Journal of Arak University of Medical Sciences

Search published articles

Showing 5 results for Osteoporosis

Evaluation of Application Prevention Behaviors of Osteoporosis Health Caregivers and How Them Educating for Women in Referred to the Health Care Centers of Arak City in 2002.

Fereshteh Narengi, Samereh Abdoli,
Volume 5, Issue 3 (10-2002)

Abstract

Introduction: Osteoporosis is an important health problem and the most common metabolic bone disease, that according data statistic, more than 6000000 Iranian have this disease.
Material and Methods: This research is a descriptive analytical study which has been conducted in order to evaluate application prevention behaviors of osteoporosis in health caregivers and how them educating for women referred to the health care centers of Arak City in 2002.
The research units were composed of 24 health caregivers 110 women referred to these centers that had been selected by convenience.
Results: The results of the research show medium age of caregivers were 33.7 years and in women were 29.3 years. (%58). Caregivers and (%80.9) women had adequate education intake daily and (%80.2) caregivers and (%16.4) women had regular exercise, (%62.5) Caregivers and %63.5) women exposed to the sunlight. Also the results show (%49.1) units research in the day gave discussion of caregivers about osteoporosis. (%79) intake calcium, (%90) exercise, (%85.5) exposing to the sunlight, but (%80.9) women did not discuss about taking hormonal drugs.
Conclusion: The result show significant relation between age, educational level and family history of osteoporosis in health caregivers with before education, but relation between adequate calcium intake in women and education was nonsignificant and relation between doing exercise and education was significant.

Evaluation of the role of alendronate in prevention of steroid-induced osteopenia in ALL and NHL in children

Aziz Eghbali, Afsaneh Akhondzadeh, Mohammad Rafiee, Fatemeh Dorreh,
Volume 16, Issue 4 (7-2013)

Abstract

Background: Osteopenia is a common and sometimes disabling consequence of the treatment of common neoplastic diseases, such as acute lymphoblastic leukemia (ALL) and lymphoma in children. The aim of the present study was to evaluate the preventing effects of alendronate on steroid-induced osteopenia in children with ALL and non- Hodgkin’s lymphoma (NHL).

Materials and Methods: In this clinical trial, 30 children with ALL and NHL were purposefully selected. All patients received the same induction chemotherapy protocol. Then they were randomly divided into two matched groups. All of them received equivalent supplement of 400 IU/d vitamin D and 30-40mg/kg/d calcium. The patients of the case group received 35mg/week alendronate for 6 months as well. Lumbar spine and whole body bone densitometry were performd before and after intervention and Z score was calculated for all patients.

Results: The mean age of the studied population was 6.11(±3.36) years and 15 of the children (50%) were male. There was no statistically significant difference in lumbar spine and whole body bone densitometry and Z score before and after intervention between the two groups (p>0.05). The improvement of bone densitometry and Z score were seen in both groups after intervention which was more in the case group but it was not statistically significant (p>0.05).

Conclusion: Administration of 35 mg/week alendronate for 6 months does not cause significant improvements in bone densitometry variables in children with ALL and NHL.

The Roll of TNF-α and IL-17A in Post-Menopausal Osteoporosis

Ahmad Reza Behruzi, Mohammad Hossein Hadi, Ahmad Reza Ghandi, Ghasem Mosayebi,
Volume 16, Issue 11 (2-2014)

Abstract

Background: Osteoporosis is characterized by low bone density and loss of structural integrity which can increase the risk of bone fracture and its side effects. In the recent studies, new evidences of the relationship between immune system such as TNF-&alpha and IL-17A and bone destruction have been accumulated. The aim of present study was to investigate serum level of TNF-&alpha and IL-17A in women with post-menopausal osteoporosis.

Materials and Methods: In this analytical study 40 women with post-menopausal osteoporosis and 10 healthy women were enrolled to the study based on inclusion and exclusion criteria. The serum level of TNF-&alpha and IL-17A were calculated by using ELISA method and compared between groups.

