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Background and aim: Schizophrenia is a chronic illness, and one of the major health problems in the world. So the select of different treatment methods that is appropriate for community culture is very important and necessary issue. The purpose of this study was to investigate the effect of religious training (prayer) on quality of life of schizophrenic inpatients. Materials and methods: 62 schizophrenic inpatients were assigned randomly to two groups: experimental and control. Data were collected via Schizophrenia Quality of Life Scale (SQLS). After two months religious training (prayer) for experimental group (three times a week), all of the subjects were assessed again. Findings: The findings showed that, before intervention there was no significant difference between two groups (t=-1/78, p=0/08). After intervention (religious training), there was significant difference in experimental group (t=2/09, p=0/04). Despite the difference in experimental group, there was no significant difference in control group (t= 1/50, p= 0/14). Conclusion: This study showed that, religious and spiritual training can be increase the satisfaction of quality of life schizophrenic patients.