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Background: Central giant cell granuloma (CGCG), also known as giant cell reparative granuloma, is a non-neoplastic proliferative lesion with unknown etiology which commonly occurs in the right side of the mandible. This lesion presents a wide variety of radiological and clinical manifestations that may lead to misdiagnosis. In many situations, CGCG is diagnosed through histopathological examinations. Case: In this study, a case of CGCG with irregular clinical and radiological aspect arising from the anterior, left side of the maxilla was reported. Conclusion: In differential diagnosis of swellings arising from the anterior portion of the maxilla, the possibility of CGCG should be considered. Also, histopathological examinations are of great importance in the diagnosis of CGCG.

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Background: Mycobacterium marinum is an atypical mycobacterium that causes a type of skin infection known as fish tank granuloma affecting people who are exposed to aquatic environments and manifests with erythematous, papulonodular or plaque-like lesions of the extremities. Case: A 15 year-old woman working in a tropical aquarium in Khomein referred with a non-tender nodule on the dorsum of fourth finger of left hand for 4 months. There were no specific findings in physical examination. Routine laboratory tests were normal. Skin biopsy was obtained which revealed suppurative granulomas, but staining of PAS and Ziel-Nelson were negative. The patient was treated with doxycycline 100 mg P.O. BID for 2 months with complete improvement of the lesions. Conclusion: In patients with a history of work in aquatic environments who manifest erythematous, papulonodular, or plaque-like lesions of the extremities should be checked in terms of fish tank granuloma and infection with mycobacterium marinum and skin biopsy and culture should be done for lesions.