Mojtaba Eizadi, Farzad Nazem, Asghar Zarifyan, Anoosh Eizadi, Hossein Dooali,
Volume 13, Issue 1 (4-2010)
Abstract
Background: The purpose of this study was to determine the effect of L-carnitine supplementation on glucose and lactate concentrations, and aerobic capacity during sub-maximal exercise on ergometery cycle. Materials and Methods: In this double- blind clinical trail, 34 healthy noathlete male students at Saveh University were divided into experimental (L-carnitine usage) and placebo (lactose usage) groups and had one trial of cycling on ergometer (PWC170). This trial was done in two stages: 1) Exercise protocol without L-carnitine or placebo supplementation, 2) Exercise protocol with 3g L-carnitine (90 minute before exercise) and placebo supplementation in the experimental and placebo groups, respectively. Immediately after the physical exercise, blood sampling was taken for determining plasma glucose and lactate concentrations, and lactate dehydrogenase activity (LDH). Through polar telemetry rest and sub-maximal heart rate, and also, VO2max were measured. Results: L-carnitine supplementation had no influence on plasma glucose and lactate concentrations. Otherwise, rest and sub-maximal heart rate, VO2max and LDH activity were equal in pretest and posttests. All variables remained with no change in control group. Conclusion: Regarding the effect of L-carnitine usage on performance of endurance exercises, the findings are still vague and controversial. Our findings indicated that ingestion of 3g L-carnitine 90 minutes before exercise did not affect the dependent variables. Further investigation is required to determine the direct effect of such supplementations on substrate utilization, fat-carbohydrate metabolism and performance on exercise.
Mojdeh Fattahzadeh, Mohammad Amin Edalatmanesh,
Volume 21, Issue 1 (4-2018)
Abstract
Abstract
Background: Monosodium glutamate (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. The excessive use of MSG has been shown to increase oxidative stress in different regions of the brain. In this study, the neuroprotective effect of L-carnitine was investigated against MSG intoxication in granular cell of cerebellum in rats.
Materials and Methods: 48 adult male Wistar rats were randomly divided into 6 groups: the control, sham (normal saline treated), MSG (3%), L-Carnitine200, MSG+L-Carnitine100 and MSG+L-Carnitine200. After 30 days of treatment, through transcardialy perfusion, the rats were sacrificed and histopathological analyses were conducted on cerebellum.
Results: The results indicated that the density of granular cells in cerebellar folium IV, V and VI of rats in the MSG group had significantly decreased in comparison to that of the control and sham groups. Furthermore, the MSG+L-Carnitine200 group showed the higher density of granular cells compared with the MSG group in the three folia.
Conclusion: Treatment with L-Carnitine could protect the granular cells in cerebellum against MSG intoxication in rats.
