Journal of Arak University of Medical Sciences

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Showing 2 results for Thyroid Nodule

Lack of Association between Nodular Throid Disease and rs1256049 Polymorphism of Estrogen Receptor Beta Gene in Women from Markazi Province

Ahmad Hamta, Maryam Yousefi, Masood Fazeli Mosleh Abadi, Afsaneh Talaei, Abdorrahim Sadeghi,
Volume 18, Issue 9 (12-2015)

Abstract

Background: Thyroid nodules are common. 4-7% of adults have a palpable nodule and up to 50-70% of nodules are detected in high-resolution sonography. Thyroid nodules in women are 4 times greater than men and the rate of thyroid cancer in women is 3:1 compared to men, and is the sixth most common cancer in women. Epidemiological findings and experimental evidences show that sex hormones, especially estrogen, may have effect on this gland and its neoplasm. The aim of this study was to investigate the association between rs1256049 polymorphism in the estrogen receptor beta gene with thyroid nodular disease.

Materials and Methods: In this case-control study, 146 Patients with nodular thyroid and 151 health individuals were referred to Amiralmomenin hospital of Arak were recruited in study. Diagnosis is based on by ultrasonography and was confirmed by an endocrinologist. Genomic DNA was extracted from EDTA treated whole blood .The genotypes were determined using tetra-amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) and analyzed by statistical methods.

Results: The frequency of CC, TC and TT genotypes in case group 136(93.2%), 10(6.8%) and 0(0%) and in the control group 139(92.1%), 12(7.9%) and 0(0%) were obtained respectively. No statistically significant association (p=0.72) was observed between nodular thyroid disease and rs1256049 polymorphism.

Conclusion: Our findings showed no significant association between rs1256049 polymorphism and nodular thyroid disease. For best deduction, it is recommended that this study be done in other populations.

The effects of metformin on thyroid nodules

Dr Afsaneh Talaei, Afsaneh Talaei,
Volume 28, Issue 2 (4-2025)

Abstract

Thyroid nodules are a common clinical finding. Recent attention has been drawn to the role of insulin resistance in their development. While several studies have explored the link between metformin and insulin resistance, fewer have assessed its effects on thyroid nodules.
This study examines the impact of metformin on thyroid nodule size and thyroid hormone levels.
The present study evaluate the effects of metformin on thyroid nodule size and thyroid hormones levels.

Methods:
A total of 240 euthyroid women with thyroid nodules were divided into four groups. Group 1 received 100 mcg of levothyroxine daily, Group 2 received metformin 500 mg twice daily, Group 3 received a combination of both drugs for three months, and Group 4 served as the control group with no treatment. Thyroid ultrasound was performed at baseline and after three months. Statistical analyses included the Kruskall–Wallis, Wilcoxon, and Chi-square tests, examined the differences of the size of thyroid nodules and the mean of thyroid hormones levels between groups, for each group and to compare the percentage of differences between the groups, respectively. Also P value less than 0.05 was considered meaningful.

Results:
Kruskall–Wallis test revealed no significant differences in thyroid hormone levels between the groups after treatment, except in the levothyroxine group. Wilcoxon test showed significant reductions in TSH and increases in T4 levels within the levothyroxine group. Additionally, thyroid nodule size significantly decreased in the levothyroxine and combination therapy groups, while metformin alone had no significant effect on the size of thyroid nodules.

Conclusion:
Metformin alone does not appear to reduce thyroid nodule size. Future studies with larger sample sizes and extended durations are necessary to validate these findings and further explore metformin’s role in thyroid nodule management.

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