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Introduction: Cisplatin is a drug widely used as an antineoplastic drug for treatment of malignant tumors. But because of its side effects on the different systems especially kidney (nephrotoxic), the use of this drug is very limited. Clinical as well as, laboratory animal studies have supported this observations. In this research study we have used stereological technique (3-D) for finding the changes, due to nephrotoxic effect of this drug, in the number of glomeruli in kidney (numerical density and total number).
Materials and Methods: For experimental, 30 rats were separated by random sampling in to 3 groups of 10 animals cache. The first group received acute dose (7.5 mg/kg) of the drug (cisplatin) in serum physiology (experimental group). The second group received equivalent placebo dose in serum physiology through peritoneum (control). The third group received chronic dose (1.25 mg/kg) for 5 days, in serum physiology. All the 30 animals, after 96 hours, were anesthetized, dissected and their right kidneys were removed and placed in fixative (10% formalin). Whole kidney specimens were processed for stereology by special method of sectioning for physical disector and glomeruli number were counted.
Results: Number of glumeroli and numerical density was estimated for experimental groups (control, acute and chronic) was 31707, 30415 and 30802 as well 162, 119, and 140 respectively.
Conclusion: Stereological methods could be very useful for investigation of chemical drug effects in organs with good validity.

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Introduction: Among the risk factors for coronary artery disease, less attention has been paid to physical activity, especially in children and adolescents. Various studies have shown that their level of physical activity is lower than the standard for maintaining lower health. In this study, the pattern of physical activity of children and adolescents in the central regions of Iran is examined.
Method: In this descriptive study, which is part of the first phase of the Isfahan Healthy Heart Project and was conducted in 2002, awareness of the attitude and performance of 4,000 urban and rural children and adolescents in preschool to high school in Isfahan (Isfahan, Najafabad) and Markazi (Arak city) and the parents of these students and 500 teachers and school officials have been examined about physical activity and the duration of watching TV through a questionnaire. Sampling was selected in the form of a random cluster and in proportion to the urban and rural population living in the two provinces. Data were analyzed with SPSS software and p<0.05 were considered significant.
Results: About 40 percent of middle and high school students in the two provinces practiced regular sports at school less than two hours a week. Regular morning exercise and school sports were more common in girls than boys (p<0.00001), but regular extracurricular exercise and sports team membership were more common in boys (P<0.001). More than 77 percent of parents were unaware of the importance of childhood exercise in their children's health. The average TV viewing time for children of different ages was 4 hours a day.
Conclusion: The level of physical activity of middle and high school students in the central regions of Iran is less than the desired level and the duration of watching TV is more than the recommended values.

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Introduction: In order to determine the importance and power of physical examination diagnosis, we decided to compare the results of physical examination in patients with distal forearm penetrating wound and whatever is observed during surgery as golden standard. Materials and Methods: This cross-sectional analythical study was performed on 91 patients with distal forearm sharp injury. Findings of physical examination were compared to what was found during surgery (definitive diagnosis) as golden standard. Results: Based on findings, physical examination value of diagnosis for FDP and FDS was determined. In FDS clinical examination value had 88% sensitivity, 40% specificity, 94% positive predictive value, 22% negative predictive value and 1.46 positive likelihood ratio, and 0.3 negative likelihood ratio and FDP clinical examination value had 97% sensitivity, 25% specificity, 93% positive predictive value, 50% negative predictive value, 1.29 positive likelihood ratio and 0.12 negative likelihood ratio. Conclusion: Physical examination view point of rule in of flexor tendon injury because of sharp and penetrating trauma is more valuable than rule out.

