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Dermatoglyphic patterns are formed during the first and the second fetal development trimesters and they remain unchanged afterwards. At the end of the fourth month of fetal development, fingertips are formed along with brain and other derived ectodermia developments. In the 19th century, the mystery of human fingertips was discovered, and it was realized that fingertips consist of tiny network lines in the epiderms of the skin, and are exclusive to every individual, even to twins. In this study, through library research, by reviewing quantitative and qualitative dermatoglyphic patterns, the miracle of fingertips was considered based on Quran and Islamic commandments. Much research has been done comparing individual dermatoglyphic patterns of hands among various races, and the quantitative and qualitative relationship between dermatoglyphic patterns and diseases such as schizophrenia, nervous disorders, Down syndrome, diabetes I, Alzheimer, multiple sclerosis, congenital spinal abnormalities, and psoriasis disease has been shown. Accordingly, finger prints are used for identifying individuals, detecting criminals, and studying disease of genetic background. They can also be used as clues in determining the etiology of diseases. Fingertip sign is unique for every individual. Quran, in response to those who deny the resurrection after decomposition of the body and bones (Saffat, 37: 16), declares that Allah almighty, is not only capable of recreating them, but also is able to make human fingertips again (75: 3-4). The study shows the importance of human’s fingertips as the miracle of human creation, and reveals why Quran emphasizes on them as one indication of resurrection.