Showing 9 results for Melatonin
Seyed Mohhamad Ali Shariat Zadeh, Ahmad Hamta, Ali Akbar Malekirad, Shariat Zadeh,
Volume 13, Issue 5 (2-2011)
Abstract
Sleep is one of the basic needs of human and any disorder in its natural flow in addition to creating psychological problems can reduce the individual performance. There are descriptions and references about sleep and its features in Quran. In Naba Surش sleep has been referred to as a weakness that indicates a disease state. However, the conditions for the occurrence of sleep can be inferred from Kahf Sura, verse 11, which states: “a major quality of sleep is that one cannot estimate its duration”. In several other verses, sleep is said to be similar to temporary death. Substances such as endorphins, cortisol, and encephalin cause euphoria and have direct impacts on different parts of the body including skeletal muscles that lead to muscle comfort during the day. The amount of secretion of these materials into the body in the morning hours significantly increases. Therefore, waking up early in the morning can bring about euphoria and can have positive impacts which last till the end of the day. According to the findings released by the International Agency for Research on Cancer World Health Organization, men and women who work night shifts are at a greater risk of developing breast cancer and prostate cancer, respectively. Night sleep is a divine blessing that God has endowed people and God in verse 23 of Rome Sura refers to sleep as “one of the signs revealed to people” and asks people to search and investigate about it so as to realize to what extent night sleep can contribute to human perfection and success
Kazem Biabani, Ahmad Zare, Hamid Kohram, Mehdi Khodaeimotlagh,
Volume 15, Issue 10 (3-2013)
Abstract
Background: Heat stress reduces reproductive performance in farm animals. The aim of this study was to determine the effect of heat stress and different concentrations of melatonin on nuclear maturation of ovine oocytes. Materials and Methods: In this experimental study, ovary collection and oocyte recovery were carried out by standard methods. Oocytes culture was in A: TCM199+10% FBS, 5µg/ml FSH, 0.01IU/ml LH, 100 IU/ml penicillin, and 100 IU/ml streptomycin, B: A+heat stress at 40 C0, and C and D:B+1 and 10 µM melatonin, respectively. Results: Heat stress significantly (P<0.05) decreased nuclear maturation in the treatment group in comparison with the control group (60.60 vs. 84.89). Also, 1 and 10 µM melatonin could improve oocytes to reach metaphase-II stage (60.60 vs. 76.92, 78.82, respectively). However, increasing the melatonin dose from 1 to 10 µM did not alter oocytes maturation. Conclusion: Overall, this study showed that melatonin improves ovine immature oocytes maturation during heat stress.
Alireza Jamshidi Fard, Haleh Rafipour, Fardin Faraji,
Volume 16, Issue 5 (8-2013)
Abstract
Background: Several clinical studies suggest that melatonin is a neuroprotective molecule in neurodegenerative disorders and it showed to be reduced in Multiple Sclerosis (MS) patients. MS also results in blurred vision, papillitis and diplopia. The main objective of the study was to asses the influence of Melatonin supplimentation on visual characteristics in patients with MS.
Materials and Methods: In a Quasi Experimental plan, approved by AUMS ethical Committee, 34 (9 males and 25 females) patients with stable MS were asked to voluntearly participate in the study. All subjects (Mean EDSS 3.14) were taking their routine medications. Visual funtions were evaluated by Visual Functioning Questionnaire (VFO-25) and standard Pattern Reversal Visual Evoked Potentials (PR-VEP) records. Serum Melatonin levels were also measured using an ELISA assay. Recordings were performed after a single dose and after taking 1 tablet every night for 14 days, at the day 16th.
Results: In all subjects, Serum Melatonin levels were significantly enhanced. VFQ scores also showed significat improvement. Except the change in N75 latencies of left eyes, VEP latencies of P100, N145 of both eyes and N75 of right eyes were significantly (p<0.05) reduced.
Conclusion: Our findings suggest significat improvements of visual symptoms of MS after daily intake of 3 mg Melatonin. The results calls for further studies and clinical trails before asking all MS patients to take Melatonin suppliment every night.
Reza Talebi, Abbas Alimoradian, Mehdi Sadegh,
Volume 18, Issue 6 (9-2015)
Abstract
Background: Oxidative stress and severe neuro-excitation have significant effects on pathogenesis of Parkinson’s disease and agents with antioxidant property can potentially prevent these effects. Herein we examined potential protective effects of melatonin as an antioxidant agent and memantine as an uncompetitive receptor of NMDA, on a model of Parkinson’s disease induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP).
