Background: Glaucoma is the second most common cause of blindness and it is one of the main causes of irreversible blindness. Multi-drug regimens usually recommended in reducing intraocular pressure (IOP) in patients with glaucoma. This study was aimed to compare the effect of combination therapy with Timolol and Latanoprost vs. Timolol and Dorzolamide in reducing IOP in patients with open-angle glaucoma.

Materials and Methods: In this blind randomized clinical trial study, 60 eyes with glaucoma were randomly assigned to two treatment groups including Timolol and Latanoprost vs. Timolol and Dorzolamide. Required variables were measured before and 6 weeks after the intervention. The data was analyzed by running the Stata software (version 12) at a significance level of 0.05.

Results: The mean age in groups of Timolol-Latanoprost and Timolol and Dorzolamide was 72.6 and 67.6 years old, respectively. Analysis of the data revealed that there was no significant difference between groups in terms of intraocular pressure (IOP), visual acuity and cup to disc ratio.

Conclusion: According to our findings, there were no statistical significant differences in the IOP lowering effect between both treatments in open angle glaucoma patients.

Background: Oxidative stress and antioxidant status may be associated with glaucomatous damage. The purpose of this study was to compare the serum antioxidant status between primary angle closure glaucoma patients and healthy subjects.

Materials and Methods: In this case-control study 66 primary angle closure glaucoma patients and 80 controls were enrolled. Peripheral blood sample obtained from patients. Superoxide dismutase(SOD) was assayed by inhibition the rate of adrenochrome formation. Catalase (CAT) was evaluated by decrease of H2O2 absorbance. Glutathione peroxidase (GPx) and Glutathione reductase (GR) were determined following NADP oxidation or reduction. Glutathione S-transferase (GST) was measured by increase in the absorbance of CDNB and glutathione conjugation.

Results: Antioxidant defense enzymes were significantly decreased in glaucoma patients over those of control groups. CAT (p<0.006), SOD (p<0.020) and GPX (p<0.004). A relative insignificant decrease of GR and GST activities was observed in glaucoma patients compared with healthy subjects.

Conclusion: The present study supports the hypothesis that oxidative stress is an important factor in the pathogenesis of glaucoma. Although primary angle closure glaucoma has an anathomical basis but decrease in antioxidant defense enzymes activities may have a role in pathogenesis of this type of glaucoma.

  Background: Trabeculectomy is one of the most common ophthalmic surgeries, but over filtration may cause serious ophthalmic complications. The aim of this study is to compare two suture methods in trabeculectomy.

  Materials and Methods: This clinical trial accomplished on 28 eyes of 28 patients with primary open angle glaucoma unresponsive to full medication. Patients were divided into two equal groups. In one group, standard and the other group releasable suture trabeculectomy was performed. Post-Surgery short-term complications and intraocular pressure were compared in both groups.

  Results: The mean IOP reduction in group with releasable sutures was 22.14±13.99 and in standard group was 28.14±14.10 (p=0.269). Frequency of iridocorneal touch in releasable and standard groups was 7.1 and 50 percent, respectively(p=0.016). Also, Frequency of shallow anterior chamber in releasable and standard groups was 21.4 and 92.2 percent, respectively(p<0.001).

Conclusion: Trabeculectomy with releasable suture reduces short-term complications and in this group, IOP control is equal to standard trabeculectomy.