Showing 2 results for Intraperitoneal
Shaabanali Alizadeh, Masoome Kalantari, Khadije Ahrari,
Volume 12, Issue 1 (5-2009)
Abstract
Background: Hydatid cyst, a parasite disease, can involve liver more than other organs. The most serious complication of the cyst is rupture which may spread out to biliary duct, hollow organ, or abdominal cavity directly. Elective treatment is emergent surgery. Case: A 28 rural woman referring with abdominal pain, nausea and vomiting due to car accident. Abnormal findings consisted of: abdominal distention, reduction of bowel sounds, tenderness and generalized guarding and hive lesions in the anterior chest wall, upper abdomen, and both forearms. In sonography, a lot of free liquid in abdominal and pelvic cavity, and three hetroechoic masses in the right lobe of the liver were reported. Four days after abdominal surgery the patient was discharged with Albendazole order. Conclusion: Intra-abdominal rupture of hydatid cyst is the most serious that due to trauma complication and elective treatment is emergency surgery.
Roya Fatemi Nejad, Mohammad Reza Dayer, Mehran Dorostghoal, Mohammad Reza Parishani,
Volume 28, Issue 4 (10-2025)
Abstract
Introduction: Botulinum neurotoxin protein (Botox) is widely used for cosmetic purposes to reduce facial wrinkles without regard to its side effects. The present study was conducted to investigate the effects of Botox on blood biochemical factors and the kidney tissue structure of female rats.
Methods: In this study, 28 adult female Wistar rats were selected and randomly divided into four groups (n = 7). The first three groups received intraperitoneal injections of Botox (in the lower third of the abdomen, one centimeter below and to the left of the navel) at doses of 4, 6, and 8 units, respectively, while the fourth group (the control group) received a saline injection. Then the animals were kept in the animal house for three months with full access to food and water at a temperature of 22°C and a 12-hour light-dark cycle. Following a 24-hour fasting period at the end of the study, blood samples were collected via cardiac puncture under ether anaesthesia. Then, the animals were euthanized without pain, and their kidney tissue samples were extracted for histological examination.
Results: Biochemical results indicated a significant increase in serum creatinine levels following injection with 6 and 8 units of Botox, indicating renal impairment. Although the increase in the amount of serum uric acid levels compared to the control group did not reach statistical significance at the 95% confidence level (P < 0.05), it showed significance at the 94% level (p < 0.06), suggesting primary renal damage. Histopathological examination demonstrated that intraperitoneal injection of 8 units of Botox induced scattered and limited structural alterations in renal tissue, including vacuolar degeneration of tubular epithelial cells.
Conclusions: The results of this research show that the long-term and repeated use of Botox may cause significant renal damage in addition to local lesions and threaten a person's life.