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Background: Addiction is undoubtedly one of the biggest problems of human societies that every year governments spend enormous amounts of money on fighting it. Most addicts, besides their addiction, cause many psychological problems in their families therefore, the aim of this study was to compare the presence of these disorders between the families of addicts and non-addicts. Materials and Methods: This case-control study was done on a sample of 650 persons of opium addicts' and non-addicts' families using random sampling method. Data were collected through SCL-90-R questionnaire and were analyzed by Chi-square and t-test using SPSS software version 18. Results: There was a significant difference in psychiatric disorders in addicts' and non-addicts' families (p=0.005). Among the 9 psychiatric disorders under assessment, only anxiety, aggression, paranoia, and depression disorders in three types, including pathologic, borderline, and combined (pathologic-borderline), were significantly higher in addicts' families compared with non-addicts' families (p=0.005). Conclusion: Drug dependence disorder in one member of a family has a very important effect on the mental hygiene of the other family members and requires prevention and treatment in both.