Showing 8 results for Hypertrophy
Saeid Sadrnia, Ali Chehrei,
Volume 11, Issue 1 (3-2008)
Abstract
Introduction: Left ventriculor hypertrephy (LVH) is one of the complicotions of systemic hypertension. LVH increases probabiltis of cardiac arrhytmia and cardiovasculer event in hypertensive patiants. In addition to hypertension other factors such as dyslipidemia, hyperglicemia and renal failure can cause LVH. This study was designed to investigate the effects of Body Mass Index (BMI) and some laboratory factors on LVH. Materials and Methods: This is a case-control study in which patients in case group (hypertensive patients with LVH) and patients in control group (hypertensive patients without LVH) were compared for BMI, dyslipidemia, hyperglycemia, and elevated Blood Urea Nitrogen (BUN) and Creatinin. Data was analyzed using Chi square test and logistic regression. Results: BMI with, high blood glucose with, high BUN and Creatinin signiticant affect in LVH presentation in hypertensive patiants. Dyslipidemia had not signiticant affect. Conclusion: In this study BMI, hyperglicemia, high BUN and Creatinin affected LVH presention in hypertensive patiant. So it is recommended that these factors be carfuly monitored and and treated.
Fazad Zamani, Parsa Yousefi, Mohammad Rafeei, Neda Saleh Jafari,
Volume 16, Issue 7 (10-2013)
Abstract
Background: Adenoidal hypertrophy is a common condition of childhood, when abstructive sleep apnea ocurs adenoidectomy is indicated. In less sever cases, non surgical interventions maybe considered, however few medical altematives are currently available. Intranasal steroids used to reduce nasal airway obstruction. The aim of this study to assesthe effectiveness of intranasal corticosteroids for improving nasal airway obstruction and in children with adenoid hypertrophy.
Materials and methods: 77 children 1-12 years exhibiting adenoid hypertrophy symptom and confirmed with radiologic imaging and without tonsilar hypertropy that not inclined to surgery were included and divided two groups in one group were treatend with intranasal betanethason 3 times daily for 3 weeks and and second group treatend with intranasal NACL as placebo. The subjects were assessed for airway obstruction symptoms including, snoring mounth breathing and prulaunt rhinorea, via questionarre ear examination, first month and third month of treatment.
Results: Intranasal betanethasone improved airway obstruction symptoms especially night snoring but hadn’t effective on other symptoms and infection complications including rhinorea.
Conclusion: Intranasal betanethasone can be used as alterative treatment for adenoidal hypertroply because its effect on airway obstruction symptoms due to probably reduction adenoideal size.
Mohabbat Jamhiri, Zeinab Hafizibarjin, Mojtaba Ghobadi, Ali Moradi, Fatemeh Safari,
Volume 20, Issue 4 (7-2017)
Abstract
Abstract
Background: Oxidative stress plays an important role in the pathogenesis of hypertension- induced cardiac hypertrophy. Plants are a rich source of antioxidant compounds. Thymol is a natural monoterpen phenol which is plentiful in some plants and shows many biological effects. The aim of the present study was to assess the effects of thymol on activity of antioxidant enzyme catalase, malondialdehyde (MDA) level and the activity of the inhibition of free radical DPPH (2,2-Diphenyl-1-picryl-hydrazyl), following left ventricular hypertrophy in rats.
Materials and Methods: In this experimental study, rats were divided into hypertrophied group without any treatment (H group) and rats pretreated with 25 and 50 mg/kg/day of thymol (Thy25+H and Thy50+H groups, respectively). Intact animals were served as control (Ctl). Animal model of left ventricular hypertrophy was induced by abdominal aortic banding. Serum catalase (CAT) activity, malondialdehyde (MDA) level and the activity of inhibition of free radicals DPPH were determined by the biochemical methods.
Results: In Thy25+H and Thy50+H groups, the CAT activity was increased significantly in serum (p<0.01, vs. Ctl). Also, serum level of MDA was decreased significantly compared to the group H in Thy25+H and Thy50+H groups (p<0.05 and p<0.001, respectively). The effect of inhibiting DPPH free radicals was increased significantly in Thy25+H and Thy50+H groups compared to the group H (p<0.001 and p<0.05, respectively).
