Showing 30 results for Icu
Dr Mehri Jamilian,
Volume 9, Issue 1 (3-2006)
Abstract
Intruduction: Testicular feminization syndrome is a disorder with the prevalence of 1 in 20000 to 64000 male births. It,s characteristics are female phenotype, male caryotype (64XY) and normal to increased testosterone and LH levels. In this article a case of testicular feminization is reported. Case: The patient was a 16 years-old woman with primary amenorrhea and without secondary sexual characteristics. The patient had normal female external genitalia, absent axillary and pubic hair, immature breast, and repaired bilateral inguinal hernia with pathology report of immature testicular tissue. FSH and LH levels were elevated. Testosteroe level was normal. Sonography and CT scan of pelvis did not show uterus and adnex. Karyotype was 46XY. Conclusion: It is recommended that due to the risk of neoplasia, the existing testes must be removed. Also hormone therapy must be done for the patient.
Ahmad Ameri, Jamshid Ansari, Majid Mokhtari, Ali Chehrei,
Volume 9, Issue 4 (12-2006)
Abstract
Introduction: Radiotherapy after breast cancer surgery will increase local control of the disease and also increase overall survival. Radiation have some side effects on lung function. In different radiotherapy techniques, these side effects are different. Pulmonary function tests and oxygen saturation are methods for evaluation of these complications. In this study we decide to campare pulmonary complications in two radiotherapy methods. Materials and Methods: In this clinical trial study fifty one patients with breast cancer in stage II and III according to TNM staging system, which were under modified radical mastectomy in Imam Hosein hospital and refered for adjuvant radiotherapy, randomly divided in two groups. In one group patients were treated with three field technique and in others with four field technique. All patients received total dose of 48-50 Gy. For patients, pulmonary function test and pulse oxymetery were done once before initiation of radiotherapy and then one and three months after radiotherapy. Results: Measurement of FEV1 , FVC and show that no significant statistical difference was present between the two groups one month and three months after radiotherapy, also in each of the two groups the amount of FEV1 , FVC and one month after radiotherapy had no significant statistical difference in comparison to baseline tests but FEV1 and FVC after three months was decreased and had significant statistical difference respectively (p<0.001, p<0.006). SO2 had no significant defference between the two groups and also in each group after one and three month of radiotherapy. Conclusion: Locoregional radiotherapy of breast and lymph nodes areas causes a decrease in some parameter of pulmonary function tests but no difference was present between three field and four field techniques.
Mohammad Reza Nikmaram,
Volume 10, Issue 4 (12-2007)
Abstract
Introduction: In resent years, neuronal type Na+ channel is one of the important currents for action potential depolarization phase in heart cells. In this study neuronal type Na+ channel is blocked by low concentration of Tetrodotoxin (TTX) to compare the effect of TTX blocker on pacemaker activity of sinoatrial node (SAN) and atrioventricular node (AVN) of mouse heart. Materials and Methods: In this experimental study the pacemaker activity of distinct intact SAN and AVN, was recorded before and during consuming 100 nM TTX, and cycle length (CL) was measured. Data was analyzed using t-test. Results: 100 nM TTX increased CL on SAN preparations by 22.2±6% and on AVN preparations by 52.5±13.5 %. These changes were significant in the two nodes. Conclusion: It is passible to conclude that the neuronal type Na+ channel was present in the two nodes, and the effect of TTX on CL of the two nodes was different.
Naser Sharafaddin-Zadeh, Reza Bavarsad Shahripoor,
Volume 10, Issue 4 (12-2007)
Abstract
Introduction: Sneddon syndrome is a combinaison of skin lesions (Livedo Reticularis) and acute cerebrovascular accident. The syndrome involves many organs such as kidney, heart, skin and brain. Some patients have a good prognosis when taking Aspirin and Diprydamol. In this article a case of this syndrome is reported. Case: The patient is a 40 years old woman with a history of 8 times intrauterine fetal deaths. She was admitted to the neurology ward with signs of weakness in left side of the body (hemiparesis), dysarthria, 7th central nerve paralysis, and skin lesions (Livedo Reticularis). All laboratory data such as serology and microbiology were normal. After skin biopsy from the lower limbs and rule out possible secondary etiologies, this patient was recognized with Sneddon syndrome and recieved antiplatelet treatment. Conclusion: Despite the fact that this syndrome is rare, it seems considering the probability of appearing this syndrome, especially in young patients who are suffering from acute cerebrovascular signs and skin lesions in the same time, early treatment can prevent the desease from developing to other organs.
