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Introduction: Some articles have suggested an increase in the prevalence of oral candidiasis in patients with psoriasis, as well as the potential for exacerbation or chronicity of psoriasis. Therefore, the prevalence of oral candidiasis in patients with psoriasis and its comparison with healthy individuals has been considered.
method: In this cross-sectional study, 43 people with psoriasis and 43 seemingly healthy individuals referred to dermatology clinics affiliated with Isfahan University of Medical Sciences were randomly selected and examined for the presence or absence of Candida albicans in the oral mucosa by direct lam and culture. Were placed.
Results: According to the results of this analytical study, 44.2% of patients with psoriasis with Candida albicans were infected with oral cavity, which was 25.6% for healthy individuals, and this difference was significant (p=0.05). There was also a significant relationship between the severity of psoriasis and the prevalence of oral Candida albicans (p=0.05).
Conclusion: The study found that candida yeast was more common in patients with psoriasis than in healthy people. According to the results of this study, it is recommended that all patients with psoriasis be examined for the presence of Candida albicans in the mouth and, if the test is positive, be treated with antifungal drugs.

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Background: Psoriasis is a common chronic skin disease which usually appears as white and silvery spots on the skin. The purpose of this study is to investigate the effect of berberine on patients with psoriasis. Materials and Methods: This double-blind clinical trial was conducted on 60 psoriasis patients who referred to Imam Khomeini Hospital, Ahvaz, between July and December 2011. The patients were randomly divided into two equal groups that applied berberine and placebo to the treatment of their lesions twice a day. Lesions severity rate in the patients was assessed 7 times using a Psoriasis Area Severity Index (PASI). Data were analyzed by ANOVA with repeated measurements and Chi-square using SPSS software. Results: After 6 months, severity of lesions showed a significant decrease in the group receiving the berberine cream compared with the placebo group so that the mean PASI score of the group receiving berberine decreased from 3.99 to 2.11 while in the placebo group this decreased from 3.98 to 3.71. Mean difference in PASI score was not significant before receiving the treatment till the third month in berberine and placebo groups, but in the fourth to sixth months it was statistically significant (p=0.013). Conclusion: Berberine cream was more effective than the placebo in reduction of skin lesions of psoriasis patients. Therefore, it is recommended that plant-based drugs, like berberine, be used more besides the main medications of patients.