Journal of Arak University of Medical Sciences

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An investigation on the efficacy of hemodialysis in Vali-e-Asr hospital of Arak city based on urea kinetic model in year 2003

Soleiman Zand, Hadi Hasan-Khani, Parvin Soltani,
Volume 10, Issue 1 (3-2007)

Abstract

Introduction: End stage renal disease (ESRD) is a major health problem and each year the number of patients is increasing. If the disease becomes irreversible, patients must always be hemodialyzed. Since mortality rate will increase due to inadequate dialysis, determining the efficacy of hemodialysis and improving its quality is very important. The main goal of this research is investigating the efficiency of hemodialysis. Materials and Methods: This is a cross-sectional analytical study which was conducted on 103 people who were under dialysis treatment in the Vali-e-Asr hospital of Arak in year 2003. Weight, blood pressure (before and after dialyze), time of dialysis, BUN and Cr before dialysis and 5 minutes after turning of the pump and before the second dialysis were measured. Data was analyzed by T test and Pearson correlation. Results: The mean of KT/V was 0.58 ± 0.1 normal protein catabolic rate (nPCR), 0.36 ± 0.11 g/kg per day and time average concentration of urea (TAC), 43.3 ± 14 mg/d which had a significant difference with standard measures (p<0.05). KT/V was 0.49 ± 0.18 and 0.47 ± 0.10 for men and women respectively which was significantly different (p<0.03). There was a positive and linear relationship between education level and TAC, KT/V and number of dialysis per week. Conclusion: Regarding the low efficiency of hemodialysis in 80% of patients and lower levels of hemodialysis efficacy indicators in comparison to standard measures, periodic assessment and also investigating the reasons of low efficacy of hemodialysis is recommended.

The Association Between GSTP1 A/G Polymorphism and Oxidative Stress with End Stage Renal Disease (ESRD) in Kermanshah

Hamid Nomani, Ali Aidy, Lida Hagh Nazari, Dariush Reissi,
Volume 16, Issue 9 (12-2013)

Abstract

Background: End stage renal disease or ESRD is a progressive and irreversible deterioration in renal function in which the body’s ability to maintain metabolic and fluid and electrolyte balance fails. Glutathione s-transfrase P1 is member of multigenic family which have essential role in cells as an antioxidant. In this study we investigated the polymorphism of GSTP1 genotypes and oxidative stress in ESRD patients and compare with control subjects to determine the possible relation between polymorphism of this enzyme and ESRD.

Materials and Methods: We select 136 ESRD patients and 137 control cases (without kidney disease). GST P1 polymorphism were determined with PCR-RFLP. Level of MDA was measured by HPLC apparatus.

Results: Genotypes distribution of GSTP1 A/G polymorphism to AA, AG and GG genotypes in control group were 70(51.1%), 56(40.9%) and 11(8%) and In diabetic group 74(55.6%), 50(37.6%) and 9(6.8%), respectively (p=0.744). MDA levels in ESRD patients was higher than control group (p<0.001).

Conclusion: GSTP1 A/G polymorphism between two groups and each groups was not statistically significant with ESRD, probably this enzyme has a protective role in the risk of ESRD.

Psychological Challenges of Patients After of With Renal Disease After Transplantation: A Qualitative Study

Homa Yousefie, Anahita Khodabakhshi-Koolaee, Mohammad Reza Falsafinejad,
Volume 22, Issue 6 (1-2020)

Abstract

Background and Aim: Currently, the prevalence of chronic kidney disease has increased for a variety of reasons. Renal diseases, followed by dialysis and kidney transplantation, can greatly affect the People's physical and mental health. Since most of previous studies have examined the physical and often preoperative problems of kidney transplant patients and many of them have used quantitative methods, the present study aimed to investigate the psychological challenges of renal disease patients after Kidney transplantation.
Methods & Materials: The study population consisted of kidney transplant patients referred to the Nephrology Clinic of Labafinejad Hospitalin Tehran, Iran in 2019 aged 35-50 years and 1-5 years had passed since their transplantation. A semi-structured in-depth interview was done for collecting information. A purposive sampling and continued until data saturation and until no themes were available. In the end, 15 patients were interviewed. Data analysis was performed by Colaizzi’s method.
Ethical Considerations: This study with a code of IR.IAU.SRE.1398.022 was approved by the Research Ethics Committee at Islamic Azad University, Science and Research Branch in Tehran, Iran.
Results: The primary themes were divided in to 3 main themes including: Concerns and psychologically disturbing feelings, emotional and spiritual support of the family, and uncertainty of receiving specialized, financial and welfare support.
Conclusion: Patients with kidney disease after transplantation surgery have psychological challenges in addition to physical problems that are of great importance to mental health professionals. Studying these challenges can provide a deeper understanding of their psychological problems and adaptation after surgery.

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