Saeid Sadrnia, Ali Chehrei,
Volume 11, Issue 1 (3-2008)
Abstract
Introduction: Left ventriculor hypertrephy (LVH) is one of the complicotions of systemic hypertension. LVH increases probabiltis of cardiac arrhytmia and cardiovasculer event in hypertensive patiants. In addition to hypertension other factors such as dyslipidemia, hyperglicemia and renal failure can cause LVH. This study was designed to investigate the effects of Body Mass Index (BMI) and some laboratory factors on LVH. Materials and Methods: This is a case-control study in which patients in case group (hypertensive patients with LVH) and patients in control group (hypertensive patients without LVH) were compared for BMI, dyslipidemia, hyperglycemia, and elevated Blood Urea Nitrogen (BUN) and Creatinin. Data was analyzed using Chi square test and logistic regression. Results: BMI with, high blood glucose with, high BUN and Creatinin signiticant affect in LVH presentation in hypertensive patiants. Dyslipidemia had not signiticant affect. Conclusion: In this study BMI, hyperglicemia, high BUN and Creatinin affected LVH presention in hypertensive patiant. So it is recommended that these factors be carfuly monitored and and treated.
Vahid Sheibani, Mohammad Ali Afarinesh Khaki, Zahra Hajizadeh, Mandana Jafari, Razeieh Arabnezhad, Ali Shamsizadeh,
Volume 11, Issue 3 (9-2008)
Abstract
Background: Pain is an unpleasant feeling which humans experience. It is a warning sign of the damaged tissue. Due to the awful sense of pain, scientists always attempt to relieve it. Retinoic acid (RT), an active metabolite of natural vitamin A has important roles in modulation of the inflammatory responses. The aim of the present study was to analyze the pain threshold of rats which had microinjections of RT, applying acute and chronic models. Methods and Materials: In this study, the tail flick and formalin tests were used to determine pain threshold. In each test, the acute and chronic pain thresholds of 252 Wistar male rats (275 ± 25 gr) were assayed. The druge were injected in the acute model one-dose30 minutes before behavioral testing and in chronic model two-dose for one or two-weeks. The rats of both models divided randomly into six groups (n=7). In four treatment groups retinoic acid (RT) intra cerebro ventricular (i.C.V) were injected as dosagc of 0.5, 3 and 6 (µg/kg) micrograms per kilogram. In control group, was microinjected by ACSF. In vehicle group injected RT solvent (DMSO+ Distil water). Results: The resuits Showed acute injection of RT did not change pain thresholds in the tail-flick methd, but the chronic administration of RT (0.5, 1, 3, 6 µg/kg) reduced tail-flick latencies of the rats (p<0.05) in compare to DMSO group. The threshold of pain in the first phase of formalin test was reduced after injection of 3µg/kg of RT for two weeks. Conclusion: It was concluded that chronic i.c.v. injections of RT can induce significant hyperalgesia in rat.
