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Effect of Gentamycin Solution (80 mg) in Combination With Allograft Bone Material in Rat Bone Defect Regeneration
Maryam Jafarpour, Mojtaba Bayani, Leila Hesami-Moghadam, Ali Pooladi,
Volume 25, Issue 1 (3-2022)
Abstract
Background and Aim The use of allograft alone or in combination with other bone materials has significantly improved bone-augmentation procedures. Therefore, this study aimed to evaluate the effect of topical gentamicin solution (80 mg) with allograft on guided bone regeneration in defects in rat skull. 
Methods & Materials Twelve Wistar mice were randomly divided into two groups, with 6 in each group. Three defects were created in their skulls, one filled with demineralized freeze-dried bone (DFDBA) allograft alone, the other with allograft with gentamicin 80 mg solution, and the third defect were left empty as a control group. After 4 and 10 weeks, the mice were killed for histological specimens. Histological and histomorphometric evaluations were performed to qualitatively and quantitatively assess bone formation, a new bone type made, new bone vitality, inflammatory response, connective tissue type, and angiogenesis.
Ethical Considerations This study was approved by the ethics committee of Arak University of Medical Sciences (Code: IR.REC.ARAKMU.1397.30).
Results At the end of 4 and 10 weeks after surgery, the average percentage of ossification in the area of ​​defects was higher in the group that received allografts with gentamicin, and during this period, a significant difference was seen between these groups and the control group.
Conclusion According to the present study, the use of gentamicin in combination with DFDBA has a significant effect on bone regeneration in defects in the rat skull. 

An Investigation into the Histological Impacts of Thiamine on Renal Architecture in the Presence of Copper Oxide Nanoparticles
Rahmatallah Fatahian, Behnaz Karimi, Seyed Reza Hosseini, Kianoush Forouhar Majd, Ayatallah Hatempour ,
Volume 28, Issue 3 (8-2025)
Abstract
Introduction: The study discusses the impact of thiamine on the kidney tissue of rats that have been exposed to copper oxide nanoparticles. The research examined how thiamine correlates with the level of kidney damage caused by the intrusion of nanoparticles.
Methods: In this experimental study, forty male Wistar rats were randomly divided into four groups (10 rats per group). Two groups of rats were used as the control group (I) and the thiamine group (II). Rats of group III were administered an intraperitoneal injection of 25 mg/kg body weight of copper oxide nanoparticles for 14 days. Rats in group IV received the same dose of copper oxide nanoparticles along with thiamine (30 mg/kg body weight).
Results: The histopathological findings showed disruption of the arrangement of convoluted tubules and their disintegration and widening of the tubular lumen, cell separation and tubular necrosis in the majority of the renal tubules in-group III. In the group treated with copper oxide nanoparticles along with thiamine (IV), the pathological changes were slight and the majority of the tubules had retained normal structure. Statistically significant differences in the levels of some serum biochemical parameters (catalase, superoxide dismutase, TBARS, and TAC) were observed in groups III and IV on day 14 when compared to the control group.
Conclusions: This study demonstrated that thiamine can be utilized as an effective compound to reduce the damage caused by nanoparticles to kidney tissue and may lead to significant improvement in the health of kidney tissue in individuals suffering from damage caused by these nanoparticles.
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