Reza Rezaei, Mahnoosh Najafi, Amir Almasi-Hashiani,
Volume 15, Issue 6 (11-2012)
Abstract
Background: Age-related macular degeneration is the most common cause of irreversible central visual loss in individuals over 50 years old. The aim of this study was to assess visual loss due to age-related macular degeneration and some of its associated risk factors. Materials and Methods: This case-control study was conducted on 150 patients with age-related macular degeneration and 150 controls, both aged over 50. A questionnaire on demographic and medical information was completed for each participant and an ophthalmological examination was performed. The results were recorded andthe data were analyzed using SPSS software version 16. Results: Mean age of the subjects in the case and control groups was 78.38 and 79.28 years, respectively.In a multivariable model, hypertension(p=0.003), diabetes(p=0.006), light iris color(p=0.05), hypercholesterolemia (p=0.036), lens opacity (p=0.029), and previous cataract surgery(p=0.029) were significantly associated with age-related macular degeneration. There was not a significant relationship between body mass index (p=0.11) and refractory errors (p=0.94) andage-related macular degeneration. Conclusion: Age-related macular degeneration is associated with hypertension, diabetes, hypercholesterolemia, light iris color, lens opacity, and previous cataract surgery.
Farah Farokhi, Samira Riazi,
Volume 20, Issue 10 (1-2018)
Abstract
Abstract
Background: For treating hypercholesterolemic in traditional medicine, Anethum graveolens seeds are used that reduce blood glucose, cholesterol and triglyceride. The aim of this study is to investigate the effect of hydroalcoholic extract of Anethum graveolens seed on the changes of testis tissue, sperm parameters in hypercholesterolemic male rats.
Materials and Methods: In this study, 30 adult male rats were randomly divided into 5 groups of 6: control, hypercholesterolemic, hypercholesterolemic +alcoholic extract of Anethum graveolens seed 500 mg/kg/day, hypercholesterolemic +alcoholic extract of Anethum graveolens seed 300 mg/kg/day, healthy+alcoholic extract of Anethum graveolens seed 500 mg/kg/day. After treatment for 45 days, rats were weighed and after the dissection, sperm samples were collected from the tail epididymal and sperm parameters were studied. The testicular specimens were transferred to formalin and stained with hematoxylin-eosin. Data were analyzed using one-way ANOVA and Turkey's post- hoc tests and significant level (p<0.05) was considered.
Results: In this research, in the hypercholesterolemic rats, the testicular weight was increased, but the diameter of the semnifer tubes, tubal differentiation and spermiogenese, and sperm viability were decreased compared to control (p<0.05), but in hypercholesterolemic treatment with Anethum graveolens seed these parameters were improved.
Conclusion: According to the results of this study, Anethum graveolens seed has positive effects on testicular tissue and sperm parameters in hypercholesterolemic mice.
Ali Parvin, Parichehreh Yaghmaei, Mahdi Noureddini, Sayyed Ali Haeri Roohani, Saeed Aminzadeh,
Volume 22, Issue 1 (4-2019)
Abstract
Background and Aim: Hypercholesterolemia is an independent risk factor for atherosclerosis that the use of medicinal plants with minimal side effects is very important in the treatment of it. In this study, comparative evaluation of the effect of hydroalcoholic extract and quercetin of Otostegia persica Boiss with atorvastatin on ABC A1 gene expression in hypercholesterolemic male Wistar rats was carried out.
Materials and Methods: Forty male wistar rats with about 180gr weight randomly individed into five groups of eight: 3 experimental groups, 1 sham group and 1 control group. The experimental and sham groups received a high-fat diet with 2% cholesterol (through gavage) for 40 days. The experimental groups were treated (were fed) separately with 40 mg/kg/day atorvastatin, 25 mg/kg/day quercetin and 25 mg/kg/day hydroalcoholic extract of Otostegia persica Boiss for 28 days. Sham group received daily 1 mg/kg saline water during this period. In the end, the expression of ABC A1 gene was determined by Real-Time PCR in leukocytes and serum lipids were measured by photometric method.
Ethical Considerations: This study with research ethics code B/29/5/1/1799 has been approved by committee for ethics in biomedical research at Kashan university of medical sciensec on July 31, 2016.
Findings: The hydroalcoholic extract and quercetin of Otostegia persica Boiss and atorvastatin significantly increased ABC A1 gene expression in three experimental groups {(1.14 ± 0.09) ,(1.18 ± 0.03),(1.11 ± 0.03) respectively} realated to control group(1.00 ± 0.011) (p<0.05) and sham group(0.89 ± 0.03) (p<0.05). Quercetin also was more effective than atorvastatin in increasing of ABC A1 gene expression (p<0.05).
Conclusion: Quercetin and hydroalcoholic extract of Otostegia persica Boiss have increased effect on ABC A1 gene expression in hypercholesterolemic male Wistar rats.