Shirin Pazoki, Bizhan Yazdi, Ahmad Sarvarian, Raheleh Aliabady,
Volume 11, Issue 4 (12-2008)
Abstract
Background: Post operative nausea and vomiting (PONV) is a very common and distressing complication after surgeries which may result in more serious problems such as incisional hernia wound dehiscence and aspiration. Cataract surgery following increase in intraocular pressure is sensitive to POVN. This study was designed to evaluate the effect of capsicum ointment on Korean acupressure points in reducing PONV and the amont of anti- emetic medications was used. Methods and Materials: This study is a double-blinded clinical trial which was done on 200 patients who were referred to Amir Kabir hospital for cataract surgery. The patients were randomized assigned to two groups, one who received capsicum ointment and the other placebo (vaseline ointment) at the pressure points (K-K9 and K-KD2). After applying the ointments and during the first 12 hours after the operation the patients were assessed for the incidence and intensity of PONV. Results: The incidence of nausea and vomiting during the first 6 and 12 hours was higher in the placebo group in compare to the capsicum group (p=0.001). Nausea scores were also higher in the 6 and 12 hours in the placebo group (p=0.0005). Uses of metoclopramide was significant higher in the placebo group in compare to the capsicum group (p=0.001). There was no significant difference between the two groups for vomiting during first 12 hours ofter opration. Conclusion: Stimulating of both K-D2 & K-K9 Korean acupressure points simultaneously is a simple, noninvasive, cheap and effective method for reducing PONV.
Farshideh Didgar, Majid Akbari, Hossein Sarmadian, Masoomeh Soufian,
Volume 13, Issue 3 (9-2010)
Abstract
Background: Brucellosis, a zoonotic disease with worldwide spread, is a common disease in Iran and is endemic in Markazi Province. Brucella osteomyelitis, on the other hand, is a rare disease. Here we reported a case of brucella osteomyelitis of the tibia following trauma. Case: The patient was a 22 year old man referring with chronic draining tibia ulcer. He had a history of trauma of the tibia, dating back to 3 years ago, for which local prosthesis had been prescribed. Later on, the prosthesis had been removed due to infection. Staining of the tissue samples indicated the presence of gram-negative coccobacill and brucella growth in the culture of excretions. Conclusion: This case was reported because of rare presentation of brucella and the educational implications of the patient with respect to the possibility of brucella development in chronic ulcers or prosthesis. Although uncommon, brucellosis should be regarded as a potential cause of osteomyelitis in patients with a record of physical contact with animals.
Latif Moini, Ali Fani, Babak Peyroshabany, Mahmodreza Baghinia,
Volume 14, Issue 4 (9-2011)
Abstract
Background: APACHE IV scoring system is one of the most useful scoring systems for evaluating the quality of health care services in ICU. The aim of this study was to evaluate the quality of health care services in ICU wards of Valiasr and Amiralmomenin Hospitals of Arak. Materials and Methods: This cross-sectional study was conducted on 100 patients admitted to ICU wards in Valiasr and Amiralmomenin Hospitals of Arak. First, the predicted mortality and length of stay (LOS) in ICU were calculated by APACHE IV scoring system. Then the real mortality and the real length of stay in ICU were recorded. Data were analyzed by SPSS software version 11.5 and t-test. Results: Real mortality in men and women were 57.2% and 61.9%, respectively. The real length of stay in men and women were 11.58 and 11.62 days, respectively. Predicted mortality calculated by APACHE IV in men was 23.72% while it was 24.1% in women. Predicted LOS by APACHE IV in men was 15.02 days while it was 16.64 days in women. There was a significant difference between real mortality and predicted mortality (P = 0.001). Conclusion: The findings of this study indicate that the quality of health care services in ICU wards of Valiasr and Amiralmomenin Hospitals of Arak are far from international standards.
Parivash Kazemi, Habiballa Jowhary, Esfandiyar Sharifi, Akbar Zeraatpishe,
Volume 14, Issue 6 (1-2012)
Abstract
origanum vulgare l.spp viride was used in ancient medicine and it was medicated for digestive disease, diabetes, remedy of trauma. While antimicrobial, ant diabetic, anticancer and antioxidant effect of this plant was proved but there is done no study for its effect on reproductive system. Therefore the purpose of recent study is surveying eventual androgenic effect of this plant on hormonal level of pituitary - gonadal axis in mature male vistar rats.