Conclusion: The findings of this study suggest that thymol as an antioxidant causes cardioprotective effects and as well as prevents left ventricular hypertrophy via augmentation of serum antioxidant capacity.
Moein Rahimi Sadegh, Amir Rashidlamir, Ali Akbar Haddad Mashhad Rizeh, Mohammad Soukhtanloo,
Volume 20, Issue 12 (3-2018)
Abstract
Abstract
Background: Recent Research has pointed to the involvement of lysyl oxidase (LOX) in the muscle development. Despite the fact, there is currently no direct evidence that lox is involved in the myogenic factors and exercise-induced hypertrophy. Therefore, the purpose of this study was to investigate the effect of lysyl oxidase inhibition on exercise-induced hypertrophy, as well as the gene expression of MyoD1, myogenin, TGF-β and LOX in FHL muscle of wistar rats.
Material and Methods: In this experimental research, 32 male Wister rats with an average weight of 220±15 were divided into four groups: resistance training, normal control, treated control and treated resistance training. Rats performed a resistance training for 8 weeks in which animals climbed a vertical ladder of 1m and inclined at 85° with weights attached to their tails. In order to inhibit lysyl oxidase, treatment group rats received daily injection of intraperitoneal β-aminopropionitrile (120 mg/kg/day). FHL muscle was extracted to measure relative muscle weight, as well as genes expression of MyoD1, myogenin, TGF-β and LOX by real time-PCR.
Results: Relative weight of FHL muscle was decreased significantly in the treated groups with BAPN, compared with normal groups (p<0.05). Lysyl oxidase showed a significant increase compared to the normal control group following a resistance training (p<0.05). LOX gene expression in treatment groups showed a significant increase compared to normal control group (p<0.05). TGF-β gene expression in BAPN-treated groups significantly was increased (p<0.05) and Myogenin in treatment groups showed a significant decrease compared to normal control groups (p<0.05). The expression of MyoD1 gene in treatment groups was only decreased significantly in the treated control groups compared to normal control groups (p<0.05).
Conclusion: Results showed that inhibiting the lysine oxidase enzyme could affect the genes involved in hypertrophy and reduce the hypertrophy induced by resistance training.
Soheil Biglari, Abbas Ali Gaeini, Mohammad Reza Kordi, Alireza Ghardashi Afousi,
Volume 21, Issue 1 (4-2018)
Abstract
Abstract
Background: The purpose of the present study is to investigate the effect of 8 weeks High-intensity Interval Training (HIIT) on the expression of two muscle growth regulating genes (myostatin and follistatin) in gastrocnemius muscle of healthy male rats.
Materials and Methods: 16 male Wistar rats were randomly divided into two groups in the same number: control and HIIT. HIIT program was underwent 40 min each session, three sessions in a week for eight weeks. Each exercise training session consisted of 5 min warm-up and cool-down at 40-50 % VO2max, 30 min interval running including 4 min high-intensity (85-90% VO2max) and 2 min active recovery (at 50-60% VO2max). Rats in control group did not do any exercise training program. 48 h after the last training session, rats` gastrocnemius muscle was extracted and the expression of myostatin and follistatin genes was determined by Real Time-PCR. For statistical data analysis, independent t-test was used.
Results: The expression of myostatin was significantly reduced 68% in HIIT group in comparison with the control group (p<0.05). However, there was no significant difference in follistatin expression in HIIT group compared to the control group (p>0.05). Gastrocnemius muscle weight was significantly increased 23% in the HIIT group compared to the control group (p<0.05).
Conclusion: Results indicated that HIIT lead to significant reduction in the expression of myostatin gene and increase in the weight of gastrocnemius muscle in rats.
Farzad Zamani,
Volume 22, Issue 4 (9-2019)
Abstract
Background and Aim Inferior turbinate hypertrophy is one of the most common causes of nasal obstruction after nasal septal deviation. Enlargement of the turbinate is the result of the position of turbinate bone or swelling of turbinate submucosal. This study aimed to evaluate the effectiveness of the SubMucosal Resection (SMR) method with electrocautery method in the treatment of inferior turbinate hypertrophy.
