Journal of Arak University of Medical Sciences

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Showing 2 results for Renal Function

Effect of the Alcoholic Extract of Portulaca Oleracea on Renal Ischemia/Reperfusion Injury in Rats

Majid Askaripour, Syed Reza Fatemi Tabatabaei, Hossein Najafzadehvarzi, Foruzan Hosseini,
Volume 18, Issue 11 (2-2016)

Abstract

Background: Renal injury following ischemia - reperfusion (I/R) is still an unavoidable problem in many remedial and medical situations. Portulaca oleracea (PO) has been known for its anti-oxidative effects. Then, the present study aimed to investigate the effect of ethanolic extract of PO (EEPO) on the renal function and antioxidant status after induction of I/R injury in the rat kidney.

Materials and Methods: A total of 30 rats (Wistar) were divided into five groups (n = 6 each). Sham group: underwent laparotomy without I/R, EEPO group: EEPO administered 300 mg/kg then was operated like sham, I/R group: was underwent renal ischemia/reperfusion only, EEPO150+ I/R and AEPO300+ I/R groups: were administered PO 150 and 300 mg/kg then underwent I/R operation. PO extract was administered for 5 days in the relevant groups by gavage. Serum urea and creatinine (Scr), the level of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and total antioxidant activity (TAA) were determined. Data were analyzed by ANOVA and post hoc LSD test. P values of 0.05 or less were considered statistically significant.

Results: Induction of I/R and pretreatment with PO extract, increased the level of superoxide dismutase (SOD) in comparison with sham group (p<0.05, p<0.001). There were no significant differences in the levels of MDA, GSH and TAA among different groups. On the other hand, the Scr and serum urea of the I/R and treated groups were elevated compared to the sham group (p<0.001).

Conclusion: Ethanolic extract of PO did not strongly affect the renal antioxidant status and could not prevent the renal injury following I/R.

Investigating the Relationship between Serum Adropin Levels and Markers of Renal Function in Active and Inactive Young People

Seyed Sarmad Zahmatkeshan, Hamid Rajabi,
Volume 28, Issue 4 (10-2025)

Abstract

Introduction: The aim of this study was to investigate the relationship between serum adropin levels and markers of renal function in active and inactive young people.
Methods: The present research was conducted using a correlational method.Fifty young men and women with an average age of 28.22 ± 2.27 years, height 170 ± 8 cm, and body mass index 24.72 ± 4.88 kg/m² participated in the present study. Subjects were divided into active and inactive groups based on Beck's questionnaire, and 3 cc of blood was taken from their brachial vein to measure levels of adropin, urea, uric acid, creatinine, blood urea nitrogen (BUN), albumin, and total serum protein. The normality of the data was determined through the Kolmogorov-Smirnov test, and the independent t-test was used to compare the mean of the data, and the Pearson correlation coefficient was used to determine the correlation.
Results: Although a strong, positive (r = 0.78 +) and significant (p < 0.05) correlation was observed between adropin and physical activity, the renal function markers did not show a significant difference between the two active and inactive groups. No significant correlation was observed between renal function markers and adropin levels and between renal function markers and physical activity.
Conclusions: With increasing physical activity, the amount of adropin increases, but this increase does not change the levels of renal function markers in healthy people. Therefore, it seems that there is no relationship between adropin levels and renal function markers in healthy young people.

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