Materials and Methods: recent study was done on five groups of male rats of vistar race and every group includes nine rats. The control group received no drug. The sham group received physiological serum and experimental groups of A, B and C were received the ethanolic extract of origanum vulgare l. with concentration of 40, 20, 10 mg/kg body weight respectively with gavaj for 14 days. Then levels of FSH, LH and TSH hormones in blood sample was measured with RIA method and obtaining result was compared between control group and other groups. Data was analyzed with SPSS software and statistical method of ANOVA and Tukey test. In this research, significant level was p<0.05.
Results: in control group, sham group and A, B and C groups, respectively mean and standard deviation from average of plasma concentration for LH hormone based on mlU /ml were: 0.18±0.006, 0.183±0.017, 0.187±0.026, 0.241±0.012 and 0.284±0.027 And for FSH Hormone were: 0.321±0.025, 0.342±0.071, 0.372±0.026, 0.383±0.031 and 0.372±0.026 And for TSH hormone were: 5.28±0.683, 6.07±0.5, 6.09±1.94, 6.66±1.48 and 8.1±1.66.
Conclusion: ethanolic extract of origanum vulgare leaf in maximum dose have androgenic effects and it can affect the activity of different levels of hypothalamic – pituitary – gonadal axis and increase the secretion of testosterone and gonadotropic hormones.
Valiollah Khadir Sharabiany, Saeed Oraii,
Volume 16, Issue 3 (6-2013)
Abstract
Background: Nowadays, many patients with cardiovascular diseases require pacemaker implantation that is associated with few complications such as cardiac and valvular insufficiency. This study aims to compare the development of tricuspid and mitral regurgitation in right ventricular outflow tract (RVOT) and right ventricular apex (RVA) pacing.
Materials and Methods: In this single-blind clinical trial, 164 candidates for permanent pacemaker (PPM) implantation due to sick sinus syndrome or atrioventricular block were randomly divided into 2 equal groups to receive either RVOT or RVA pacing. Patients with heart failure or valvular diseases were excluded from the study. Pre and post-procedural echocardiography after 6 months were performed and the results were compared for the development of mitral and tricuspid regurgitation and probable changes in the ejection fraction (EF).
Results: Age, gender, pacing mode, and baseline cardiac rhythm did not significantly differ between RVOT and RVA pacing groups. The incidence of mitral regurgitation was significantly higher in the RVA group (p=0.033), whereas the incidence of tricuspid regurgitation was similar in both groups (p>0.05). There was a trend toward less tricuspid regurgitation in the RVOT group however, it was not statistically significant. Ejection fraction was not significantly different between the study groups.
Conclusion: It seems that the incidence of mitral regurgitation in RVA pacing is significantly higher than RVOT although this needs further investigation in future studies.
Pariya Karampoor, Mahnaz Azarnia, Ghadireh Mirabolghasemi, Farzane Alizadeh,
Volume 17, Issue 5 (8-2014)
Abstract
Background: Fennel (Foeniculum vulgare) has estrogenic, anti-inflammatory and antioxidant effects and traditionally used for treatment of infertile women. Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder in women, which affects 5-10% of them in their reproductive age. This study has examined the effects of hydroalcoholic extract of Fennel on female Wistar rats with PCOS.
Materials and Methods: In this experimental study, 30 rats (200 ± 20 gr), was injected 2 ml of estradiol valerate subcutaneously and 6 rats were considered as control(intact). After 60 days, the rats were divided into control, sham and experimental groups. Rats in experimental group were treated with 250, 500, 1000(mg/kg BW) of intraperitoneal injections extract of Fennel for 10 days. Serum FSH, LH and Testosterone were measured by ELISA and serum levels of these hormones between treatments all groups were compared using One-Way ANOVA at a significance level of p<0.05.
Results: The data suggests that extract of Fennel can increase serum concentrations of FSH and decrease LH and Testosterone in treatment groups. As FSH is 500 and 1000 mg/kg levels of doses, LH and Testosterone in dose 1000 mg/kg have shown statistically significant differences compared to control groups.
Conclusion: Considering the increasing positive effect of extract of Fennel on serum concentration of FSH and decreaseing LH and Testosterone in rats with PCOS, this compound might be considered for treatment of the patients.