Methods and Materials A total of 140 patients with inferior turbinate hypertrophy complicated with nasal congestion and rhinorrhea and candidate of surgery were randomly divided into two groups. In the first group, after induction of anesthesia, we performed SMR of inferior turbinate hypertrophy. In the second group, after induction of anesthesia, we performed monopolar cauterization with 20-gauge angiocath in three anterior, middle, and posterior regions and crests of the inferior turbinate.
Ethical Considerations This study was approved by the Ethics Committee of Arak University of Medical Sciences (Code: 91.133.3).
Results In the electrocautery group, a significant improvement was observed in nasal congestion after 6 months (P=0.017). In the SMR group, a satisfactory headache improvement was reported (P=0.034), one month after the operation. Also, the electrocautery group reported less pain and burning in the site of surgery, sneezing, coughing, and itching (P=0.013).
Conclusion Electrocautery can be superior over SMR because of its less bleeding, shorter time of surgery, the availability of primary equipment, and relative improvement in decreasing the rhinorrhea. However, if the patient suffers from isolated inferior turbinate hypertrophy, SMR as a suitable method is recommended.
Zahra Yousefvand, Masoud Rahmati, Rahim Mirnasuri,
Volume 27, Issue 3 (7-2024)
Abstract
Introduction: Considering the synthesis and release of myokines from muscle tissue during exercise and the relationship of myokines with the development of strength and increase in muscle volume, the purpose of this study is to investigate 12 weeks of resistance training on the serum levels of myonectin and FGF- There were 21 middle-aged men.
Methods: In a semi-experimental study, 40 middle-aged men of Arak city (mean age 38.27 ± 6.02 years, weight 77.12 ± 11.23 kg, height 174.05 ± 7.22 cm) were selected and randomly placed in two resistance training groups (20 people) and control (20 people). The training group performed 12 weeks of resistance training 3 times a week with an intensity of 65-80% of maximum strength. Blood was taken from all the subjects 48 hours before and after the intervention, and serum levels of myonectin and FGF-21 were checked by the ELISA method. After checking the normality of the data, they were analyzed by the correlation t-test and independent t-test at a significance level of less than 0.05.
Results: Resistance training caused a significant increase in the serum level of myonectin (P = 0.001) and the serum level of FGF-21 (P = 0.001) and also decreased the percentage of fat (P = 0.417) in middle-aged men.
Conclusions: According to the results of this study, it seems that resistance training can have positive adaptation by increasing the serum levels of myonectin and FGF-21 in the regulation of muscle mass, hypertrophy process, angiogenesis process, and Improve the body's metabolism.
Mohammad Ali Gharaat,
Volume 27, Issue 4 (10-2024)
Abstract
Introduction: Physical activity causes cardiac hypertrophy by a non-pathological change in cardiac structure, called physiological hypertrophy. Several molecular changes are involved in this process. Insulin-like growth hormone-1 (IGF-1) is an important hormone involved in hypertrophy of cardiomyocytes. Also, the role of GATA4 as a possible gene involved in cardiac hypertrophy is controversial. Therefore, the present study was conducted to find the effect of aerobic and interval training on IGF-1, GATA4 gene, and cardiac tissue.
Methods: Eighteen male Wistar rats (243.72 ± 23.41 g) were randomly divided into control, aerobic, and interval training groups (n = 6). The aerobic group trained for 8 weeks/4 days a week/38 minutes/ 65% of maximum oxygen consumption (VO2 max). The intermittent group trained 8 weeks/4 days a week/5 set/4 minutes/85-90% of VO2 max running with 2 minutes rest between the sets. The weight of the heart and left ventricle, IGF-1 concentration, and GATA4 gene expression were measured 48 hours after the training. The evaluation was conducted with a one-way analysis of variance and Tukey's post hoc test at a significance level of 0.05.
Results: The weight of the heart and left ventricle increased significantly in trained groups. IGF-1 and GATA4 gene expression increased in both the training groups than the control group.
Conclusions: Aerobic and Interval training increases IGF-1, GATA4 gene, left ventricle, and heart weight. Considering the shorter time interval training takes, it seems that interval training is more beneficial than aerobic training.
