Showing 4 results for Immunoglobulin
Saeed Kianbakht , Ali Ghazavi, Zahra Ghafari , Masoumeh Kalantari, Marjan Mehri ,
Volume 6, Issue 1 (3-2003)
Abstract
Introduction: Saffron (crocus sativus L.), an important spice rich in carotenoids, is used in folk medicine to treat numerous diseases. This study examines the effects of saffron consumption on innate and humoral immunity of healthy male students.
Materials and Methods: 41 healthy volunteered university students in two control and case groups were included in this study and consumed respectively milk and milk containing saffron for 6 weeks. Blood samples were collected from the subjects at weeks 0, 3 and 6. Innate immunity was evaluated by determining the percentage and counts of monocytes, neutrophils, eosinophils, basophils, platelets and the total white cells, CRP concentration and C3 and C4 concentrations and humoral immunity was assessed by deterning the percentage of lymphocytes and the concentrations of IgG, IgM and IgA.
Results: Three weeks after saffron consumption, monocytes percentage and IgG concentration increased significantly (P<0.05, P=0.01). Total white blood cells and platelets count also reduced significantly (P<0.05). After 6 weeks, monocytes percentage and IgG concentration reduced significantly (P<0.05, P< 0.001) and platelets count increased significantly (P<0.05) as compared with week 3.
Conclusion: This investigation demonstrated that saffron consumption enhances innate and humoral immunity systems and has anti-inflammatory effects. These effects depending on the duration of saffron consumption.
Ali Ghazavi, Afsaneh Zarganjfar, Ghasem Mosayebi , Bahareh Ghasemi, Shima Ghazali,
Volume 6, Issue 4 (12-2003)
Abstract
Introduction: Preclampsia is a pregnancy-specific condition characterized by hypertention, proteinuria and generalized edema. The condition usually occurs in the third trimester and word wide is one of the most common causes of maternal mortality and morbidity. No study concerning the immunological etiology and pathogenesis of preclampsia has been done in Iran. The aim of this study was to evaluate the role of some immunological factors involved in the pathogenesis of preclampsia.
Materials and methods: This research was a clinical trial study. We measured C3, C4, IgG, IgA and IgM levels in 20 women with preclampsia, 20 normal pregnant women and 20 non-pregnant women matched for age, BMI, parity and gestational age. Seven patients had developed severe and thirteen mild preclampsia. After written informed consent was obtained, blood samples of subject group.
Collected serum collected was analyzed for immunological parameters by the single radial immunodiffusion (SRID) method of Mancini.
Results: C4 level was significantly decreased in women with severe preclampsia than in women with mild preclampsia and normal pregnancies, whereas C3 level did not differ between groups. IgG concentration was significantly higher in non-pregnant women than in women with preclampsia and normal pregnancies. There was a significant decrease in IgA concentration in normal pregnant women compared with non-pregnant women. There was a not significant difference between the IgM concentrations of both groups.
Conclusion: Our data show several changes in immunological factors in preclampsia which may contribute to the pathogenesis of the disorder in Iranian women.
Hassan Ehteram, Elahe Mesdaghinia, Tahereh Mazoochi,
Volume 12, Issue 1 (5-2009)
Abstract
Background: Hyperemesis Gravidarum is the pernicious vomiting during pregnancy that causes various complications. This present was investigated to relationship between Helicobacter Pylori and Hyperemesis Gravidarum. Methods and Materials: 80 women with 7-16 gestational age, participated in this case-control study. It was done in Obstetric Clinical of Shabihkhani Hospital in Kashan from April to July 2008.The case group had Hyperemesis Gravidarum but the control group did not. The criteria for Hyperemesis Gravidarum were pernicious vomiting (more than 3 times a day) and the presence of one pluse ketonuria. Serum titre of anti Helicobacter pylori IgG with standard ELAZA kit in each group then compared. Chi square test was applied for data analysis and significancy was P-Value less than 0.05. Results: The mean of age was 25.4±4.5 in case and 22.4±4.6 in control group. There were no statistically significant differences in age, gestational age, gravity and parity between two groups. The frequency of Helicobacter Pylori was 75% in case and 35% in control group. Difference was significant (p=0.001). Conclusion: In this study, significant relationship between Hyperemesis Gravidarum and Helicobacter Pylori was seen. Regarding to Helicobacter Pylori causes peptic ulcer and hyperemesis imitates some Peptic ulcer symptoms, more studies should be carried out to determine this relationship.
Azam Zarneshan, Mohammadreza Zolfaghari, Mahdia Gholamnejad, Mehdi Yousefi,
Volume 20, Issue 8 (11-2017)
Abstract
Abstract
Background: IL-4 plays a key role in the pathogenesis of asthma and the increased serum level of that is positively correlated with asthma severity and obesity. IL-4 induces IgE secretion by B cells. Previous studies suggesting an anti-inflammatory effect of exercise training on asthmatic lungs. The aim of the present study was to investigate the effect of 12 weeks of aerobic exercise training on serum levels of IL-4 and IgE in overweight and obese asthmatic women.
Materials and Methods: 21 overweight and obese asthmatic women were selected and divided into two groups including experimental (n=12) and control (n=9) groups. The experimental group performed aerobic exercise training, three times a week, 60 minutes each session. Fasting blood samples were collected before and 2 days after completion of the course. The data were analyzed by using SPSS22 software
Results: A significant decrease in serum IL-4 (p = 0.015, t = - 2.68), BMI (p = 0.014, t = - 2.72) and weight (p = 0.001, t = -3.99) was shown following the 12 weeks of training in the experimental group compared to the control group. There were no significant correlations between the obesity changes and the Inflammatory Marker Changes (p>0.05).
Conclusion: The present study indicates that aerobic exercise training reduced the serum levels of IL-4 independent of obesity changes in overweight and obese asthmatic women.