Leila Akhtar Danesh, Zeinab Saiedi Nejad, Hossein Sarmadian, Alireza Amouzandeh-Nobaveh, Aliasghar Farazi, Ehsanollah Ghaznavi-Rad,
Volume 18, Issue 8 (11-2015)
Abstract
Background: Staphylococcus aureus is one of the important pathogens can cause infections in hospitals specially in intensive care units (ICU). It seems that nasal carriage is important risk factor for developing l infection at ICU units. This study was designed to investigate the frequency of S. aureus nasal carriage and its virulence in patients admitted to ICU units in Vali-Asr hospital at Arak university of medical sciences.
Materials and Methods: In this cross-sectional study, nasal swab samples were obtained from all the patients hospitalized in ICU unit of Vali-Asr hospital from July-December 2014 at admission. After identification, methicillin resistance and the frequency of pvl and acme genes determined by PCR. Demographic data were collected using questionnaire and were analysed using SPSS 20 software.
Results: Out of 390 patients, 81(20.8%) and 31(12.9) patients had been colonized with MSSA and MRSA, respectively. The result of culture was negative for 278 patients (71.3%). 77.4% of MRSA and 54.3% of MSSA isolates were positive for acme gene. Also, 11.11% of and 6.45% of MSSA MRSA isolates were positive for pvl gene.
Conclusion: The application of medical supportive devices like cv line, ventilator, history of surgery operation and antibiotic use significantly was associated with S. aureus nasal carriage. High prevalence of S.aureus shows that these bacteria settled in the hospital. Hence, infection control measures must be performed to reduce the risk of hospital infection.
Abdoreza Yavari, Farhad Fatehi, Hamid Dalvand, Akram Valizadeh, Rahmatollah Moradzadeh, Farideh Sadat Mirhoseini,
Volume 19, Issue 6 (9-2016)
Abstract
Background: The speech disorders may produce irreparable damage to childs speech and language development in the psychosocial view. The voice, speech sound production and fluency disorders are speech disorders, that may result from delay or impairment in speech motor control mechanism, central neuron system disorders, improper language stimulation or voice abuse.
Materials and Methods: This study examined the prevalence of speech disorders in 1393 Arakian students at 1 to 6th grades of primary school. After collecting continuous speech samples, picture description, passage reading and phonetic test, we recorded the pathological signs of stuttering, articulation disorder and voice disorders in a special sheet.
Results: The prevalence of articulation, voice and stuttering disorders was 8%, 3.5% and%1 and the prevalence of speech disorders was 11.9%. The prevalence of speech disorders was decreasing with increasing of student’s grade. 12.2% of boy students and 11.7% of girl students of primary school in Arak had speech disorders.
Conclusion: The prevalence of speech disorders of primary school students in Arak is similar to the prevalence of speech disorders in Kermanshah, but the prevalence of speech disorders in this research is smaller than many similar researches in Iran. It seems that racial and cultural diversity has some effect on increasing the prevalence of speech disorders in Arak city.
Fateme Niazi , Maryam Tehranipour, Khadije Shahrokhabadi,
Volume 19, Issue 7 (10-2016)
Abstract
Background: Angiogenesis is an important biological processes of new blood vessels in many pathological stages of development and embryo development occurs and a complex and dynamic phenomenon that is needed for development and other physiological processes. This study aimed to investigate the effect of alcoholic Ocimum basilicum leaf extract on angiogenesis chick chorioallantoic membrane is done.
Materials and Methods: In this experimental study 40 Ross fertilized eggs were randomly divided into four groups: control, sham-exposed and experimental groups were divided. The second day of incubation the eggs window was opened. Eighth day of the alcoholic extract of basil doses of 50 and 150 mg/kg on chick chorioallantoic membrane was injected. On day 12, embryos length and weight and chorioallantoic membrane (CAM) was photographed by photostereomicroscope Then the numbers and lengths of vessels in special area on CAM were measured with Image J. analyzed through by t-test and ANOVA (P<0.05).