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Background: Recognition of mortality-related factors in Intensive Care Units (ICUs) could increase efficiency and effectiveness of these units. This research determined the relationship between the physical structure, human resources and their relevance to mortality rate in Intensive Care Units. Methods and Materials: In this cross-sectional study, all ICUs of hospitals in Markazi province were considered. Data gathering tools were resource (human, physical and training) questionnaires and checklists which their reliability and validity were accepted by Monitoring and Validation Center of Ministry of Health. Mortality rate after 24 hours of admition was also determined in relation to hospital resources and activities. Data were analyzed with descriptive statistics, Spearman and Kruskal-Wallis tests. Results: Total score of human, physical and training resources in hospitals of Markazi Province is 55 percent of the country standard score. Mortality ratio after 24 hours of admission, to all patients (released and deceased patients) was highest in Vali-e-Asr hospital (25%) and lowest in Saveh Shahid Chamran Hospital (5%). There wasn’t significant difference in this ratio among hospitals. There were no significant difference between obtained scores of each resource (human, physical and training) among University, Social Insurance and Qods (private) hospitals with respect to mortality rate 24 hours of admission. Conclusion: Human, physical and training resources have not direct effect on decreasing mortality rate after 24 hours of admission but can create necessary conditions for providing higher quality services.

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  Introduction: Researches indicates that physical training are a basic component of pulmonary rehabilitation in asthmatic patients , and can result in improvement of sign and symptoms of asthmatic patients.The purpose of present study is evaluation of the effects of physical exercises on pulmonary function and clinical manifestations and signs and symptoms of asthmatic patients.

  Materials and methods: The samples included 24 asthmatic patients that participated in a physical exercise program have refered to Ardebil Bou _Ali Hospital (1386) .The researcher followed test –re-test design in the present study.

  The data were collected using an asthma clinical manifestations questionnaire and pulmonary function test (Spirometery).

  Results: Physical exercises program was effective in improvement pulmonary function of asthmatic patients, and exercises decrease asthmatic signs such as: attacks of wheezing, shortness of breath, chest tightness and coughing.

  Conclusion: The results indicate that asthmatic patients would benefit from a physical training and such a physical exercise program can be adapted for use in clinical practice.

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Background: Noticing the importance of measuring physical activity in medical investigations, this study was conducted to analyze the validity and reliability of the researcher-made Physical Activity Questionnaire (AFPAQ) of Azad and Fesharaki, so as to achieve a suitable tool. Materials and Methods: In this cross-sectional study, the sample population all army men selected through two-stage cluster sampling according to Morgan samples table. After investigating content validity, confirmatory and explanatory factor analysis, Pearson correlation (using general health questionnaire (GHQ) and test-retest coefficient were used to examine construct and predictive validity, respectively. Data analysis was done using SPSS software version 15 and Amos version 16. Results: This study was done on 724 subjects including 54 (7.3%) women and 685 (92.7%) men. The CVR coefficient was 60% for this study. Also, explanatory factor analysis showed three factors, including physical activity at work, physical activity at leisure time, and exhaustion with 45% total variance and 71% Kaser-Meyer-Olkin Index. These factors were also confirmed by confirmatory factor analysis (AGFI=0.963, RMSEA=0.053). The reliability of the questionnaire was %40 and %70 using Cronbach's Alpha and test-re-test method, respectively. Conclusion: Since validity and reliability indexes of the questionnaire were reported desirable, AFPAQ can be considered a valid and reliable questionnaire for measuring physical activity

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Background: Postpartum women are a population at risk for sedentary life. Previous studies have shown that self-efficacy is an important determinant of stage of change and exercise adherence. This study evaluates the relationship between self-efficacy and stage of change and physical activity (PA) behavior in Iranian mothers. Materials and Methods: In this cross-sectional study, 300 postpartum mothers were selected randomly from all health centers in Arak. The instruments used in this study included the 7-day PA recall, stages of exercise adoption tool, and self-efficacy for exercise scale. Data analysis was performed using SPSS software. Results: Ninety-one percent of the participants were in the pre-contemplation, contemplation, and preparation stages of change. Mean score for moderate PA was 38.94±40.5 minutes a week. Significant relationships were found between the stages of PA behavior change and METs of weekly energy expenditure from moderate activities (r=0.60, P<0.001). Also, statistically significant relationships were found between self-efficacy and the stages of PA behavior change (r=0.50, P<0.001) weekly energy expenditure from moderate activities (r=0.40, P<0.001), and pre-pregnancy PA behavior (r=0.39, P<0.001). Conclusion: The level of PA of the participants was less than the recommended minimum level for regular PA behavior (150 minutes of moderately intense PA per week). In this population, self-efficacy plays an important role in PA behavior and it should be taken into consideration in designing interventions for improving PA behavior.

