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Showing 2 results for Pathogenicity

Yasamin Abdanankord, Hossein Dabiri, Hossein Goodarzi,
Volume 18, Issue 6 (9-2015)
Abstract

Background: Pseudomonas aeruginosa is one of the important causes of hospital infections septicemia, in patients hospitalized in burn ward and those with cystic fibrosis. Considering the PAPI-2 important role in bacteria pathogenesis, the aim of this study is to investigate the frequency of the encoding genes exoU and xerC as markers of PAPI-2 from isolated environmental and clinical samples.

Materials and Methods: In this descriptive study, 40 isolates from sewage of burn wound hospital and 30 from patients hospitalized in burn ward of the hospital covered by shahid Beheshti University, respectively. The frequency of PAPI-2 in both environmental and clinical strains was detected by using PCR and the primers exou and xerc.

Results: Of 40 studied environmental pseudominas aeruginosa strains that their genus and species were confirmed by chemical tests, 30 samples (75%) consisted of exoU gene and 32(80%) included xerC gene. Also, of 30 isolated strains of burn patients, 23 isolates(76.7%) contained both exoU and xerC gene. The results revealed a high prevalence of PAPI-2 (90%) between clincial and environmental samples of pseudomonas aeruginosa.

Conclusion: With due attention to the results, information reveal that the importance and prevalence of pathogenicity island type 2 were high in Iranian clinical and environmental Pseudomonas aeruginosa isolates. Also, considering all environmental isolates have at least one of genes, we should care about the risk of transporting pathogenic strains and find solutions to control it.


Ameneh Omidi, Somayeh Shatizadeh Malekshahi, Parsa Veisi,
Volume 23, Issue 5 (11-2020)
Abstract

Background and Aim: Coronaviruses are a large family of viruses that are known to cause respiratory tract infections in humans. SARS-CoV-2 is a new type of this family initiated in late 2019 and its related disease is known as Coronavirus Disease 2019 (COVID-19). Common symptoms of COVID-19 include fever, dry cough, fatigue, myalgia, arthralgia and shortness of breath.
Methods & Materials: In This narrative review a literature search was conducted in scientific databases including Google Scholar and PubMed to find studies published from December 2019 to May 10 2020 on the role the extrapulmonary manifestations of COVID-19. 
Ethical Considerations: Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors.
Results: In addition to respiratory symptoms, involvement of various organs such as gastrointestinal tract, nervous system, skin, olfactory system, cardiovascular system, liver, kidney, and eyes was also reported. Extrapulmonary manifestations of COVID-19 included anosmia, ageusia, skin rash, chickenpox-like blisters, acute cardiac failure with increased troponin levels, kidney inflammation and edema, common gastrointestinal symptoms (e.g. diarrhea, nausea and vomiting), elevated liver enzyme levels, neurological disorders (e.g. stroke), nonspecific symptoms (e.g. headache and dizziness), and decreased consciousness level.
Conclusion: The hypothetical mechanisms of various organ involvements during COVID-19 include immune-mediated inflammation such as cytokine storm, respiratory dysfunction, hypoxemia, cellular damage, or combination of these mechanisms. Further studies should be conducted on the causes of various COVID-19-induced damages to determine the exact relationship between the pathogenesis, prognosis and severity of the disease. 


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