Results: The data does not show significant difference between embryos length and weight in sham compare to all experimental groups. In the study vessels number just with 150 mg/kg observed significant.
Conclusion: Alcoholic extract of basil is an increase in the number of vessels and in this sense the healing and growth processes associated with them as well as effective.
Esmaeil Fattahi, Vahid Hemayatkhah Jahromi ,
Volume 19, Issue 8 (11-2016)
Abstract
Abstract
Background: Eryngium caucasicum Trautv has antioxidant properties due to the presence of flavonoids and phenolic compounds. So, the present study was done to investigate the protective effects of Eryngium caucasicum Trautv extract on tricyclazole induced hepatotoxicity in mice.
Materials and Methods: In this experimental study, 42 mice were divided into 6 groups including control, sham, tricyclazole (TCZ) and three experimental groups. The mice in the tricyclazole group, received 50 mg/kg TCZ via intraperitoneal injection and experimental groups 2, 3 and 4 received respectively 100,200and 400 mg/kg of extract via gavage for 4 weeks and 2 days per week. The sham group received only sterile water. At the end, serum levels of ALT, AST and ALP, serum concentration of albumin and total bilirubin were measured. Also, total phenolic compounds and flavonoids in the extract were measured. Data were analyzed by using ANOVA.
Results: Tricyclazole increased serum levels of aminotransferase, phosphatase alkaline and total bilirubin and decreased serum concentration of albumin. But, treatment with extract decreased liver enzymes and bilirubin and increased levels of albumin (p<0.05). Amount of total phenolic compounds and the flavonoids were measured 91.16 mg/gr galicacid in extract and 84.48 mg/gr quercetin in extract, respectively.
Conclusion: The results demonstrated that Eryngium caucasicum Trautv extract due to the presence of high phenolic compounds has protective effects on tricyclazole induced hepatotoxicity.
Ali Arjmand Shabestary, Mahmoud Khaloei, Mohammad Arjomandzadegan, Zahra Eslamirad, Reza Ghasemikhah,
Volume 20, Issue 8 (11-2017)
Abstract
Abstract
Background: Resistance of Acanthamoeba cysts causes recurrence of the disease; so, the patient should be monitored regularly ،The aim of the study was to examine the effect of a few herbal materials on Acanthamoeba cysts in vitro.
Materials and Methods: Essential oils (EOs) of Zataria, Mint, and Oregano were prepared by steam distillation. The EOs and Hypericum perforatum extract were prepared in three concentrations (0.6%, 1% and 10%)، Acanthamoeba cysts in various time intervals (30, 60, 120, 180 and 1440 minutes) were exposed with plant extracts. Then, the viability of parasite was investigated by eosin 0.1%.
Results: Comparison of the parasite mortality rate between control and case groups showed that the mortality of Acanthamoeba cysts was higher in the case groups that exposed to herbal materials. At the equal concentration (10%) and time (24 h), the Zataria and mint EOs produced the highest (22%) and lowest (4%) mortality, respectively. The results showed the mortality rate of Acanthamoeba was time-dependent.
Conclusion: Zataria showed the most fatality effect against Acanthamoeba cysts. In this respect, clinical trial studies are suggested.
Fatholah Mohaghegh , Mehran Mohseni, Nasrin Robatmili, Mohamad Reza Bayatiani , Fatemeh Seif, Nayyer Sadat Mostafavi,
Volume 21, Issue 6 (12-2018)
Abstract
Background and Aim: Radiation therapy is the destruction of cancer cells that in all patients with breast cancer reduces tumor recurrence, relieves pain in local tumors and metastases. There are different treatment methods around the world such as electron, photon alone or a combination of both types of fields.
Materials and Methods: In this study, photon therapy (PT) and mixed photon-electron therapy (MPET) were used to treat malignancies of the supraclavicular lymph nodes. 30 patients with right-sided breast cancer with local lymph node metastasis were recruited. The ISOgray software was utilized to collect data about treatment planning methods with PT and MPET.