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Background: Epidemiological studies have shown the relationship between incidence of asthma symptoms and environmental factors, such as sedentary lifestyle and metabolic and cardiovascular diseases. However, the role of exercise rehabilitation protocols on lung function in obese adult patients with chronic asthma is a controversial issue. The aim of the present study is to evaluate the impact of aerobic exercise on lung function in obese middle-aged men with chronic asthma. Materials and Methods: This semi-experimental study was conducted on 39 obese middle-aged males with mild and moderate asthma. The experimental group (n=19) with regard to the safe range 15≥ RPE>9 followed the sub-maximal rehabilitation exercise program (50 to 80% HRmax intensity) for 3 months. Then, they underwent one month of detraining. The control group (n=20) did not have any form of aerobic exercise. Spirometric parameters in base, three months of training, and one month of detraining were measured by standard methods. Results: Indicators of lung function, including FVC, FEV1/FVC, PEF, FEF%75, and MVV significantly decreased. The pattern of changes in FEV1, FEV1/FVC, and MVV remained stable even after a month of detraining (p<0.05). However, no significant changes occurred in the dependent variables of the control group (p>0.05). Conclusion: It seems that the incidence of physiological adaptations of aerobic exercise, as a non-pharmacologic clinical factor, after the one-month detraining period affected the spirometric parameters in obese asthmatic patients

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Background: Today, global concerns about water pollution with chemicals and its adverse impact on health have increased. This study aims to evaluate the physical and chemical quality of water treated through domestic water treatment systems.

Materials and Methods: In this cross-sectional descriptive study, water samples were collected from 60 domestic water treatment systems and parameters, such as turbidity, total dissolved and suspended solid, total hardness and calcium, magnesium hardness, alkalinity, total alkalinity, carbonate, bicarbonate, nitrate, sulfate, nitrite and fluoride, EC, pH, and free chlorine residuals, were examined.

Results: The results indicate that the average concentration of chemical parameters in treated water were: chloride=0.1mg/L, nitrate=0.006mg/l, sulfate=5 mg/l, Nitrate=15mg/L, bicarbonate=49 mg/L, calcium hardness=18 mg/L, and fluoride=0 mg/l.

Conclusion: The overall results of this study indicated that the use of municipal water treatment reduced Cl2, sulfate, and bicarbonate concentrations than the optimal levels in urban areas water. However, nitrite concentration was significantly higher in the output of these systems than distribution systems, which is a source of concern.

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Background: Due to high risk of physical inactivity in children with autism spectrum disorders (ASD) and its adverse consequences, evaluating their level of physical activity (PA) using accelerometry and investigating its relation with age and severity of the disorder are integral.

Materials and Methods: Fifty two boys and sixteen girls aged 7-14 years -from autism schools in Tehran- participated in current cross sectional study. Level of daily PA was evaluated for seven consecutive days using accelerometers. Autism severity was also assessed in the areas of communication, sociability, sensory and cognitive awareness, and health and physical behavior using Autism Treatment Evaluation Checklist (ATEC).

Results: On the whole 91 percent of participants encountered low level of PA. Girls were remarkably less active than boys and were more inactive. Level of PA significantly reduced as they aged. Level of PA was adversely and significantly correlated with autism severity in the area of sensory and cognitive awareness. Moreover, level of vigorous PA was adversely and significantly correlated with total autism severity. Finally, age, sex, and sensory and cognitive awareness were partially predictors of PA.

