Showing 7 results for Prognosis
Khadijeh Arjmandi Rafsanjani, Ali Chehrei, Majid Chalian, Shayan Shojaei, Ali Fahimi, Pedram Golnary,
Volume 5, Issue 3 (10-2002)
Abstract
Introduction: Wilms' tumor is the most common malignant and primary renal tumor in children. Studies, which have been done in some countries, have introduced numerous factors such as age of incidence, stage, lymphadenopathy, histopathology and etc. Effective in the survival rate of this tumor according to the importance of this tumor in children, we decided to perform a study about the survival rate of Wilms' tumor and the effective factors on it.
Materials and methods: This is an analytic study on 128 patients affected with Wilms' tumor whom referred to the oncology ward of Hazrat-e-Ali Asghar Hospital between 1977 and 2001. In addition to the current status of the patients, demographic characteristics, signs and symptoms, laboratory studies at the time of diagnosis and the stage of the disease were recorded and ultimately survival analysis was performed using the Kaplan-Meier procedure and life table. Cox Regression was used to determine the effective factors.
Results: The mean survival rate was 82.99 months. The number of patients was equal in both genders (64 patients in each gender) and the survival average did not have any significant statistical relationship with gender (power=%92.4). Most of the tumors were in stage 3 at the time of diagnosis. The survival of the patients was reducing significantly with the progression of the stage of tumor (P=0.002). The existence of metastasis (P=0.000, odds ratio=0.207), splenomegaly (P=0.018, odds ratio=0.336), and recurrent (P=0.037, odds ratio=0.184), were significantly reducing the survival of the patient. To determine the severity of effective factors on the survival rate of the patients Cox Regression Method was used in which, absence of metastasis and positive blood group were from well-prognosis predictive factors in these patients.
Conclusion: 5-year survival rate of the patients was 63.28% in this study. Which was lower in comparison with the results of other studies in other countries. This can be the result of delay in consulting with medical centers, the diagnosis method and or the Referral State of this center. Recent studies have shown that age and tumor size has minimal values in the prognosis of the patients due to improvement in the quality of treatment and our study support this idea. Genetic factors will probably be used in determining the survival of these patients and also in thcir treatment.
Fardin Faraji, Afson Talaie Zanjani, Babak Eshrati, Shadi Pirasteh,
Volume 11, Issue 4 (12-2008)
Abstract
Background: Stroke is one of the important causes of death. However the prognostic factors are not clearly defined. There are many evidences which show the role of inflammatory factors during the progression of stroke but the relation of CRP and stroke is still vague. This study was designed to determine the relation between CPR Level and WBS with severity of stroke (according to CNSS score) and volume of infarct in stroke patients.
Methods and Materials : This is a cross sectional study performed during the winter and spring of 2007 on 49 patients with stroke hospitalized in Vali-e-Asr hospital of Arak.Clinical examination was done by using CNSS scoring. The CRP and WBC were measured in the first 72 hour of onset of the disease. The CT scanning together with infarct volume estimation was performed at the same time.
Results : There was no correlation between the volume of infarct with CRP serum level (r=-0.14, p=0.39 ) and WBC (r=-0.17, p=0.92 . Also there was no correlation between CNSS score with CRP level (r=-0.04, p=0.81) and WBC (r=-0.124, p=0.40) too, but there was a significant correlation between CNSS score and stroke volum in brain CT scan (r=-0.43, p=0.006 ).
Conclusion: According to data in this study there was no correlation between serum acute phase reactant, the volume and severity of infarction.
Valiollah Khadir Sharabiany, Saeed Oraii,
Volume 12, Issue 3 (10-2009)
Abstract
Abstract Background: Current electrocardiography (ECG) criteria are insensitive for the detection of posterior acute myocardial infarction (AMI) and most of these cases remain undiagnosed. The purpose of this study has been evaluated of prevalence and clinical value of ST-segment in posterior electrocardiography leads during acute myocardial infarction. Materials and Methods: In cross- sectional analytic study, posterior ECG leads (V7, V8 and V9) as well as standard 12 leads in 210 consecutive patients with acute myocardial infarction admitted to CCU wards of Shahid Rijaie hospital. Reinforcing, continuous arrhythmia, hypotension, cardiologic shock, marked heart failure and/or acute pulmonary edema were considered. Related parameters to basic characteristics and next process of patients in two groups with/ without ST- segment elevation in posterior ECG lead were compared. Results: There were 153 patients with ST-segment elevation 1 mm in 2 contiguous leads. 12.4% patients had STE1 mm in 2 posterior leads, either as an isolated finding (4.6%) or in association with STE at inferior or lateral sites (7.8%). The standard 12-lead electrocardiogram was normal in two patients and 5 other patients were admitted with the diagnosis of non-Q infarctions. Tall R waves in V1/V2 developed in 5 cases. In-hospital complications were significantly more frequent among patients with STE in posterior leads (47.4% vs. 20.9% respectively, P=0.01). Conclusion: STE in posterior electrocardiography leads is not uncommon during acute myocardial infarction and may portend a worse in-hospital course.
