Background: Early, complete, and stable coronary revascularization is the main criteria for standard treatment in patients with ST segment elevation myocardial infarction (STEMI). The aim of this study was to evaluate the safety and efficacy of integrilin as glycoprotein IIb/IIIa receptor inhibitor in treatment of STEMI patients undergoing primary percutaneous coronary intervention (PCI).

Materials and Methods: In this clinical trial study, 106 STEMI patients who complained of acute chest pain and were referred to Amir Al Momenin hospital, Arak, entered the study. Patients were randomly divided into two equal groups. The first group was treated with integrilin immediately before angioplasty. The 2nd group was treated with conventional percutaneous coronary intervention.

Results: After receiving treatment and undergoing angioplasty, TIMI Frame Count was equal to 15.7±8.04 in the 1st group and 14.2±5.4 in the 2nd group which showed no significant difference between them (p=0.4). Ejection fraction in patients receiving integrilin was significantly more than control group in first (p=0.043) and third month (p=0.012) after treatment.

Conclusion: Based on the results of the present study, it seems that using integrilin in standard time, causes long-term benefits for patients and reduces damage to the heart wall.

Background: Cardiovascular diseases is one of the most prevalent causes of mortality in all around the world accounting for high rates of decrease of physical function and daily work. The aim of this study is to assess the effect of cardiac rehabilitation on quality of life dimensions Percutanous Coronary Intervention (PCI) patients.

Materials and Methods: This clinical trial study was conducted on 96 patients in the rehabilitation unit in Qom. Half of patients put in the test group and the others remained as control. Data of all patients including of demographic parameter and questionnaire of quality of life before and after rehabilitation (in case and control groups) were collected. Data analysis was done in SPSS 18 by central statistical indices and frequency distribution as well as independent t-test, pair t-test ans Chi-square and p-value below than 0.05 was significant.

Results: out of 96 patients, the mean age was 57.21±9.09 and 57.3± 10.89 years in case and control groups respectively and 70.8% were male and remains were female. There was significant relationship between quality of life and its subtypes except physical function (p<0.001). Moreover, difference between quality of life and six out of eight subtypes scores before and after rehabilitation in both groups was significant.

Conclusion: It seems that cardiac rehabilitation after PCI affects quality of life.