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Introduction: Migraine is one of the widespread discases in the word, being 15-20 percent prevalent in women, and 6 percent in men. The attacks resulting from the migraine usually range from minor to major, and even may make the patient unable to work. Its dangerous and permanenet effects may also led to paralysis of different parts of the body. Therefore, it is necessary to do more investigations concerning diagnosis and drug treatments which can prevent the migraine attacks better.
Materials and Methods: The study was a randomized controlled trial which lasted for six months. The patients have been studied through different ways including case history, checkup. electroencephalogram (EEG), computed tomography scanning, blood sampling, kidney and liver function and starting time of the treatment. Successful treatment responses to control migrainc attacks using the prophylactic drugs. Valproate Sodium and Propranolol with tricyclic antidepression drugs, i.e., Amitriptyline and/or Nortriptyline were studied.
Results: Of 126 patients studied (31.8% were men and 68.2% women), 65.1% had normal EEG and 34.9% had abnormal EEG. The patients using Valproate Sodium with normal and abnormal EEG had successful treatment responses equal to 35% and 95.6%, respectively. Additionally, other patients using Propranolol with tricyclic antidepressant Amitriptyline and/or Nortriptyline with normal and abnormal EEGs had successful treatment responses equal to 61.9% and 28.6%, respectively. Statistically, the results were significantly different. However, there were not significant differences between interactive effects of the drugs in sexes, and sexes in EEG types. The most prevalent side effects due to Valproate Sodium and Propranolol with tricyclic antidepressant drugs, i.e., Amitriptyline and/or Nortiptyline were vertigo and exhaustation, respectively.
Conclusion: This study revealed that the best treatment to prevent migraine attacks was using Valproate Sodium tablets in patients with abnormal EEGs, and using Propranolol tablets along with Amitriptyline and/or Nortriptyline for those who had normal EEG.

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Introduction: Different groups of drugs are used for prevention of migraine headaches. Howevere, there are controversy about the afficacy of these drugs. Furtheremore, the priority of one to other group is not clear. This study was designed therefore, to compare the effects of Propranolol and Nimodipine on sevierity, duration and frequency of migraine headache.
Materials and Methods: In a clinical trial study, 102 patients with migraine headache refered to neurology clinic were chosen. Patients were devided into two drug groups. Group one received 40 mg Propranolol per day and group two received 30 mg Nimodipine. Data was collected by a questionnaire. Patients were asked to record the severity, duration and frequency of their migraine attacks. Data was analysed using t-test. p<0.05 was considered significant.
Results: The duration and severity of migraine attacks in Propranolol group were less compared to Nimodipine group (p<0.05). However, there was no statistical differences in the frequency of migraine of these two groups.
Conclusion: Propranolol seems to be more effective than Nimodipine in prevention of migraine headaches

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Introduction: Relationship between Multiple Sclerosis (MS) and primary headaches is not well recognized yet and the studies that have been done had different results. The aim of this study was to investigate the relation between primary headaches and multiple sclerosis. Materials and Methods: In this historical cohort study, 117 patients with actual MS were selected by convenience sampling as case group and 351 healthy subjects as control group. The incidence of primary headaches was assessed by a physician using a questannaire. Variables under investigation were age, sex, type of MS, Expanded Disability Status Score (EDSS), and characteristics of headache based on International Headache Society (IHS) classification. Data analysis was done using Chi-square, t-test, Fisher exact test, and logistic regression. Results: 53.8% of MS group and 27.4% of control group had chronic headaches (p=0.0001). Frequency of Migraine and tension type headaches among patients with headache in MS group were 73.1% and 26.98%, and in control group were 40.6% and 58.7% respectively. There was a statistically significant relation between Relapsing-Remitting MS and migraine headache (p<0.001).There was not any correlations between headache and using Interferone, MS duration, and EDSS. Conclusion: The results of this study indicate that primay headaches, especialy migraine without aura, are common in MS patients comparing to general population.

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Background: Tension headaches are the most basic reasons for referring to physicians throughout the world. Iron anemia, on the other hand, is the most common type of anemia among women who are in productive age in the world. This study was done to investigate the relationship between vascular headaches and iron anemia and to see the effect of iron tablets administration on the treatment of these headaches in women who are in productive age. Materials and Methods: In this quasi-control study, 50 women in reproductive age who had iron anemia and vascular headaches, referring to the neurologic clinic of Vali-asr Hospital in Arak, were selected and treated with ferrous sulfate tablets for three months. For verifying the treatment, patients' hemoglobin was monitored after one month, and in case of any significant increases in this value, the patients discontinued participating in the study. The number of headache attacks and the number of analgesics used before, through and three months after beginning the administration of ferrous sulfate were noted for all of the patients. Results: The mean number of the headache attacks one month before treatment, during the treatment and three month after the treatment were 19.6±28 , 14.2±11.2 , 13.3±11.8, respectively (p=0.0001) . In addition, the mean number of used analgesics before the treatment, through the treatment and three month after the treatment were 30.1±14.1, 14.3±11.2, 13.1±16.1, respectively (p=0.0001). Conclusion: It seems that using iron tablets can be useful in treatment of vascular headaches.

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Background: Migraine is one of the prevalent disabling disorders. Considering geographical differences in reported epidemiology and improving patients care, the aim of the present study was to evaluate epidemiologic, demographic and clinical characteristics in patients with migraine headache in Arak.

Materials and Methods: This cross sectional and descriptive study was conducted on patients with migraine headache referred to the neurology clinics of Vali-Asr and Imam Reza hospitals of Arak for 6 months. A questionnaire containing the demographic, epidemiologic and clinical data was filled by patients.  Finally, data were analyzed using SPSS 18.

Results: Among 820 patients with headache, 92 (11.21%) subjects were confirmed to have migraine headaches. Of the 92 patients, 54.3% were women and 45.6% were men. The mean age was 36.9±9.2 years old and 50% were married. The most common migraine triggers were stress (78.2%), sleep disturbances (65.2%), and fatigue (63%). The mean frequency of headaches was 6.9±3.5 attacks per month with an average duration of 11.1±4.5 hours per attack.

Conclusion: According to our results, the prevalence of migraine in women is more than in men. Dizziness, visual disturbances, nausea, no aura, headache is one-sided and pulsating are significantly accompanied by migraine. The number of consumed sedative pills in the month, brain imaging and a monthly fee of headache were significant. In total, clinical characteristics of migraine headaches in our patients were nearly compatible with the International Headache Society (IHS) criteria.

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Background: Migraine is a chronic neurological disorder that leads patients to avoid any kind of activities. Since different factors are involved in migraine incidence and its triggers, so drugs are used to prevent or treat it are so variable. Also, combined medications are used to relieve migraine. This study examined the effectiveness of self-control training on quality of life in patients with migraine.

Materials and Methods: Statistic population of this study included all migraine patients in Ardabil in 2014(Estimation: N=1150) that 40 patients were selected by convenience sampling. Demographic and disease information questionnaire and quality of life questionnaire (SF-36) were used to collect data in clinical centers. Multivariate analysis of variance (MANCOVA) was used to analyze data, because present research was a experimental and clinical trial with pre-test and post-test with control group.

Results: The results showed that there is a significant difference between mean in quality of life in migraine patients and control subjects. It means that physical health and mental health of quality of life was different between control and experimental groups after self- control training.

Conclusion: Self-control training can be used to enhance quality of life in migraine patients. These results have important and effective applications in the treatment of migraine patients. Generally, specialists of clinical centers can use this method alongside other treatment interventions.

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