Materials and Methods: Male mice were divided into 8 groups with 7 mice in each group: saline, ethanol, melatonin, memantin, MPTP, melatonin+MPTP, memantin+ MPTP, melatonin+ memantin+ MPTP. All of agents were injected intraperitoneally once a day for 14 days before beam traversal test. Dopaminergic neurons of the Substantia Nigra Pars compacta (SNPC) were determined by immunohistochemical and were counted.
Results: Melatonin improved notably movement dysfunction resulted of MPTP such as the number of errors, paces and the time of movement during behavioral test and also the counting of neurons of Substantia Nigra Pars Compacta. Memantin had a synergic effect on the most of improvements. However, the level of improvement and retrieval of signs was not as in saline and ethanol groups.
Conclusion: Melatonin especially together with memantine is able to prevent some of the MPTP-induced dysfunctions. However, the protective effects were not enogh, probably because of the amount of dose and the time of injection.
Elham Soleimani, Iran Goudarzi, Kataneh Abrari, Taghi Lashkarbolouki,
Volume 19, Issue 2 (5-2016)
Abstract
Background: Few studies have investigated the possible ways to prevent lead induced defects during gestation and lactation. The aim of this study was to investigate the effect of melatonin as a hormone with antioxidant properties on oxidative stress in the hippocampus and learning and memory impairment induced by administration of lead.
Materials and Methods: Pregnant rats were exposed to treatments of control, lead acetate (0.2% solution in water), lead acetate + melatonin and melatonin (10 mg / kg by oral gavage) from gestation day 6 until weaning. 21 days after birth, the activities of several antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) as well as malondialdehyde levels in hippocampus of 23 male offspring rats were assayed. To behavioral studies, on postnatal day 30, 57 rats were trained 6 days in the Morris water maze and the probe test was performed 24 h later.
Results: The results showed that administration of lead during pregnancy and lactation could increase MDA levels and decrease glutathione peroxidase, superoxide dismutase and catalase antioxidant enzymes activities in the hippocampus of male offspring. Also, this treatment significantly disrupted performance of the Morris water maze test and impaired learning and spatial memory in male offspring compared with control. Administration of melatonin attenuated lipid peroxidation and could improve learning and spatial memory deficits and the activity of antioxidant enzymes in lead exposure group.
Conclusion: Melatonin as a neuropotective drug can protect the hippocampus against the complications of lead exposure, in the course of development.
Abbas Alimoradian, Mohsen Shamsi, Fardin Faraji, Mehdi Ahmadi, Sayyed Ebrahim Sayyedi,
Volume 21, Issue 2 (5-2018)
Abstract
Abstract
Background: Multiple sclerosis (MS) is a myelinating inflammation and an impairment of neuronal cell regeneration in the central nervous system with unknown causes. The aim of this study was to evaluate serum melatonin levels in the treatment of patients with multiple sclerosis.
Materials and Methods: A prospective study and a Cohort were conducted on 40 MS patients with multiple sclerosis patients referring to instituate MS in Arak city for one year. In this study, patients who were treated with interferon-moderating drugs and who had not been treated for more than one year were randomly selected. A questionnaire containing demographic information and clinical information and separation of interacting factors was completed and completed. Clinical information included MRI, VEP, EDSS (Expanded Disability Status Scale) score, and clinical symptoms. The patients also received peripheral blood samplers 3 times in 6 months intervals to measure melatonin and their melatonin levels, and then the relationship between the data obtained from the patient's clinical data, EDSS, serum melatonin levels using the software SPSS with ANOVA and Post-hoc statistical analyzed.
Results: In patients with MS, in spite of receiving drug treatment, the level of melatonin as an antioxidant decreased in second order sampling, which is consistent with the deterioration of the patient's clinical condition (EDSS test), and this is not observed in the control group.
Conclusion: According to the findings of this study, it can be argued that the level of melatonin is a measurable objective and measurable variable (with the help of ELISA) that can be used in the follow-up of these patients, along with clinical evaluations and questionnaires.
Farzaneh Fuladi Targhi, Fardin Faraji, Ali Akbar Maleki Rad, Keyvan Ghassami, Afsoon Talaei,
Volume 21, Issue 6 (12-2018)
Abstract
Background and Aim: Multiple Sclerosis is (MS) is a common demyelinating disease of CNS that inflammation and stress oxidative processes have an important role in clinical courses and progression of it. The aim of the present study was to determine the anti-inflammatory effects of Melatonin on fatigue in MS.
Materials and Methods: In a double-blind clinical trials study, 62 patients with relapsing remitting MS were randomized to oral Melatonin 3 mg or placebo daily for 8 weeks. Scale of Fatigue in MS was studied by assessing FSS (Fatigue Severity Scale) on weeks 1 and 8.
