (TOS), and Total Antioxidant Capacity (TAC) levels in the rats’ liver homogenate. Additionally, the OSI was calculated.
Ethical Considerations The Research Ethics Committee of Arak University of Medical Sciences approved this study (Code: IR.ARAKMU.REC.1397.119).
Results results showed a significant decrease in the level of liver MDA (P=0.022), TOS (P=0.03), and OSI (P=0.028) in the CoQ10-treated diabetic group compared to the diabetic rats. No significant change was observed in the total thiol group (P=0.25) and TAC (P=0.77) level in diabetic rats’ livers treated with CoQ10 compared to diabetic rats.
Mohammad Parastesh, Zahra Yousefvand, Behzad Aria, Majid Mardaniyan Ghahfarrokh, Jamileh Ahmadi,
Volume 28, Issue 3 (8-2025)
Abstract
Introduction: Cisplatin, a widely used chemotherapy agent, offers therapeutic benefits for cancer treatment but often leads to adverse effects on neurogenesis and oxidative stress. On the other hand, physical activity has been proposed as a potential strategy to counteract these side effects. Therefore, the aim of the present study was to investigate the effect of an endurance training period on oxidative stress markers in the brain tissue of rats induced with cisplatin.
Methods: In this study, 32 male rats with an average weight of 220 grams were divided into four groups: healthy control, cisplatin-injected control, endurance training, and cisplatin + endurance training. After 8 weeks of endurance training, the rats were dissected, and blood serum was separated to measure oxidant and antioxidant factors. Additionally, the brain was removed under sterile conditions for the examination of the desired markers. Data were analyzed using one-way ANOVA.
Results: The results showed that cisplatin significantly decreased MDA and significantly increased TAC and CAT in the cisplatin-receiving control group. On the other hand, 8 weeks of endurance training significantly decreased MDA and significantly increased TAC and CAT. Moreover, no significant change was observed in serum SOD levels. In brain tissue, MDA levels significantly increased, and TAC, CAT, and SOD levels significantly decreased in the cisplatin-receiving group. Conversely, 8 weeks of endurance training reduced MDA levels and increased TAC, CAT, and SOD levels.
Conclusions: Based on the findings of the present study, it appears that physical exercise has protective effects against cisplatin-induced oxidative stress in the brain, which may be attributed to its antioxidant capabilities