Results: The mean level of TNF-&alpha in case and control group was 957.7±479.01 and 418.09±176.7 respectively which in case group was significantly more than control group (p=0.001). The mean level of IL-17A in case and control group was 95.23±36.7 and 125.7±30.6 respectively which in case group was significantly less than control group (p=0.019).

Conclusion: The level of TNF-&alpha in women with post-menopausal osteoporosis was more than healthy women which can mention the roll of TNF-&alpha in pathogenesis of osteoporosis and potential therapeutic roll of anti TNF-&alpha agents but because of unclear roll of IL-17A in pathogenesis of osteoporosis we could not explain its mechanism in pathogenesis of osteoporosis. It seems more studies with regard to IL-17A roll in bone metabolism is required.

Association of Polymorphism of LRP4 Gene (rs 4752947) among Post Meno-pause Women with Osteoporosis in North of Iran

Saeid Kavoosian, Ali Mohammad Asgharian, Ramin Ataei ,
Volume 19, Issue 8 (11-2016)

Abstract

Abstract

Background: Osteoporosis is describesd as a disorder and skeletal disease that decrease bone strength and increases the risk of a bone fractures. Genetic factors have effect role in the progression of the osteoporosis. The aim of this study was to investigate the association between LRP4 gene polymorphism with osteoporosis in a population of postmenopausal women from north of Iran.

Materials and Methods: In this case-control study, 80 female patients with osteoporosis and 80 healthy females without osteoporosis with average age of 45-60 has been investigated. After DNA extraction from genome samples, polymorphism of LRP4 (rs4752947) gene have been investigated by PCR-RFLP method. Data were analyzed by SPSS software.

Results: Our results showed no significant relationship between polymorphism of LRP4(rs4752947) gene and the risk of osteoporosis disease in two patients and control groups. Also, AT genotype and TT genotype compared with AA genotype increased the chance of disease by 1379 and 3.5, respectively. In addition, TT alleles compared with AA alleles, increased the chance of osteoporosis up to 1.605 times.

Conclusion: Of course, more complementary studies considering other LRP4 gene subtypes with more individuals for better findings are needed.

Correlation Between Serum Calcium, Phosphorus, and Alkaline Phosphatase Indices With Lumbar Bone Mineral Density In Active And Inactive Postmenopausal Women

Bakhtyar Tartibian, Leila Fasihi, Rasoul Eslami,
Volume 25, Issue 1 (3-2022)

Abstract

Background and Aim Menopause is a period in a woman’s life that can be physically damaging. However, its effect on bone mineral density is still debatable. This study investigated the relationship between serum calcium, phosphorus, and alkaline phosphatase indices with lumbar bone mineral density in active and inactive postmenopausal women.
Methods & Materials The number of subjects was 55 active postmenopausal women and 60 inactive postmenopausal women aged 45 to 85 years. Serum indices of calcium, phosphorus, and alkaline phosphatase and anthropometric of the subjects were measured. The Pearson correlation coefficient test was used to analyze the research data. SPSS software v. 26 was used to analyze the data.
Ethical Considerations This study was approved by the Research Ethics Committee of Allameh Tabataba’i University with code IR.ATU.REC.1399.038.
Results The results showed a significant correlation between serum levels of alkaline phosphatase (P=0.021), calcium (P=0.019), and phosphorus (P=0.011) with lumbar bone mineral density in active postmenopausal women and also between body mass index with lumbar bone mineral density in both groups of active (P=0.014) and inactive (P=0.038) postmenopausal women. No significant relationship was found between other indicators.
Conclusion According to the results of the present study, being active may have had beneficial effects on bone metabolism and has led to a better state of bone mineral density. It may also help to use these blood and anthropometric variables in identifying people at risk for osteoporosis in adulthood and old age.

Page 1 from 1

Designed & Developed by : Yektaweb