Findings: 47 patients in intervention group and 15 patients in placebo group completed the study. In intervention group, treatment with Melatonin produced a significant decrease in FSS vs placebo group (before intervention: the average of FSS in patient group was 32.04±13.97 and in control group was 35.86±15.44; after intervention: the average of FSS in patient group was 30.42±12.40 and in control group was 41±12.66). Although in control group, the average of FSS was 35.866 and it was 41 after intervention. Because the score of placebo patient is near or upper than 36, this study suggested that Melatonin has a significant effect on improving and decreasing fatigue in MS.
Conclusion: The use of melatonin alongside of First-line drugs such as mitoxantrone, IFN – B or glatimer acetate can improve fatigue and disability in patient with MS.
Mohammad Ranjbarian, Korosh Etemad, Fatemeh Zarei, Rozita Farhadi, Jalaledin Sa´di,
Volume 24, Issue 1 (3-2021)
Abstract
Background and Aim: It is almost impossible to imagine life without electromagnetic waves. Such waves play a key role in the function of melatonin and create numerous diseases.
Methods & Materials: This descriptive-analytical study was conducted on 230 kV substations in Golestan Province, Iran in 2016. In total, 44 workers of electrical substations (the case group) and 23 workers of healthcare centers (the control group) with 24-hour shift works were enrolled in this study.
Ethical Considerations: This study was approved by the Ethics Committee of Shahid Beheshti University Medical Sciences( Code: IR.SBMU.THNS.REC.1395.9).
Results: The obtained data suggested that 100% of the electric field intensity and the magnetic flux density measured at the substations were within the permissible range of occupational exposure. The mean level of melatonin in the case group was lower than that in the control group; however, no significant difference was observed in this regard (P=0.761). Additionally, there was no significant difference between melatonin level and age (P=0.381), work experience (P=0.213), job groups (P=0.515), and employee activity area (P=0.482).
Conclusion: According to this study, no significant relationship was observed between electromagnetic waves and melatonin levels. Moreover, electromagnetic waves were within the permissible exposure. Thus, electromagnetic waves did not affect the level of melatonin hormone in male employees of 230 kV substations in Golestan Province. However, there was a decrease in the case group, compared to the controls. Therefore, definite comments require further investigation.
Neda Kafi, Amene Barjaste Yazdi, Rambod Khajei, Mohammadreza Hoseinabadi,
Volume 26, Issue 2 (7-2023)
Abstract
Introduction: The purpose of this research was to investigate the effect of a period of resistance training and melatonin consumption on sex hormone levels, pain intensity, and sleep quality in girls with primary dysmenorrhea.
Methods: For this purpose, 60 girls with moderate primary dysmenorrhea disorder (score 4-7) were randomly placed in 4 groups: resistance training + melatonin, resistance training + placebo, melatonin supplement group, and control group. Pain intensity, and sleep quality were assessed by the McGill questionnaire, and the Pittsburgh questionnaire respectively. 10 mg of melatonin was taken daily in two 5 mg capsules and the placebo group received the same amount of carbohydrates in the same capsule. Weight training, three days a week for eight weeks. This circuit exercise training was in 9 stations and with a maximum of 10-12 repetitions at 30-65% of a maximum repetition in each station. Each set and repetition was separated by 2-3 minutes and 90 seconds of rest, respectively. The blood sample was taken in the morning, fasting and 5 cc from the brachial vein from the left hand while sitting in the sitting position, and was taken by special kits. Data were analyzed by ANOVA with repeated measures and Bonferroni post hoc test at level P<0.05. All experimental procedures were approved by the Ethics committee of the Sport Sciences Research Institute of Iran (Code: ID IR.IAU.NEYSHABUR.REC.1401.008), Clinical Trial (Code: ID IRCT20230703058653N1) from the Iran Clinical Registration Center and were conducted under the Declaration of Helsinki.
Results: A significant increase in Estrogen (P<0.001) and progesterone (P<0.001) levels in the exercise + supplement group compared to all groups, and in the exercise + placebo group and the supplement group compared to the placebo group was reported. Also, The decrease in Pain intensity (P<0.001) and sleep quality (A decrease in the sleep score means an increase in the sleep quality in the output of the questionnaire) (P<0.001) in the supplement group compared to all groups and in the exercise + placebo group (P<0.05) and the exercise + supplement group compared to the placebo group showed a significant difference.
Conclusions: It seems that synergy of exercise and melatonin has affected the sex hormones level. Also, the melatonin probably helped to improve the sleep quality and pain intensity of the subjects through the adjustment of sex hormones following dysmenorrhea. Also, exercise probably has an effect on the pain intensity and sleep quality through the release of beta-endorphins and the effects of exercise on the menstrual cycle, although the finding are ambiguous.