Shabanali Alizadeh, Kamran Moshfeghi, Mssoumeh Kalantari, Khadijeh Ebrahimi,
Volume 12, Issue 4 (2-2010)
Abstract
Background: The existence of estrogen and progesterone receptors, p53, human epidermal receptor-2(HER-2) and cathepsin-D are among the prognostic markers for breast cancer. In this study, we investigated the relationship between these factors and lymph-node involvement. Materials and Methods: In this case-control analytic study, 105 patients with breast cancer were investigated. After detecting breast mass, surgical biopsy was done and the status of the estrogen and progesterone receptors, p53, HER-2, and cathepsin-D were studied. Collected data were registered in a checklist and were subjected to analysis. Results: There was no relationship between lymph-node involvement and estrogen and progesterone receptors, p53, cathepsin-D and HER-2. Conclusion: In order to get more precise results about hormonal receptors, p53, HER-2 and cathespin-D, a similar research with a larger sample size over a longer period of time is needed.
Amir Abdollah Zangivand, Mahsa Ghasemi,
Volume 17, Issue 6 (9-2014)
Abstract
Background: Inflammation has an important role in the pathogenesis of atherosclerosis. The aim of this study was to evaluate the role of WBC (White Blood Cell) count and incidence of morbidity and mortality in patients with ACS.
Materials and Methods: This prospective study was carried out on 101 patients with ACS who admitted in Bu-ali Sina hospital. All patients were stratified according to WBC categories in to 3 groups, (WBC 1 :<7000 mm3, WBC 2:7000 -10000 mm3, WBC 3:> 10000 mm3). Demographic and laboratory data such as acute reactive protein, cardiac biomarker and etc. were recorded. Adverse cardiac events and mortality were recorded to a phone or in person for six months of follow up period. The collected data were analyzed using SPSS software (Statistical Package for Social Sciences, version 17.0). The Fisher´s exact chi-square test and the student t-test were applied. P-values less than 0.05 were considered significant.
Results: In our study, 5 patients (31.25%) in third group had recurrent non fatal cardiac event and the same percent (31.25%) were died after 6 months follow up. Multivariate analysis showed WBC count >10000 mm3 was strongest predictor of outcome in our patients.
Conclusion: WBC count can be considered one of the strong independent predictor of mortality and cardiac event in patients with ACS.
Sara Karimi Moghadam, Roohollah Dorostkar, Saeed Hesami Takallou,
Volume 20, Issue 11 (2-2018)
Abstract
Abstract
Background: Breast cancer is the most common cancer in Iran and breast cancer is the fifth leading cause of death among women. Diagnosis of breast cancer in early stages could increase the lifetime of more than 90% of patients. Human endogenous retroviruses are as heterochromatic parts of the genome, lack any expression. But in several categories of human cancers, including breast cancer, there is a significant increase in the level of HERV-Kenv mRNA.
Materials and Methods: In this case-control study, blood samples were collected from 40 breast cancer patients admitted in Baqiyatallah Hospital and 20 healthy individuals to study the increased expression of HERV-Kenv mRNA using specific primers and were tested by RT-PCR.
Results: Investigations on the patient and control groups showed that increased expression of mRNA was positive in 60% of patients with breast cancer and negative in all healthy subjects.
Conclusion: The results of this study showed that expression of mRNA HERV Kenv in breast cancer was increased. Since enhancement of mRNA HERV-Kenv in the blood of breast cancer patients occurs in of disease, these retroelements could be used as a diagnostic biomarker
Andia Seyedi Moghaddam, Mahdieh Salimi, Najmeh Ranji, Hossein Mozdarani,
Volume 25, Issue 1 (3-2022)
Abstract
Background and Aim MicroRNAs (miRNAs) are a class of small non-coding RNAs (17-25 nucleotides) that have been studied in many diseases. miRNAs studies in different cancers have shown that miRNAs may be considered oncogene or tumor suppressor. So far, many studies have shown that miR-17-5p and miR-93-5p are important regulatory molecules in some biological processes, such as cell proliferation, associated with cancer formation. This study aimed to investigate and compare the tissue and plasma expression levels of miR-17-5p and miR-93-5p in patients with ductal carcinoma breast cancer with the normal control group.
Methods & Materials The total RNA (including miRNA) was extracted from breast and plasma tissue samples of cancerous and normal samples. The RNA concentration and purity were confirmed using optical absorbance measurements. cDNA was synthesized, and the expression levels of miR-17-5p and miR-93-5p were assessed semi-quantitatively by SYBR Green-based real-time RT-PCR assay in plasma and breast tissues of ductal carcinoma breast cancer compared with the control normal samples with SNORD47 as internal normalizer. Data were statistically evaluated using GraphPad Prism 8.0.2.
Ethical Considerations This study was approved by the Ethics Committee of the institute (IRAN 52d/4922, 6.10.2016). All study individuals signed a consent form to use their clinical samples and personal data under the physician’s supervision.
Results The expression level of miR-17-5p showed significantly higher expression in tissues and plasma of the cancer group compared with the control group (P<0.0001). It was also significantly associated with tumor stage and lymph node, and ER (estrogen receptor) and PR (progesterone receptor) status (P<0.0001). While decreased expression of miR-93-5p in plasma and tumor tissues was shown to be significantly associated with tumor stage and lymph node involvement (P<0.0001).
Conclusion The data revealed that high expression of miR-17-5p and low expression of miR-93-5p in both plasma and breast tumor might be associated with poor prognosis in breast cancer. However, miR-17-5p, due to the greater change in expression and ease of plasma detection, may serve as a possible non-invasive biomarker for breast cancer’s poor prognosis. Further follow-up studies are required to confirm this finding.
