Showing 4 results for Ldl
Touba Kazemi, Hossain Panahi Shahri, Maryam Hossaini Farash, Mahdi Darabi, Mohsen Kashanian, Hossain Akbari,
Volume 8, Issue 3 (1-2006)
Abstract
Introduction: Hyperlipidemia is one of the main known risk factors for coronary artery disease. Regarding the undesirable consequences of hyperlipidemia and its long-term treatment, it is important to use drugs with lesser complications during the long period of treatment.
Materials and Methods: This study was a double-blind randomized clinical trail that carried out on 65 patients with hyperlipidemia. Patients were divided into two groups. Case groups took dill pearl, and control group took placebo pearl for one month. Serum lipids of both groups were measured before and one month after interference. Data was analysed with t-test and p<0.05 was considered significant.
Results: In this study , differences between mean level of cholesterol, triglyseride, HDL and LDL in case group before and after interference were statistically significant (P<0/05) but in control group only difference between HDL before and after interference was significant .
Conclusion: Regarding the result of the study dill pearl can be a useful drug for treatment of hyperlipidemia.
Fatemeh Shayesteh, Effat Farrokhi, Manochehr Shirani, Mehrdad Modarresi, Farshad Roghani, Morteza Hashemzadeh,
Volume 13, Issue 4 (1-2011)
Abstract
Background: Familial hypercholesterolemia (FH) is a disorder with autosomal dominant pattern caused mainly by mutations in the low-density lipoprotein receptor (LDLR) and apolipoprotein B-100. The aim of this study was to investigate the frequency and type of LDLR gene mutations in an Iranian population of patients with high blood cholesterol. Materials and Methods: In this descriptive-lab based study, a total of 50 non-related possible FH subjects from Cheharmahal Bakhtiari were studied. All subjects were tested for presence of LDLR gene mutations in 9 exons of the LDLR gene including 2, 4, 6, 7, 8, 9, 10, 12, and 14. The shifted bands were detected on electrophoresis gels and confirmed by subsequent DNA sequencing method. Results: Overall, four different polymorphisms were identified in 18% of the patients. We found 1413G>A, 1725C>T and 1773C>T, 2140+5G>A in 2,23,2 and 2 subjects respectively from which 1413G >A and 1773C>T were detected in both alleles of the gene. Conclusion: The results did not indicate the involvement of LDLR gene mutations of FH in the samples studied.
Ali Zarei, Saeed Ashtiyani, Fatemeh Rasekh, Ali Asghar Mohamadi, Ayob Gabari,
Volume 14, Issue 2 (5-2011)
Abstract
Background: Hyperlipidemia is an important risk factor for cardiovascular diseases. In this study, the effects of physalis alkekengi extract on the levels of cholesterol, low density lipoproteins (LDL), high density lipoproteins (HDL), and triglycerides (TG) were evaluated.
Materials and Methods: In this experimental study, fifty adult male Wistar strain rats were selected and divided into five groups of ten: Control group with a normal diet, control group with a high fat diet receiving interpritoneal injection of saline for 21 days, and treatment groups with fatty diets which received maximum (0.1 g/kg), moderate (0.2 g/kg), and minimum (0.4 g/kg) dose interpritoneal injections of the extract. After this period, blood sampling was done and the obtained results were analyzed through SPSS software.
Results: According to the obtained results, LDL and cholesterol concentrations decreased significantly (P<0.05), whereas HDL and TG plasma concentrations did not reveal any significant changes.
Conclusion: The findings of this study show that such changes are mainly due to the lycopene existing in the plant. Lycopene is a strong antioxidant which inhibits the production of LDL and presumably increases the excretories through releasing cholesterol therefore, it reduces blood cholesterol level and controls cholesterol synthesis.
Atefeh Biabangard Zak, Masoud Golalipour, Gholamreza Hadadchi, Alireza Abbaspour,
Volume 17, Issue 11 (2-2015)
Abstract
Background: Due to the changing lifestyle in terms of nutrition and physical activity, obesity has become one of the major challenges to human health. The study of metabolic factors involved in this phenomenon plays an important role in preventing and treating the obesity. The aim of this study was to investigate the relationship between testosterone level and serum lipoproteins such as LDL and HDL with Body Mass Index (BMI), in different age groups of men in Golestan population.
Materials and Methods: In this case-control study, 183 men were randomly selected during 2012. Anthropometric measures (weight and height) were obtained according to standard methods, and BMI was calculated for each one. Data was analyzed using SPSS version 16. Pearson bivariate correlation test between groups and one-way Anova test was performed and p<0.05 being considered as significant.
Results: Data analysis showed a significant inverse correlation between BMI and serum testosterone level (p=0.005). In the study population, higher BMI was associated with increased LDL level (p=0.049) and also increasing age (p=0.011). In addition, an inverse relationship was observed between BMI and HDL levels that were not statistically significant (p=0.068).
Conclusion: The results of this study indicate that weight gain is associated with increased LDL and low testosterone serum level, and this relation is more meaningful in old men.
