Showing 5 results for Rabbit
Saeed Babaei, Saeed Changizi Ashtiani, Hamid Gerami, Ali Reza Jamshidifard , Mohammad Rafiee,
Volume 6, Issue 3 (10-2003)
Abstract
Introduction: At present, bone graft is unavoidable. In fact although among the all probable bone grafts, the autograft is the best choice, but because of some situations like two coincidence surgery upon one individual, size limitation of autografts (its impossible to get a big piece of graft from patient) increasing the bloodshed contingency, infection etc, made specialist to think about the possible substitution the allograft.
Materials and Methods: Seventeen Newzealandian rabbits were divided into four groups. The graft generator group consisted of one rabbit which was genetically different from other groups. The sham group composed of three rabbits which round autografts about 4 mm in diameter from their tibia were exchanged between rights and left tibias. These grafts were not deantigenized and a 4 mm vacant hole was created to see if it will repair spontaneously within three months. The control group consisted of three rabbits received a round 4 mm tibial autografts which double deantigenization process were done over them. The test group composed of 10 rabbits, received corticocancellous (intramembranous) allografts in left tibia and corticocancellous (endocondral). Allograft in right tibia all grafts were bearing the double deantigenization process.
Results: The rate of prosperity for CCl grafts was 80% and for CCE grafts was 60%.In sham group, healing process was extremely fast (in eight weeks).
In control group, healing process was done slower until six weeks but after 12 weeks it was compensated. The vacant holes were not repaired even after three months. Statistically, there was a meaningless difference between the rates of prosperity in both groups of grafts.
Conclusion: According to statistical assays, although the prosperous numbers of CCl were more than CCE grafts but this difference was meaningless. In the basis of histological assessments if the velocity of healing process is important, the CCI grafts are recommended
Mohammad Ali Shariatzade, Naser Mahdavi, Malak Soleimani Mehranjani, Hamidreza Momeni,
Volume 11, Issue 3 (9-2008)
Abstract
Background: One of the best examples of epimorphic regeneration in the mammals is the formation of new tissues formed from blastema in holes punched in the ears of rabbits. The aim of this research is to investigate speed and percentage of regeneration in different geometrical shaped holes and different regions of rabbit's ear. Methods and Materials: In this experimental research different region of rabbit's ear (proximal, medial and distal) were punched as different geometrical shaped holes (circlc, quadrangle and triangle) with the same area (50 mm2) Ubyg a puncher which designed for this purpose. The regeneration of wounds was evaluated and the percentage of regeneration was calculated. After punching, each 3 days (36-40 days). Results: Results showed speed and percentage of regeneration in circular holes was significantly (P<0.05) more than quadrangular and triangular holes. In addition, regeneration speed of holes located in proximal regions of ear, was more than peripheral holes. Conclusion: Wound regeneration in rabbit's ear is related to the geometrical shape of holes. Speed and the percentage of regeneration in circular shapes is more than angular shapes.
Jina Khayatzadeh, Hossein Rafiei, Majid Farhoodi,
Volume 12, Issue 3 (10-2009)
Abstract
Abstract Background: Cartilaginous and movement diseases are the most prevalent problem in human. Various vitamins like A and C increase the process of regeneration and wound healing. In this research, the Alfalfa plant with scientific name Medicago sativa, that contains a lot amount of A, C, E and K vitamins, was used and effect of its extract on regeneration of pinna rabbit cartilage was studied. Materials and Methods: In this experimental laboratory study, 6 New Zealand male rabbits with 2.5-3 kg weight have been selected. After shaving hairs on ears with depilation cream, the ear were anesthetized by lidocaine 10% and 4 holes were punched with 4 mm diameter in medial situation of each ear. Test ears by extract of Medicago sativa and control ear were treated by normal saline every day. Holes era and the distance of two edges of cartilage were measured in various days of healing. Also, tissue sampling for microscopic observation by H&E color (day 0-50) was done. Results: Regeneration and healing of the treated holes with extract of Medicago sativa was faster than the control holes (p<0/004). Also, thickness of cartilage and cell density of chondrocytes and fibroblasts in the newly formed connective tissues in test were more than control. Conclusion: The extract of Medicago sativa because of A, C vitamins containing, probably increased the wound healing and regeneration of the rabbit ear cartilage and suggest the pharmacological usages.
Ali Khavanin, Mohsen Soleimani, Mehdi Akbari, Ramazan Mirzaie, Masoud Motallebi, Hasan Asiliyan, Ardalan Soleimanian,
Volume 14, Issue 2 (5-2011)
Abstract
Background: Trauma noise is one of the major physical pollutants in modern societies. Sound conditioning, on the other hand, is known as one of the mechanisms for protecting the hearing system.
Materials and Methods: In this experimental study, 15 three month-old male white New Zealand rabbits were divided into three groups. The equipments used in this study included a sound generator, a loudspeaker, an exposure box, a sound level meter, and a distortion product otoacoustic emission (DPOAE) device. The rabbits were assigned to trauma noise exposure, conditioning noise exposure, and control groups. The conditioning and traumatic sound levels were respectively 80 and 105dB within the 500-3000 Hz frequency.
Results: Conditioning noise at the level of 80 in combination with trauma noise enhanced the rabbits hearing system tolerance up to 13-17 dB so that in all frequencies there were significant differences between the trauma noise exposure group and the sound conditioning and trauma noise conditioning group (P<0.05).
Conclusion: Sound conditioning can act as an effective factor in protecting the hearing system against trauma noise.
Abbas Zaree Mirakabadi, Abdolhamid Angaji, Adele Hooshmandi,
Volume 17, Issue 2 (5-2014)
Abstract
Background: One of the acute effects of snakebite is injury to vital organs including kidneys. This study examines the effects of snake (Najanajaoxiana) venom on renal function.
Materials and Methods: In this experimental study, six male Dutch rabbits with average weight of 1.5± 0.3 kg were selected. Before injection of the venom, blood samples were collected for serum analysis and then the snake (Najanajaoxiana) venom (140µg/kg) was injected intramuscularly. Following venom injection, blood sampling from each rabbit was carried out at hours 1, 3, and 24. All serum samples were separated within two hours and the amounts of creatinine, urea, albumin, and glucose were determined by quantitative detection kits. Statistical analyses were carried out by SPSS software version 21. Obtained information was compared by one-way ANOVA and F and Tukey tests. p value<0.05 was considered significant.
Results: Following venom injection at hours 1, 3, and 24, some serum parameters showed slight changes which were not statistically significant. However, glucose showed a significant increase (71%) at hour 1 (p<0.05). Following venom injection, this returned to normal at hour 24.
Conclusion: Based on the results obtained in the present study, it seems that the Najanajaoxiana venom, unlike the viper species, have no severe effects on the kidney.