Conclusion: It appears that children with HFA are physically inactive and considerably engage in more sedentary activities as they age. Age and gender can be considered as physical activity determinants among this population.

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Background: The aim of this research was to determine the relationship between inflammatory markers (Fibrinogen, C-reactive protein (CRP) and Creatine kinase (CK)) and respiratory responses FEF25-75% (Forced expiratory flow in 25-75 percent) and FEV1 (Forced expiratory volume in one second) in 14-16 year’s Urmia city boys in response to an incremental physical activity.

Materials and Methods: The subjects were boys of 14-16 years among 24 healthy participants. These groups divided into two groups randomly, one group as trained one (n=12) and the othes as control group. Blood sample was taken in baseline and after Modified Balke Protocol in trained group, And the blood sampling was taken in baseline and 48 hours later in control group. respiratory responses were measured immediately after Modified Balke Protocol.

Results: CRP and Fibrinogen significantly increased in trained group (p<0.001) and this group had high level of these markers compared with control group (p<0.001). The association between CRP with FEF25-75% and fibrinogen with FEF %25-75 and CK with FEF 25-75% in trained group was significant (p&le0.05).

Conclusion: The results of this study show that incremental physical activity increased inflammatory factors in active children. Incremental exercise shows a strong relationship between some inflammatory markers and respiratory parameters in adolescents 14-16 years old.

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Background: The average age of menarche varies from country to country due to regional variation and different factors, including genetic and environmental factors that affect the onset of menarch. This study performed to survey relationship between nutrition and physical activity with menarche age of girls in Ahvaz city.

Materials and Methods: This survey is a cross-sectional study that was conducted on 1249 female students 8-15 years in 2012- 2013 year. Participants were selected by random cluster sampling from 4areas and 16 elementry and middle and high schoolsin Ahvaz city. The data were collected based on interviews and questionnaire (food frequency and physical activity). After collecting the data, then they were encoded and analyzed by SPSS16 software  and descriptive and analytic statistics.

Results: The mean of age at menarche in girls in Ahvaz was 11.86±1.07 and age at menarche was not associated with nutrition and physical activity.

Conclusion: Based on these findings, significant association between nutrition and physical activity and age at menarche (p<0.001)was not observed.

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Background: Obestatin and leptin are two important hormones in energy homeostasis that have been discovered in recent years. The purpose of this study was to investigate the effect of eight weeks of intense aerobic exercise on plasma levels of obestatin, leptin, insulin and growth hormones in male obese Sprague Dawley Rats.

Materials and Methods: In this exprimontal study 50 male rats, with the weight range of 20±320 were taken from the Animal Laboratory of Medical Sciences in Shiraz University, and were divided into two training groups: experimental and control. The exercise program consisted of 8 weeks of intense aerobic exercise, 5 sessions per week. The exercise started at a speed of 5 meters per minute and with a slope of zero degree for 15 minutes and the intensity progressively reached up to the speed of 25 m/m and the slope of 15 degrees for 75 minutes in the last week and ended. Blood samples were taken 24 hours after the last training session and were sent to the laboratory to measure the levels of obestatin, leptin, insulin and growth hormones. SPSS software and one-way analysis of variance (ANOVA) and Pearson correlation coefficient were used to assess the results.

Results: There was a significant reduction in plasma levels of obestatin (p=0.02), leptin (p=0.02), and insulin (p=0.03), while the results showed that no meaningful difference was observed in the amount of growth hormone between the control group and intense training group (p=0.07).

Conclusion: The results of the present study have shown that after sports activities leading to weight loss, the reduction of anti-hunger hormones (obestatin and leptin) is expected.

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Background: Cardiac troponin T and creatine kinase are used as biological markers for cardiomyocytes and its levels in serum are used as indicators of myocardial cell injury. The purpose of this study was to compare the effects of 3 different training protocols (runing, swimming, and pedaling training) on myocardial cell injury biomarkers in young girls.