Findings: The maximum and mean delivered doses of radiation to the supraclavicular region were 52.08±1.64, 42.59±0.51 Gy and 54.24±1.64, 43.67±0.43 Gy in the PT and MPET methods, respectively. The mean irradiated volumes of supraclavicular fossa that received 90% of the radiation dose were 59.74±1.94% and 70.26±0.94% in the PT and MPET methods, respectively (p=0.004). The maximum doses delivered to the spine were 14.66±1.9 Gy and 10.22±0.92 Gy and the thyroid were 42.62±3.1 Gy and 37.67±5.02 Gy in the PT and MPET methods, respectively.
Conclusion: The maximum doses delivered to the spine and thyroid significantly diminished by the novel method. Additionally, supraclavicular region received higher maximum and mean doses in the new treatment modality compared to the conventional methods. The new method improved dose coverage for the tumor.
Mohammad Amin Edalatmanesh, Habibollah Khodabandeh, Nooshin Yazdani, Samaneh Rafiei,
Volume 21, Issue 6 (12-2018)
Abstract
Background and Aim: Neuropathy is the most common abnormality in diabetes mellitus which characterized with cerebral damages especially in hippocampus. This study evaluates the effect of Cinnamomum Zeylanicum extract (CZE) on memory, hippocampal neuron damage and antioxidant enzymes levels in animal model of diabetes.
Materials and Methods: 50 adult Sprague dawley rats were randomly divided into 5 groups: Control, STZ (Streptozotocin, 50 mg/kg; i.p.), and STZ + CZE100, STZ + CZE200 and STZ + CZE400 which were treated with CZE in 100, 200 and 400 mg/kg, respectively. CZE was administered in 14 days, orally. After evaluation of working and spatial memory, activity of catalase (CAT) and glutathione peroxidase (GPx) enzymes was assessed by ELISA. Then, histopathological assessment of hippocampus was done.
Findings: In comparison with the controls, STZ group showed an increase in latency time and distance to the hidden platform in MWM, a decrease in alteration behaviors, cell density and activity of CAT and GPx enzymes in hippocampus (p˂0.05). In addition, treatment with CZE decreased latency time and distance in MWM and increased alteration behavior, hippocampal cell density and activity of antioxidant enzymes in comparison with the STZ group (p˂0.05).
Conclusion: Diabetes with reduction of neuronal density and activity of antioxidant enzymes in the hippocampus causes deficits in spatial and working memory. However, Administration of CZE ameliorates these neuropathologic disorders.
Farzaneh Jajarmi, Ahmad Jonidi Jafari, Majid Kermani, Mitra Gholami,
Volume 22, Issue 1 (4-2019)
Abstract
Background and Aim: Dust was considered by researchers as one of the most important forms of air pollution. The aim of this study was to identify the physical and chemical characteristics of dust storm sources in Tehran.
Materials and methods: This study was conducted in selected air sampling stations of Tehran, in the days of dust and ordinary from January 2016 for one year. The concentration of dust particles was determined by gravimetric. Heavy metal concentrations in samples after digestion were determined with graphite furnace atomic absorption spectrometry (AAS-GF). Mineralogy and morphology of the dust fall particles were inspected using X-ray diffraction and scanning electron microscopy and sources particles using Enrichment Factor Analysis and principal component analysis (PCA) were performed. For statistical analysis, R software was used.
Ethical Considerations: This study with research ethics code IR.IUMS.REC.1397.313 has been approved by research ethics committee at Iran University of Medical Sciences.
Findngs: The highest average particle concentration in normal days was related to the central station (122.63 µg / m3), and the lowest for the East Station (67.13 µg / m3). The highest concentrations of the elements measured in the particles are related to iron and aluminum and the lowest concentrations of chromium and nickel. Lowest amount of Enrichment Factor was obtained for iron, less than one.
Conclusion: The results of this study indicated that the concentration of dust in center was higher than other station. Natural and human resources both play a significant role in the release of metals. By conducting further studies on the source of dust in Tehran and using the results, effective control measures can be designed and implemented.
