Introduction: Adverse effects of Coronavirus on somatic and mental health is undeniable .nurses staff are exposed to risk of somatic and psychological effects because of continuous working time. The aim of this study was to investigate the effectiveness of training coping strategies with stress on distress tolerance and psychological empowerment of corona nurses in Khoy hospitals.
Methods: This research was applied in terms of purpose and quasi-experimental in terms of research method with pre-test – post-test design with control group And from the statistical population that included all nurses in the corona ward of Khoy hospitals in  2021 , 30 people were selected as the available sample. The subjects were randomly assigned into two groups (15 individuals in experimental group and 15 individuals in control group).In order to collect data, the Distress Tolerance Questionnaire and the Psychological Empowerment Questionnaire were used. The experimental group subjects participated in eight 90-minute sessions of training coping strategies with stress. Multivariate analysis of covariance was used to test the hypotheses. This study was approved by the Ethics Committee of Islamic Azad University of Tabriz (Code: REC.1400.135).
Results: The results showed that training coping strategies has increased distress tolerance and psychological empowerment in the post-test phase (P < 0.01).
Conclusions: According to the findings of the present study, it can be concluded that teaching coping strategies can be used as an effective method to improve stress tolerance and psychological empowerment of coronary nurses.