Materials and Methods: In this semi-experimental study with pretest–posttest design, ten healthy young girls (aged 23.0±1.6 y) were selected in a convenience sampling way. The subjects performed three types of exercise in 7 days interval. Blood sample was assessed before and after the exercise sessions. Data were analyzed using t-test and analysis of variance.

Results: Our results indicated that creatin kinase increased significantly after three types of exercise (p<0.05). Running exercise led to greater increase in serum creatine kinase (p<0.05). Also, troponin T levels significantly were increased after three types of exercise (p<0.05), although no significant differences were observed between exercise types (p>0.05).

Conclusion: Our data suggest that intensive exercise is associated with cardiac damage in less trained girls and the type of exercise is determinants of the magnitude of myocardial injury biomarkers release.

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Background: The aim of this study was to determine the effect of preconception endurance exercise training with voluntary exercise activity during pregnancy in mother mice on lipid profile in adult offsprings.

Materials and Methods: Twenty four C57BL/6 female mice were randomly divided into four subgroups: trained in preconception period and exercised during pregnancy (TE)(20.3±1.02g); trained in preconception periods but unexercised during pregnancy (TC)(21.58±0.4g); untrained in preconception periods but exercised during pregnancy (CE)(21.02±0.23g); untrained and unexercised (CC)(19.23±0.45g). Trained mice were subjected to a protocol of moderate endurance exercise training over a period of 4 weeks for 5 days before pregnancy. The fasting blood samples were collected from adult mice(8 weeks old) and serum levels of glucose and lipid profile were measured. Data were analyzed using two way ANOVA and Tukey’s post hoc test.

Results: The Glucose test results in offspring showed that there was a significant interaction between group and sex and group main effect (p<0.001) Glucose levels of male offspring were significantly lower in TC and TE groups. Results on LDL also showed that the sex main effect was significant (p<0.001), and LDL levels of male born to TE and TC dams lower than in female offspring.

Conclusion: Improving the mother's physical fitness by providing regular endurance training in the preconception period and maintaining it by exercise activty throughout pregnancy may have potential for eliciting positive changes in lipid profile of offspring, specially males.

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Background: Mental health is an important aspect of health and the World Health Organization defines health as "full physical, mental and social welfare, and not merely the absence of disease". Given that 79 percent of the health education focused on physical aspects, in fact, the most focus is on biological parameters of people to measure their health. So we need a valid questionnaire to measure mentally and physically the health of people in the research community.

Materials and Methods: The Holistic Wellness Model reflects that the researches is done on health which is different in variant cultures perspectives.102 managers and officials of Islamic Azad University of Arak participated in this studyin 2014 and the validity and reliability of the questionnaire were analyzed using the software SPSS20.

Results: 102 people were enrolled in this study, 74 males (72.5%) and the rest were female. Cronbach' Alpha coefficient for the entire questionnaire was 0.93.In all six aspects which reviewed, the correlation between all questions and its perspective was measured by using Spearman test. There was a significant positive correlation among all the questions and the related aspects.

Conclusion: The Persian version of physical and mental health questionnaire, based on the Holistic Wellness Model, is suitable to assess the health of people. Also, validity and reliability is appropriate.

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Background and Aim: Coronavirus Disease 2019 (COVID-19) pandemic has reduced the physical activity of people worldwide. The purpose of this study is to provide a practical guide for performing physical activities at home during the COVID-19 pandemic.
Methods & Materials: The study was conducted by using library method and reviewing the books and articles on home-based physical activity, to provide a scientific basis for performing physical activity at home. In this regard, various physical activities with and without equipment at homes were examined.
Ethical Considerations: This article is a review article with no human or animal sample.
Results: Home-based practical suggestions for staying active and cope with its physical and psychological consequences of the COVID-19 pandemic were reported walking or running on a treadmill, the use of stationary bikes, and body weight resistance exercise, in addition to aerobic exercise.
Conclusion: This proposed physical activity programs can be used during the pandemic at home by people with sedentary lifestyle. 

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