Showing 3 results for Metronidazole
Hossein Sarmadian, Nader Zarinfar, Ali Fani, Fateme Marjan Mousavi, Farshideh Didgar, Mohsen Khaki, Azadeh Mohammad Bagheri, Maryam Karimi,
Volume 11, Issue 3 (9-2008)
Abstract
Background: Metronidazole has antibacterial and antiparasitic action. Therefore it can use for treatment inflammatory diseases as Crohn. The effect of metronidazole on human’s blood lipids to reducing levels of LDL and VLDL and increasing level of HDL is under investigation. Target of this research is consideration effect of metronidazole on hyperlipidemia case of death such as coronary artry disrase. Methods and Materials: This study is a triple blind clinical trial was done on 100 voluntaries between 25-65 years old. with hyperlipidemia. Samples divided in two equal groups. The first group received metronidazol, 500mg, BID, for 10 days, and control group received placebo with the same dose. Lipids of serum were measured before and after using drugs, then data analyzed by SPSS software. Results: In metronidazol group amount of total cholesterol, LDL and Triglyceride were significantly less than placebo group. HDL’s amount in metronidazole group was significantly more than placebo group. Conclusion: Significant effect of metronidazole on reducing harmful blood lipids and increasing useful blood lipids. It can be suggested a probable candidate in treatment of hyperlipidemia. Maybe it can use with this application. Although it needs to more study by meta analysis to validate this effect.
Hafizi Moori , Dolatian, Naghash, Moatar, Alavi Majd,
Volume 13, Issue 3 (9-2010)
Abstract
Background: Bacterial vaginosis is one of the most common infections in women at reproductive age. Although metronidazole is recommended as the first-line treatment, it has various side effects which make it difficult for patients to continue the treatment. Thus, the need is felt for finding a medication with fewer side effects. The aim of this study is to compare the effects of micosin vaginal cream (made of garlic) and metronidazole vaginal gel on treatment of patients with bacterial vaginosis. Materials and Methods: This study was a clinical trial which was conducted on 100 married women, aged 18-44, whose infection with bacterial vaginosis was diagnosed through clinical Amsel criteria. The participants were randomly divided into two groups of 50 persons each: Micosin vaginal cream and metronidazole vaginal gel. Patients identified with tricamona or candidiadis infections were excluded from the study. Treatment period in each group lasted for seven days. Clinical Amsel criteria and patient complaints were again checked 2 to 7 days after completion of the treatment period, and the side-effects were registered. Results: Following the treatment with micosin vaginal cream and metronidazole vaginal gel, patient complaints and clinical Amsel criteria showed a significant decrease (p<0.05), in a way that clinical recovery rates in micosin and metronidazole groups were 80% and 70%, respectively. Conclusion: Micosin vaginal cream seems to be an appropriate alternative for metronidazole vaginal gel in treatment of bacterial vaginosis.
Mohammad Matini, Samira Bakhtiarnejad, Dara Dastan, Amir Hossein Maghsood, Mohammad Fallah,
Volume 20, Issue 6 (9-2017)
Abstract
Abstract
Background: Trichomoniasis is one of the most common non viral sexually transmitted diseases worldwide. The aim of this study was to investigate the effect of Plantago lanceolata extracts on Trichomonas vaginalis.
Materials and Methods: In this study, after collection and drying of P. lanceolata, n-hexanic, ethyl acetate, methanol and hydroalcoholic extracts, they were prepared by maceration. Five clinical T. vaginalis isoleates subjected to extract suscebtibility testing, in comparison of metronidazole. Minimum inhibitory concentration (MIC) and minimum lethal concentration (MLC) tests were carried out in duplicate and repeated two times for each T. vaginalis isolate.
Results: The results showed that the extracts of P. lanceolata had potent antitrichomonal activity. The most antitrichomonal activity was related to ethyl acetate extract with the least MIC of 500 µg/ml and mean of 1525 µg/ml, after 48 hrs incubation. And also, the lowest antitrichomonal activity was related to hydroalcoholic and methanolic extract with the least and mean MIC of 2000 µg/ml. The results of MLC and MIC tests were identical and this finding confirmed the trichomonacidal activity of the extracts. The drug suscebtibility testing showed that the T. vaginalis isoleates were susceptibale to metronidazole ranging from 3.1 to 6.2 µg/ml with a mean and standard deviation of 4.2 ± 1.5 µg/ml.
Conclusion: This study showed that the extracts of P. lanceolata hav e a considerable activity on T. vaginalis parasite. Hence, further studies are needed to clear more details of antimicrobial properties of P. lanceolata compounds.
