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Introduction: Dysmenorrhea is one of the most prevalent complaints of women which is due to Prostaglandin release and is treated by chemical drugs. Today regarding side effects of these drugs, scientists are increasingly moving toward using herbal drugs. This study is planned to comparison the effects of Thymus Vulgaris and Mefenamic acid on primary dysmenorrhea.
Materials and Methods: This is a clinical trial study. Target population was women suffering from primary dysmenorrhea and study population was women reffering to marriage consulting center. Based on α=0/5, β=0/20, sample size was calculated 214 which were divided into two groups randomly. Samples were asked to determine their pain severity before using the drug, by a visual scale (0-10cm). In the study group each sample cosumed 15 grams Thyme leaf brewed in a glass of water and in control group samples used 250mg Mefenamic acid capsules. Then pain severity was determined again 1, 2 and 3 hours after using drugs. Data was analysed by mean and standard deviation indexes and K-S, man-whitney and chi-square tests. Helsinki declaration was regarded at all stages of the research.
Results: Pain severity mean, before using the two drugs had no significant difference between groups. In each group, pain severity was significantly decreased before and after using the drug (p=0.05). But the rate of decreasing pain between the two groups showed no significant difference.
Conclusion: Regarding results, it seems both Mefenamic acid and Thymus Vulgaris decrease pain at the same level which seems to be due to Thyme,s antiprostaglandin and antispasmodic effects.

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Introduction: The emergence of antifungal resistance in Candida albicans diseases poses a threat to global public health. New treatments are needed to target C. albicans and its ability to produce hyphae. The aim of this study was to investigate the potential synergistic effects and antifungal properties of Thymus vulgaris and Trigonella foenum-graecum extracts alone and in combination on C. albicans.
Methods: In this experimental study, extracts of Thymus vulgaris and Trigonella foenum-graecum were prepared using hot water (60 ^°C) and Soxhlet extraction with methanol (10%). Yeast susceptibility testing was performed according to the Clinical and Laboratory Standards Institute disk diffusion and broth microdilution guidelines. The hyphal model was created in the presence of alcoholic extracts of Thymus vulgaris and Trigonella foenum-graecum alone and in combination. Crystal violet staining, microscopic observation and gene expression analysis were used to evaluate the inhibition of hyphal growth.
Results: The results showed that 90% of the C. albicans isolates were resistant to fluconazole. Aqueous and alcoholic extracts of Thymus vulgaris in combination with Trigonella foenum-graecum showed synergistic, partially synergistic and additive effects. Alcoholic extracts of Thymus vulgaris with Trigonella foenum-graecum alone and in combination have anti-hyphae activity by reducing the percentage of hyphae, reducing the number of planktonic cells and the transition of planktonic cells to hyphae, and down-regulating the Secreted Aspartyl Proteinase 1 (SAP1) gene.
Conclusions: Taken together, these results indicate that extracts of Thymus vulgaris alone and in combination with Trigonella foenum-graecum may offer a potent alternative strategy to combat resistant C. albicans infections and their ability to reduce hyphae formation. Additionally, the SAP1 gene could be a likely target in the synergistic interaction of alcoholic extracts of Thymus vulgaris in combination with Trigonella foenum-graecum against the C. albicans hyphae model.